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Biologists use random transposon mutagenesis to construct knockout libraries for bacteria. Random mutagenesis offers cost and efficiency benefits over the standard site directed mutagenesis, but one can no longer ensure that all the…

Other Quantitative Biology · Quantitative Biology 2007-05-23 Oliver Will , Michael A Jacobs

Most of major algorithms for phylogenetic tree reconstruction assume that sequences in the analyzed set either do not have any offspring, or that parent sequences can maximally mutate into just two descendants. The graph resulting from such…

Populations and Evolution · Quantitative Biology 2013-10-09 Piotr Plonski , Jan P. Radomski

We propose a novel sequence prediction method for sequential data capturing node traversals in graphs. Our method builds on a statistical modelling framework that combines multiple higher-order network models into a single multi-order…

Machine Learning · Computer Science 2023-10-25 Christoph Gote , Giona Casiraghi , Frank Schweitzer , Ingo Scholtes

Working with exhaustive search on large dataset is infeasible for several reasons. Recently, developed techniques that made pattern set mining feasible by a general solver with long execution time that supports heuristic search and are…

Artificial Intelligence · Computer Science 2015-07-21 Shanjida Khatun , Hasib Ul Alam , Swakkhar Shatabda

The deep Convolutional Neural Network (CNN) is the state-of-the-art solution for large-scale visual recognition. Following basic principles such as increasing the depth and constructing highway connections, researchers have manually…

Computer Vision and Pattern Recognition · Computer Science 2017-03-07 Lingxi Xie , Alan Yuille

Exploration of task mappings plays a crucial role in achieving high performance in heterogeneous multi-processor system-on-chip (MPSoC) platforms. The problem of optimally mapping a set of tasks onto a set of given heterogeneous processors…

Performance · Computer Science 2014-07-01 Wei Quan , Andy D. Pimentel

In many situations, the gene expression signature is a unique marker of the biological state. We study the modification of the gene expression distribution function when the biological state of a system experiences a change. This change may…

Quantitative Methods · Quantitative Biology 2022-05-19 Augusto Gonzalez , Joan Nieves , Maria Luisa Bringas Vega , Pedro Valdes Sosa

Very long and noisy sequence data arise from biological sciences to social science including high throughput data in genomics and stock prices in econometrics. Often such data are collected in order to identify and understand shifts in…

Methodology · Statistics 2016-07-15 Yue S. Niu , Ning Hao , Heping Zhang

Technical signs of progress during the last decades has led to a situation in which the accumulation of genome sequence data is increasingly fast and cheap. The huge amount of molecular data available nowadays can help addressing new and…

Genomics · Quantitative Biology 2017-05-02 Christophe Guyeux , Bashar Al-Nuaimi , Bassam AlKindy , Jean-François Couchot , Michel Salomon

Transposed elements (TEs) are mobile genetic sequences. During the evolution of eukaryotes TEs were inserted into active protein-coding genes, affecting gene structure, expression and splicing patterns, and protein sequences. Genomic…

Genomics · Quantitative Biology 2008-11-24 Asaf Levy , Noa Sela , Gil Ast

In this thesis, we develop various techniques for working with sets in machine learning. Each input or output is not an image or a sequence, but a set: an unordered collection of multiple objects, each object described by a feature vector.…

Machine Learning · Computer Science 2021-03-09 Yan Zhang

In first-passage percolation, one places nonnegative i.i.d. random variables (T (e)) on the edges of Z d. A geodesic is an optimal path for the passage times T (e). Consider a local property of the time environment. We call it a pattern. We…

Probability · Mathematics 2023-03-09 Antonin Jacquet

We study the evolution of artificial learning systems by means of selection. Genetic programming is used to generate a sequence of populations of algorithms which can be used by neural networks for supervised learning of a rule that…

Biological Physics · Physics 2009-11-07 Juan Pablo Neirotti , Nestor Caticha

In this thesis we consider ordered graphs (that is, graphs with a fixed linear ordering on their vertices). We summarize and further investigations on the number of edges an ordered graph may have while avoiding a fixed forbidden ordered…

Discrete Mathematics · Computer Science 2009-07-16 Craig Weidert

Biomolecular networks have already found great utility in characterizing complex biological systems arising from pair-wise interactions amongst biomolecules. Here, we review how graph theoretical approaches can be applied not only for a…

Molecular Networks · Quantitative Biology 2018-12-03 Heeralal Janwa , Steven E. Massey , Julian Velev , Bud Mishra

Evolution has fascinated quantitative and physical scientists for decades: how can the random process of mutation, recombination, and duplication of genetic information generate the diversity of life? What determines the rate of evolution?…

Populations and Evolution · Quantitative Biology 2018-04-23 Richard A. Neher , Aleksandra M. Walczak

In this article we provide a comprehensive review of the different evolutionary algorithm techniques used to address multimodal optimization problems, classifying them according to the nature of their approach. On the one hand there are…

Neural and Evolutionary Computing · Computer Science 2015-08-24 Noe Casas

Stepwise inference protocols, such as scratchpads and chain-of-thought, help language models solve complex problems by decomposing them into a sequence of simpler subproblems. Despite the significant gain in performance achieved via these…

Machine Learning · Computer Science 2024-02-13 Mikail Khona , Maya Okawa , Jan Hula , Rahul Ramesh , Kento Nishi , Robert Dick , Ekdeep Singh Lubana , Hidenori Tanaka

In many applications, it is needed to change the topology of a tensor network directly and without approximation. This work will introduce a general scheme that satisfies these needs. We will describe the procedure by two examples and show…

Numerical Analysis · Mathematics 2012-03-08 Stefan Handschuh

The prevalent approach to sequence to sequence learning maps an input sequence to a variable length output sequence via recurrent neural networks. We introduce an architecture based entirely on convolutional neural networks. Compared to…

Computation and Language · Computer Science 2017-07-26 Jonas Gehring , Michael Auli , David Grangier , Denis Yarats , Yann N. Dauphin
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