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Cell image analysis is crucial in Alzheimer's research to detect the presence of A$\beta$ protein inhibiting cell function. Deep learning speeds up the process by making only low-level data sufficient for fruitful inspection. We first found…

Image and Video Processing · Electrical Eng. & Systems 2021-08-04 Wooseok Jung

This paper is motivated by the joint analysis of genetic, imaging, and clinical (GIC) data collected in the Alzheimer's Disease Neuroimaging Initiative (ADNI) study. We propose a regression framework based on partially functional linear…

Methodology · Statistics 2023-02-23 Ting Li , Yang Yu , J. S. Marron , Hongtu Zhu

Tensors provide a robust framework for managing high-dimensional data. Consequently, tensor analysis has emerged as an active research area in various domains, including machine learning, signal processing, computer vision, graph analysis,…

Computation · Statistics 2025-10-01 Michele Gallo

Previous works in the literature apply 3D spatial-only models on 4D functional MRI data leading to possible sub-par feature extraction to be used for downstream tasks like classification. In this work, we aim to develop a novel 4D…

Image and Video Processing · Electrical Eng. & Systems 2025-06-04 Javier Salazar Cavazos , Scott Peltier

Representation learning on large-scale unstructured volumetric and surface meshes poses significant challenges in neuroimaging, especially when models must incorporate diverse vertex-level morphometric descriptors, such as cortical…

Computer Vision and Pattern Recognition · Computer Science 2026-04-08 Yujian Xiong , Mohammad Farazi , Yanxi Chen , Wenhui Zhu , Xuanzhao Dong , Natasha Lepore , Yi Su , Raza Mushtaq , Stephen Foldes , Andrew Yang , Yalin Wang

Marginal Structural Models (MSMs) are popular for causal inference of sequential treatments in longitudinal observational studies, which however are sensitive to model misspecification. To achieve flexible modeling, we envision the…

Methodology · Statistics 2025-11-21 Chenyin Gao , Han Chen , Anru R. Zhang , Shu Yang

Information from neuroimaging examinations is increasingly used to support diagnoses of dementia, e.g., Alzheimer's disease. While current clinical practice is mainly based on visual inspection and feature engineering, Deep Learning…

Computer Vision and Pattern Recognition · Computer Science 2024-07-23 Lisa Anita De Santi , Jörg Schlötterer , Michael Scheschenja , Joel Wessendorf , Meike Nauta , Vincenzo Positano , Christin Seifert

Alzheimers Disease (AD) is a progressive neurodegenerative disorder that poses significant challenges in its early diagnosis, often leading to delayed treatment and poorer outcomes for patients. Traditional diagnostic methods, typically…

Machine Learning · Computer Science 2025-08-06 Tatwadarshi P Nagarhalli , Sanket Patil , Vishal Pande , Uday Aswalekar , Prafulla Patil

With rapid advances in neuroimaging techniques, the research on brain disorder identification has become an emerging area in the data mining community. Brain disorder data poses many unique challenges for data mining research. For example,…

Machine Learning · Computer Science 2015-08-06 Bokai Cao , Xiangnan Kong , Philip S. Yu

Although recent deep learning methods, especially generative models, have shown good performance in fast magnetic resonance imaging, there is still much room for improvement in high-dimensional generation. Considering that internal…

Computer Vision and Pattern Recognition · Computer Science 2022-12-13 Wei Zhang , Zengwei Xiao , Hui Tao , Minghui Zhang , Xiaoling Xu , Qiegen Liu

Tensor decomposition of high-dimensional data often struggles to capture semantically or physically meaningful structures, particularly when relying on reconstruction objectives and fixed-rank constraints. We introduce a no-rank tensor…

Machine Learning · Computer Science 2026-03-03 Maryam Bagherian

The classical vector autoregressive model is a fundamental tool for multivariate time series analysis. However, it involves too many parameters when the number of time series and lag order are even moderately large. This paper proposes to…

Methodology · Statistics 2020-11-04 Di Wang , Yao Zheng , Heng Lian , Guodong Li

The tensor-train (TT) format is a data-sparse tensor representation commonly used in high dimensional function approximations arising from computational and data sciences. Various sequential and parallel TT decomposition algorithms have…

Numerical Analysis · Mathematics 2025-09-05 Tianyi Shi , Daniel Hayes , Jing-Mei Qiu

The advent of the Internet era has led to an explosive growth in the Electronic Health Records (EHR) in the past decades. The EHR data can be regarded as a collection of clinical events, including laboratory results, medication records,…

Machine Learning · Computer Science 2019-11-14 Zichang Wang , Haoran Li , Luchen Liu , Haoxian Wu , Ming Zhang

Computer-aided early diagnosis of Alzheimers Disease (AD) and its prodromal form, Mild Cognitive Impairment (MCI), has been the subject of extensive research in recent years. Some recent studies have shown promising results in the AD and…

Computer Vision and Pattern Recognition · Computer Science 2018-01-19 Alexander Khvostikov , Karim Aderghal , Jenny Benois-Pineau , Andrey Krylov , Gwenaelle Catheline

A mediation analysis approach is proposed for multiple exposures, multiple mediators, and a continuous scalar outcome under the linear structural equation modeling framework. It assumes that there exist orthogonal components that…

Methodology · Statistics 2022-09-12 Yi Zhao

Disease progression modeling (DPM) using longitudinal data is a challenging machine learning task. Existing DPM algorithms neglect temporal dependencies among measurements, make parametric assumptions about biomarker trajectories, do not…

Computer Vision and Pattern Recognition · Computer Science 2019-03-19 Mostafa Mehdipour Ghazi , Mads Nielsen , Akshay Pai , M. Jorge Cardoso , Marc Modat , Sebastien Ourselin , Lauge Sørensen

A full parametric and linear specification may be insufficient to capture complicated patterns in studies exploring complex features, such as those investigating age-related changes in brain functional abilities. Alternatively, a partially…

Methodology · Statistics 2024-02-07 Jia Liang , Shuo Chen , Peter Kochunov , L Elliot Hong , Chixiang Chen

Accurate diagnosis of Alzheimer's disease (AD) requires handling tabular biomarker data, yet such data are often small and incomplete, where deep learning models frequently fail to outperform classical methods. Pretrained large language…

Computation and Language · Computer Science 2026-03-19 Sophie Kearney , Shu Yang , Zixuan Wen , Weimin Lyu , Bojian Hou , Duy Duong-Tran , Tianlong Chen , Jason H. Moore , Marylyn D. Ritchie , Chao Chen , Li Shen

For a nonlinear dynamical system that depends on parameters, the paper introduces a novel tensorial reduced-order model (TROM). The reduced model is projection-based, and for systems with no parameters involved, it resembles proper…

Numerical Analysis · Mathematics 2023-11-16 Alexander V. Mamonov , Maxim A. Olshanskii