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The effects of intrinsic noise on stochastic delay systems is studied within an expansion in the inverse system size. We show that the stochastic nature of the underlying dynamics may induce oscillatory behaviour in parameter ranges where…

Molecular Networks · Quantitative Biology 2015-05-13 Tobias Galla

We develop an approximate theoretical method to study discrete stochastic birth and death models that include a delay time. We analyze the effect of the delay in the fluctuations of the system and obtain that it can qualitatively alter…

Statistical Mechanics · Physics 2012-09-24 Luis F. Lafuerza , Raul Toral

In spatially distributed cellular systems, it is often convenient to represent complicated auxiliary pathways and spatial transport by time-delayed reaction rates. Furthermore, many of the reactants appear in low numbers necessitating a…

Quantitative Methods · Quantitative Biology 2015-05-14 Matthew Scott

Stochasticity is both exploited and controlled by cells. Although the intrinsic stochasticity inherent in biochemistry is relatively well understood, cellular variation, or 'noise', is predominantly generated by interactions of the system…

Molecular Networks · Quantitative Biology 2008-09-18 Vahid Shahrezaei , Julien F Ollivier , Peter S Swain

Time delays, modelling the process of intracellular gene expression, have been shown to have important impacts on the dynamics of pattern formation in reaction-diffusion systems. In particular, past work has shown that such time delays can…

Pattern Formation and Solitons · Physics 2022-06-28 Alec Sargood , Eamonn A. Gaffney , Andrew L. Krause

The ability of Gaussian noise to induce ordered states in dynamical systems is here presented in an overview of the main stochastic mechanisms able to generate spatial patterns. These mechanisms involve: (i) a deterministic local dynamics…

Statistical Mechanics · Physics 2012-05-14 Stefania Scarsoglio , Francesco Laio , Paolo D'Odorico , Luca Ridolfi

Regulation of intrinsic noise in gene expression is essential for many cellular functions. Correspondingly, there is considerable interest in understanding how different molecular mechanisms of gene expression impact variations in protein…

Molecular Networks · Quantitative Biology 2011-03-02 Tao Jia , Rahul V. Kulkarni

Intrinsic transcriptional noise induced by operator fluctuations is investigated with a simple spin like stochastic model. The effects of transcriptional fluctuations in protein synthesis is probed by coupling transcription and translation…

Other Quantitative Biology · Quantitative Biology 2007-05-23 Guilherme da C. P. Innocentini , Jose E. M. Hornos

Biological systems are majorly dependent on their property of bistability in order to exhibit nongenetic heterogeneity in terms of cellular morphology and physiology. Spatial patterns of phenotypically heterogeneous cells, arising due to…

Quantitative Methods · Quantitative Biology 2023-01-25 Priya Chakraborty , Ushasi Roy , Mohit K. Jolly , Sayantari Ghosh

The Notch-Delta signaling pathway mediates cell differentiation implicated in many regulatory processes including spatiotemporal patterning in tissues by promoting alternate cell fates between neighboring cells. At the multicellular level,…

Cell Behavior · Quantitative Biology 2022-10-12 Madeline Galbraith , Federico Bocci , José N. Onuchic

Water availability is a major environmental driver affecting riparian and wetland vegetation. The interaction between water table fluctuations and vegetation in a stochastic environment contributes to the complexity of the dynamics of these…

Populations and Evolution · Quantitative Biology 2012-05-14 Stefania Scarsoglio , Paolo D'Odorico , Francesco Laio , Luca Ridolfi

Effect of noise in inducing order on various chaotically evolving systems is reviewed, with special emphasis on systems consisting of coupled chaotic elements. In many situations it is observed that the uncoupled elements when driven by…

chao-dyn · Physics 2015-06-24 Manojit Roy , R. E. Amritkar

In small volumes, the kinetics of filamentous protein self-assembly is expected to show significant variability, arising from intrinsic molecular noise. This is not accounted for in existing deterministic models. We introduce a simple…

Soft Condensed Matter · Physics 2014-08-28 Juraj Szavits-Nossan , Kym Eden , Ryan J. Morris , Cait E. MacPhee , Martin R. Evans , Rosalind J. Allen

We propose here a stochastic binary element whose transition rate depends on its state at a fixed interval in the past. With this delayed stochastic transition this is one of the simplest dynamical models under the influence of ``noise''…

Statistical Mechanics · Physics 2009-10-31 Toru Ohira , Yuzuru Sato

Spatiotemporal patterns are common in biological systems. For electrically-coupled cells previous studies of pattern formation have mainly used external forcing as the main bifurcation parameter. The purpose of this paper is to show that…

Dynamical Systems · Mathematics 2021-11-02 H. O. Fatoyinbo , R. G. Brown , D. J. W. Simpson , B. van Brunt

We investigate noise-induced pattern formation in a model of cancer growth based on Michaelis-Menten kinetics, subject to additive and multiplicative noises. We analyse stability properties of the system and discuss the role of diffusion…

Cell Behavior · Quantitative Biology 2007-05-23 Anna Ochab-Marcinek

We propose a new non-equilibrium model for spatial pattern formation on the basis of local information transfer. Unlike standard models of pattern formation it is not based on the Turing instability. Information is transmitted through the…

Statistical Mechanics · Physics 2007-05-23 Thimo Rohlf , Stefan Bornholdt

The development of new techniques to quantitatively measure gene expression in cells has shed light on a number of systems that display oscillations in protein concentration. Here we review the different mechanisms which can produce…

Molecular Networks · Quantitative Biology 2009-11-13 G. Tiana , S. Krishna , S. Pigolotti , M. H. Jensen , K. Sneppen

Gene products (RNAs, proteins) often occur at low molecular counts inside individual cells, and hence are subject to considerable random fluctuations (noise) in copy number over time. Not surprisingly, cells encode diverse regulatory…

Molecular Networks · Quantitative Biology 2015-10-01 Thierry Platini , Mohammad Soltani , Abhyudai Singh

We study the effects of noise on the dynamics of a system of coupled self-propelling particles in the case where the coupling is time-delayed, and the delays are discrete and randomly generated. Previous work has demonstrated that the…

Pattern Formation and Solitons · Physics 2012-10-08 Brandon Lindley , Luis Mier-y-Teran-Romero , Ira B. Schwartz
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