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This is a thought piece on data-intensive science requirements for databases and science centers. It argues that peta-scale datasets will be housed by science centers that provide substantial storage and processing for scientists who access…

Databases · Computer Science 2007-05-23 Jim Gray , David T. Liu , Maria Nieto-Santisteban , Alexander S. Szalay , David DeWitt , Gerd Heber

The histological assessment of human tissue has emerged as the key challenge for detection and treatment of cancer. A plethora of different data sources ranging from tissue microarray data to gene expression, proteomics or metabolomics data…

Computer Vision and Pattern Recognition · Computer Science 2016-01-05 Thomas J. Fuchs , Joachim M. Buhmann

Bioinformatics is a new discipline that addresses the need to manage and interpret the data that in the past decade was massively generated by genomic research. This discipline represents the convergence of genomics, biotechnology and…

Computational Engineering, Finance, and Science · Computer Science 2009-11-24 Sabu M. Thampi

This paper presents the overview of the current trends of Big data against the computing scenario from different aspects. Some of the important aspect includes the Exascale, the computing power and the kind of applications which offer the…

Distributed, Parallel, and Cluster Computing · Computer Science 2020-05-15 Sabuzima Nayak , Ripon Patgiri , Thoudam Doren Singh

Many key problems in machine learning and data science are routinely modeled as optimization problems and solved via optimization algorithms. With the increase of the volume of data and the size and complexity of the statistical models used…

Optimization and Control · Mathematics 2020-08-28 Filip Hanzely

Big data refers to large and complex data sets that, under existing approaches, exceed the capacity and capability of current compute platforms, systems software, analytical tools and human understanding. Numerous lessons on the scalability…

The exponential growth of data in current times and the demand to gain information and knowledge from the data present new challenges for database researchers. Known database systems and algorithms are no longer capable of effectively…

Databases · Computer Science 2017-12-06 Yaron Gonen

In this paper, we present BIMS (Biomedical Information Management System). BIMS is a software architecture designed to provide a flexible computational framework to manage the information needs of a wide range of biomedical research…

Software Engineering · Computer Science 2013-03-26 Oscar Mora , Jesús Bisbal

In the era of Industry 4.0, artificial intelligence (AI) is assuming an increasingly pivotal role within industrial systems. Despite the recent trend within various industries to adopt AI, the actual adoption of AI is not as developed as…

Artificial Intelligence · Computer Science 2024-06-25 Xuejiao Li , Cheng Yang , Charles Møller , Jay Lee

Feature selection, as a data preprocessing strategy, has been proven to be effective and efficient in preparing data (especially high-dimensional data) for various data mining and machine learning problems. The objectives of feature…

Machine Learning · Computer Science 2018-08-28 Jundong Li , Kewei Cheng , Suhang Wang , Fred Morstatter , Robert P. Trevino , Jiliang Tang , Huan Liu

Computational problems can be classified according to their algorithmic complexity, which is defined based on how the resources needed to solve the problem, e.g. the execution time, scale with the problem size. Many problems in…

Computational Complexity · Computer Science 2021-07-29 Davide Cirillo , Miguel Ponce-de-Leon , Alfonso Valencia

Factor analysis is a critical component of high dimensional biological data analysis. However, modern biological data contain two key features that irrevocably corrupt existing methods. First, these data, which include longitudinal,…

Methodology · Statistics 2020-09-24 Chris McKennan

Biomedical data is inherently multimodal, consisting of electronic health records, medical imaging, digital pathology, genome sequencing, wearable sensors, and more. The application of artificial intelligence tools to these multifaceted…

Machine Learning · Computer Science 2024-08-26 Shentong Mo , Paul Pu Liang

Missing data represents a fundamental challenge in machine learning applications, often reducing model performance and reliability. This problem is particularly acute in fields like bioinformatics and clinical machine learning, where…

Machine Learning · Computer Science 2025-09-04 Fatemeh Azad , Zoran Bosnić , Matjaž Kukar

Big Data in IoT is a large and fast-developing area where many different methods and techniques can play a role. Due to rapid progress in Machine Learning and new hardware developments, a dynamic turnaround of methods and technologies can…

Computers and Society · Computer Science 2019-05-03 Fayeem Aziz , Stephan K. Chalup , James Juniper

The analysis and interpretation of relationships between biological molecules is done with the help of networks. Networks are used ubiquitously throughout biology to represent the relationships between genes and gene products. Network…

Computational Engineering, Finance, and Science · Computer Science 2012-11-13 Rashmi Rameshwari , T. V. Prasad

The emergence of "big data" offers unprecedented opportunities for not only accelerating scientific advances but also enabling new modes of discovery. Scientific progress in many disciplines is increasingly enabled by our ability to examine…

Computers and Society · Computer Science 2017-07-03 Vasant G. Honavar , Mark D. Hill , Katherine Yelick

In multicenter biomedical research, integrating data from multiple decentralized sites provides more robust and generalizable findings due to its larger sample size and the ability to account for the between-site heterogeneity. However,…

Methodology · Statistics 2025-12-29 Xiaokang Liu , Yuchen Yang , Yifei Sun , Jiang Bian , Yanyuan Ma , Raymond J. Carroll , Yong Chen

Deep learning has transformed the way large and complex image datasets can be processed, reshaping what is possible in bioimage analysis. As the complexity and size of bioimage data continues to grow, this new analysis paradigm is becoming…

Quantitative Methods · Quantitative Biology 2021-08-03 Adrien Hallou , Hannah Yevick , Bianca Dumitrascu , Virginie Uhlmann

Recently, we have been witnessing huge advancements in the scale of data we routinely generate and collect in pretty much everything we do, as well as our ability to exploit modern technologies to process, analyze and understand this data.…

Databases · Computer Science 2017-09-25 Radwa Elshawi , Sherif Sakr