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In Francis and Steel (2015), it was shown that there exists non-trivial networks on $4$ leaves upon which the distance metric affords a metric on a tree which is not the base tree of the network. In this paper we extend this result in two…

Populations and Evolution · Quantitative Biology 2019-06-06 Michael Hendriksen

In this paper, we lay the groundwork on the comparison of phylogenetic networks based on edge contractions and expansions as edit operations, as originally proposed by Robinson and Foulds to compare trees. We prove that these operations…

Data Structures and Algorithms · Computer Science 2025-02-21 Bertrand Marchand , Nadia Tahiri , Olivier Tremblay-Savard , Manuel Lafond

Since Darwin, species trees have been used as a simplified description of the relationships which summarize the complicated network $N$ of reality. Recent evidence of hybridization and lateral gene transfer, however, suggest that there are…

Populations and Evolution · Quantitative Biology 2016-11-17 Stephen J. Willson

In evolutionary biology, phylogenetic networks are now widely used to represent the historical relationships between species and population, when this history includes reticulation events such as hybridization, gene flow and admixture…

Combinatorics · Mathematics 2026-05-08 Gerard Ribas , Joan Carles Pons , Cécile Ané

Phylogenetic networks are graphs that are used to represent evolutionary relationships between different taxa. They generalize phylogenetic trees since for example, unlike trees, they permit lineages to combine. Recently, there has been…

Populations and Evolution · Quantitative Biology 2025-08-05 Katharina T. Huber , Leo van Iersel , Mark Jones , Vincent Moulton , Leonie Veenema - Nipius

We study the enumeration of spinal tree-child phylogenetic networks, a rigid family of tree-child networks in which all internal vertices lie on a single root--to--leaf path. We provide two complementary combinatorial frameworks. First, we…

Combinatorics · Mathematics 2026-05-12 Pau Vives , Anna de Mier , Gabriel Cardona , Joan Carles Pons

Phylogenetic networks are generalizations of trees that allow for the modeling of non-tree like evolutionary processes. Split networks give a useful way to construct networks with intuitive distance structures induced from the associated…

Combinatorics · Mathematics 2024-09-18 Bryson Kagy , Seth Sullivant

The evolutionary relationships between species are typically represented in the biological literature by rooted phylogenetic trees. However, a tree fails to capture ancestral reticulate processes, such as the formation of hybrid species or…

Populations and Evolution · Quantitative Biology 2024-12-09 Johanna Heiss , Daniel H. Huson , Mike Steel

Phylogenetic trees canonically arise as embeddings of phylogenetic networks. We recently showed that the problem of deciding if two phylogenetic networks embed the same sets of phylogenetic trees is computationally hard, \blue{in…

Combinatorics · Mathematics 2021-04-13 Janosch Doecker , Simone Linz , Charles Semple

Unrooted phylogenetic networks are graphs used to represent evolutionary relationships. Accurately reconstructing such networks is of great relevance for evolutionary biology. It has recently been conjectured that all phylogenetic networks…

Combinatorics · Mathematics 2021-01-01 Péter L. Erdős , Leo van Iersel , Mark Jones

Phylogenetic networks are used in biology to represent evolutionary histories. The class of orchard phylogenetic networks was recently introduced for their computational benefits, without any biological justification. Here, we show that…

Combinatorics · Mathematics 2021-10-22 Leo van Iersel , Remie Janssen , Mark Jones , Yukihiro Murakami

A multi-labeled tree, or MUL-tree, is a phylogenetic tree where two or more leaves share a label, e.g., a species name. A MUL-tree can imply multiple conflicting phylogenetic relationships for the same set of taxa, but can also contain…

Data Structures and Algorithms · Computer Science 2012-06-29 Akshay Deepak , David Fernández-Baca , Michelle M. McMahon

Phylogenetics is a branch of computational biology that studies the evolutionary relationships among biological entities. Its long history and numerous applications notwithstanding, inference of phylogenetic trees from sequence data remains…

Populations and Evolution · Quantitative Biology 2024-03-26 Mingyang Zhou , Zichao Yan , Elliot Layne , Nikolay Malkin , Dinghuai Zhang , Moksh Jain , Mathieu Blanchette , Yoshua Bengio

One strategy for reconstruction of phylogenetic networks is to solve the phylogenetic network problem, which involves inferring phylogenetic trees first and subsequently computing the smallest phylogenetic network that displays all the…

Combinatorics · Mathematics 2023-09-26 Laurent Bulteau , Louxin Zhang

Reticulate evolution gives rise to complex phylogenetic networks, making their interpretation challenging. A typical approach is to extract trees within such networks. Since Francis and Steel's seminal paper, "Which Phylogenetic Networks…

Combinatorics · Mathematics 2025-05-20 Takatora Suzuki , Momoko Hayamizu

The inference of phylogenetic networks, which model complex evolutionary processes including hybridization and gene flow, remains a central challenge in evolutionary biology. Until now, statistically consistent inference methods have been…

Populations and Evolution · Quantitative Biology 2025-10-14 Niels Holtgrefe , Elizabeth S. Allman , Hector Baños , Leo van Iersel , Vincent Moulton , John A. Rhodes , Kristina Wicke

Phylogenetic networks are a generalization of evolutionary or phylogenetic trees that are commonly used to represent the evolution of species which cross with one another. A special type of phylogenetic network is an {\em $X$-cactus}, which…

Populations and Evolution · Quantitative Biology 2021-09-08 Andrew Francis , Katharina T. Huber , Vincent Moulton , Taoyang Wu

We show that the space of rooted tree-based phylogenetic networks is connected under rooted nearest-neighbour interchange (rNNI) moves.

Populations and Evolution · Quantitative Biology 2021-07-06 Péter L. Erdős , Andrew Francis , Tamás Róbert Mezei

Phylogenetic networks are notoriously difficult to reconstruct. Here we suggest that it can be useful to view unknown genetic distance along edges in phylogenetic networks as analogous to unknown resistance in electric circuits. This…

Combinatorics · Mathematics 2020-10-01 Stefan Forcey , Drew Scalzo

Neural networks are powerful function estimators, leading to their status as a paradigm of choice for modeling structured data. However, unlike other structured representations that emphasize the modularity of the problem -- e.g., factor…

Machine Learning · Computer Science 2022-06-20 Tsvetomila Mihaylova , Vlad Niculae , André F. T. Martins
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