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Bacterial chromosome replication occurs in the absence of a canonical spindle apparatus; yet it reliably produces organised and segregated genomes. While both passive and active mechanisms have been investigated, DNA replication itself is a…

Biological Physics · Physics 2026-04-02 Giada Forte , Enzo Orlandini , Davide Marenduzzo

The three-dimensional organisation of chromosomes can be probed using methods such as Capture-C. However it is unclear how such population level data relates to the organisation within a single cell, and the mechanisms leading to the…

Quantitative Methods · Quantitative Biology 2016-01-13 Chris A Brackley , Jill M Brown , Dominic Waithe , Christian Babbs , James Davies , Jim R Hughes , Veronica J Buckle , Davide Marenduzzo

Recent work has shown that two seemingly different physical mechanisms, namely fracton behavior and confinement, can give rise to non-ergodicity in one-dimensional quantum many-body systems. In this work, we demonstrate an intrinsic link…

Strongly Correlated Electrons · Physics 2020-02-05 Shriya Pai , Michael Pretko

The connection between chromatin nuclear organization and gene activity is vividly illustrated by the observation that transcriptional coregulation of certain genes appears to be directly influenced by their spatial proximity. This fact…

Genomics · Quantitative Biology 2015-06-15 Marco Di Stefano , Angelo Rosa , Vincenzo Belcastro , Diego di Bernardo , Cristian Micheletti

We perform extensive numerical simulations of a paradigmatic model glass former, the hard-sphere fluid with 10% polydispersity. We sample from the ensemble of trajectories with fixed observation time, whereby single trajectories are…

Statistical Mechanics · Physics 2020-01-28 Matteo Campo , Thomas Speck

We present results from molecular dynamics simulations exploring the supercooled dynamics of the Gaussian Core Model in the low- and intermediate-density regimes. In particular, we discuss the transition from the low-density…

Soft Condensed Matter · Physics 2024-03-18 Vittoria Sposini , Christos N. Likos , Manuel Camargo

The formation of (bio)molecular condensates via liquid-liquid phase separation in cells has received increasing attention, as these coacervates play important functional and regulatory roles within biological systems. However, the majority…

Soft Condensed Matter · Physics 2022-11-24 Arash Nikoubashman , Miho Yanagisawa

Graphene nanochannels are relevant for their possible applications, as in water purification, and for the challenge of understanding how they change the properties of confined liquids. Here, we use all-atom molecular dynamics simulations to…

Soft Condensed Matter · Physics 2021-03-25 Carles Calero , Giancarlo Franzese

We address the crystallization of monodisperse hard spheres in terms of the properties of finite- size crystalline clusters. By means of large scale event-driven Molecular Dynamics simulations, we study systems at different packing…

In living cells, proteins involved in specialized biochemical functions are often spatially organized within biomolecular condensates. Increasing evidence suggests that some of these condensates, including DNA repair condensates, emerge…

Soft Condensed Matter · Physics 2026-05-15 Léa Beaulès , Judith Miné-Hattab , Pierre Illien , Vincent Dahirel

When classical systems fail to explore their entire configurational space, intriguing macroscopic phenomena like aging and glass formation may emerge. Also closed quanto-mechanical systems may stop wandering freely around the whole Hilbert…

Statistical Mechanics · Physics 2012-02-07 Giuseppe Carleo , Federico Becca , Marco Schiró , Michele Fabrizio

We study jammed configurations of hard spheres as a function of compression speed using an event-driven molecular dynamics algorithm. We find that during the compression, the pressure follows closely the metastable liquid branch until the…

Soft Condensed Matter · Physics 2016-05-19 Michiel Hermes , Marjolein Dijkstra

Dynamics is central to living systems. In the last two decades, experiments have revealed that the dynamics in diverse biological systems - from intracellular cytoplasm to cellular and organismal aggregates - are remarkably similar to that…

Soft Condensed Matter · Physics 2024-03-12 Souvik Sadhukhan , Subhodeep Dey , Smarajit Karmakar , Saroj Kumar Nandi

Confinement of atoms inside various cavities has been studied for nearly eight decades. However, the Compton profile for such systems has not yet been investigated. Here we construct the Compton profile (CP) for a H atom radially confined…

Quantum Physics · Physics 2021-03-01 Neetik Mukherjee , Amlan K. Roy

Shell confined atom can serve as a generalized model to explain both \emph{free} and \emph{confined} condition. In this scenario, an atom is trapped inside two concentric spheres of inner $(R_{a})$ and outer $(R_{b})$ radius. The choice of…

Quantum Physics · Physics 2022-05-19 Neetik Mukherjee , Amlan K. Roy

Recently single molecule experiments have shown the importance of internal friction in biopolymer dynamics. Such studies also suggested that the internal friction although independent of solvent viscosity has strong dependence on denaturant…

Soft Condensed Matter · Physics 2015-06-02 Nairhita Samanta , Rajarshi Chakrabarti

We study bidisperse colloidal suspensions confined within glass microcapillary tubes to model the glass transition in confined cylindrical geometries. We use high speed three-dimensional confocal microscopy to observe particle motions for a…

Soft Condensed Matter · Physics 2013-02-28 Nabiha Saklayen , Gary L. Hunter , Kazem V. Edmond , Eric R. Weeks

Spherical confinement can act either stabilizing or destabilizing on the collapsed state of a semi-flexible polymer. General free-energy arguments suggest that the order of the unconstrained collapse transition is the distinguishing factor:…

Soft Condensed Matter · Physics 2018-11-14 Martin Marenz , Johannes Zierenberg , Wolfhard Janke

Using molecular dynamics simulations, we show that a widely-accepted theoretical prediction for glassy-polymeric strain hardening moduli ($G_R \propto \rho_e$, where $\rho_e$ is the entanglement density) fails badly for semiflexible…

Soft Condensed Matter · Physics 2025-11-24 Robert S. Hoy

The binary hard-sphere mixture is one of the simplest representations of a many-body system with competing time and length scales. This model is relevant to fundamentally understand both the structural and dynamical properties of materials,…

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