Related papers: Fundamental Limits to Cellular Sensing
Information of relevance to the organism often is represented by the concentrations of particular molecules inside a cell. As outside observers we can now measure these concentrations precisely, but the cell's own mechanisms must be…
Neural correlations play a critical role in sensory information coding. They are of two kinds: signal correlations, when neurons have overlapping sensitivities, and noise correlations from network effects and shared noise. In experiments…
The resolution of resonant sensors is fundamentally limited by the presence of noise. Thermomechanical noise, intrinsic to the resonator, sets the ultimate sensor performance when all other noise sources have been eliminated. For linear…
In the first part of the series papers, we set out to answer the following question: given specific restrictions on a set of samplers, what kind of signal can be uniquely represented by the corresponding samples attained, as the foundation…
Living cells sense their environment through the binding of extra-cellular molecular ligands to cell surface receptors. Puzzlingly, vast numbers of signaling pathways exhibit a high degree of cross talk between different signals whereby…
A discrete time stochastic feedback control system with a noisy communication channel between the sensor and the controller is considered. The sensor has limited memory. At each time, the sensor transmits encoded symbol over the channel and…
Quantum sensors hold considerable promise for precision measurement, yet their capabilities are inherently constrained by environmental noise. A fundamental task in quantum sensing is determining the precision limit of noisy sensor devices.…
In theory coordinated multi-point transmission (CoMP) promises vast gains in spectral efficiency. But industrial field trials show rather disappointing throughput gains, whereby the major limiting factor is proper sharing of channel state…
Unconventional receivers enable reduction of error rates in optical communication systems below the standard quantum limit (SQL) by implementing discrimination strategies for constellation symbols that go beyond the canonical measurement of…
Unconventional properties of non-Hermitian systems, such as the existence of exceptional points, have recently been suggested as a resource for sensing. The impact of noise and utility in quantum regimes however remains unclear. In this…
This paper gives a precise characterization of the fundamental limits of adaptive sensing for diverse estimation and testing problems concerning sparse signals. We consider in particular the setting introduced in (IEEE Trans. Inform. Theory…
Eukaryotic cells generally sense chemical gradients using the binding of chemical ligands to membrane receptors. In order to perform chemotaxis effectively in different environments, cells need to adapt to different concentrations. We…
We study the information loss of a class of inference strategies that is solely based on time averaging. For an array of independent binary sensors (e.g., receptors, single electron transistors) measuring a weak random signal (e.g., ligand…
When a single cell senses a chemical gradient and chemotaxes, stochastic receptor-ligand binding can be a fundamental limit to the cell's accuracy. For clusters of cells responding to gradients, however, there is a critical difference: even…
Changes in a cell's external or internal conditions are usually reflected in the concentrations of the relevant transcription factors. These proteins in turn modulate the expression levels of the genes under their control and sometimes need…
Future space observatories achieve detection of gravitational waves by interferometric measurements of a carrier phase, allowing to determine relative distance changes, in combination with an absolute distance measurement based on the…
Extremely large-scale antenna arrays (ELAAs) envisioned for 6G enable high-resolution sensing. However, the ELAAs worked in extremely high frequency will push operation into the near-field region, where spherical wavefronts invalidate…
In this paper, we design matched filters for diffusive molecular communication systems taking into account the following impairments: signal-dependent diffusion noise, inter-symbol interference (ISI), and external interfering molecules. The…
The analyses of cellular network performance based on stochastic geometry generally ignore the traffic dynamics in the network. This restricts the proper evaluation and dimensioning of the network from the perspective of a mobile operator.…
Organisms use specialized sensors to measure their environments, but the fundamental principles that determine their accuracy remain largely unknown. In Escherichia coli chemotaxis, we previously found that gradient-climbing speed is…