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Alzheimer's Disease is a devastating neurological disorder that is increasingly affecting the elderly population. Early and accurate detection of Alzheimer's is crucial for providing effective treatment and support for patients and their…

Image and Video Processing · Electrical Eng. & Systems 2023-04-27 Krishna Mahapatra , Selvakumar R

Deep learning has shown significant potential in diagnosing neurodegenerative diseases from MRI data. However, most existing methods rely heavily on large volumes of labeled data and often yield representations that lack interpretability.…

Computer Vision and Pattern Recognition · Computer Science 2025-09-10 Fangqi Cheng , Yingying Zhao , Xiaochen Yang

Deep learning has emerged as a promising approach for learning the nonlinear mapping between diffusion-weighted MR images and tissue parameters, which enables automatic and deep understanding of the brain microstructures. However, the…

Computer Vision and Pattern Recognition · Computer Science 2025-05-21 Wenxin Fan , Jian Cheng , Qiyuan Tian , Ruoyou Wu , Juan Zou , Zan Chen , Shanshan Wang

Disease in the brain is often associated with subtle, spatially diffuse, or complex tissue changes that may lie beneath the level of gross visual inspection, even on magnetic resonance imaging (MRI). Unfortunately, current computer-assisted…

Computer Vision and Pattern Recognition · Computer Science 2017-05-16 Shinjini Kundu , Soheil Kolouri , Kirk I Erickson , Arthur F Kramer , Edward McAuley , Gustavo K Rohde

The growing use of neuroimaging technologies generates a massive amount of biomedical data that exhibit high dimensionality. Tensor-based analysis of brain imaging data has been proved quite effective in exploiting their multiway nature.…

Numerical Analysis · Computer Science 2016-07-21 Christos Chatzichristos , Eleftherios Kofidis , Giannis Kopsinis , Sergios Theodoridis

With the increasing availability of various sensor technologies, we now have access to large amounts of multi-block (also called multi-set, multi-relational, or multi-view) data that need to be jointly analyzed to explore their latent…

Computational Engineering, Finance, and Science · Computer Science 2015-09-01 Guoxu Zhou , Qibin Zhao , Yu Zhang , Tülay Adalı , Shengli Xie , Andrzej Cichocki

Machine learning methods have shown large potential for the automatic early diagnosis of Alzheimer's Disease (AD). However, some machine learning methods based on imaging data have poor interpretability because it is usually unclear how…

Radio-frequency (RF) tomographic imaging is a promising technique for inferring multi-dimensional physical space by processing RF signals traversed across a region of interest. However, conventional RF tomography schemes are generally based…

Information Theory · Computer Science 2017-12-19 Tao Deng , Xiao-Yang Liu , Feng Qian , Anwar Walid

Additive models can be used for interpretable machine learning for their clarity and simplicity. However, In the classical models for high-order data, the vectorization operation disrupts the data structure, which may lead to degenerated…

Machine Learning · Computer Science 2024-06-06 Yang Chen , Ce Zhu , Jiani Liu , Yipeng Liu

Mixed Models for Repeated Measures (MMRMs) are ubiquitous when analyzing outcomes of clinical trials. However, the linearity of the fixed-effect structure in these models largely restrict their use to estimating treatment effects that are…

Methodology · Statistics 2023-01-23 Lars Lau Raket

As a general and robust alternative to traditional mean regression models, quantile regression avoids the assumption of normally distributed errors, making it a versatile choice when modeling outcomes such as cognitive scores that typically…

Methodology · Statistics 2026-03-19 Rongke Lyu , Marina Vannucci , Suprateek Kundu

We address prediction problems on tabular categorical data, where each instance is defined by multiple categorical attributes, each taking values from a finite set. These attributes are often referred to as fields, and their categorical…

In this paper, we provide an extensive overview of machine learning techniques applied to structural magnetic resonance imaging (MRI) data to obtain clinical classifiers. We specifically address practical problems commonly encountered in…

Quantitative Methods · Quantitative Biology 2018-08-20 José María Mateos-Pérez , Mahsa Dadar , María Lacalle-Aurioles , Yasser Iturria-Medina , Yashar Zeighami , Alan C. Evans

Alzheimer's disease is characterised by the spreading of misfolded proteins and progressive structural changes in the brain. Despite significant clinical research, understanding how microscopic protein dynamics translate into macroscopic…

Computational Engineering, Finance, and Science · Computer Science 2026-03-23 A. Vazquez-Palomo , C. Betegón , J. Weickenmeier , E. Martínez-Pañeda

Hidden Markov models (HMMs) are commonly used for disease progression modeling when the true patient health state is not fully known. Since HMMs typically have multiple local optima, incorporating additional patient covariates can improve…

Machine Learning · Statistics 2021-10-05 Matt Baucum , Anahita Khojandi , Theodore Papamarkou

Stacking excessive layers in DNN results in highly underdetermined system when training samples are limited, which is very common in medical applications. In this regard, we present a framework capable of deriving an efficient…

Machine Learning · Computer Science 2025-03-04 Seunghun Baek , Injun Choi , Mustafa Dere , Minjeong Kim , Guorong Wu , Won Hwa Kim

We introduce a temporal feature encoding architecture called Time Series Representation Model (TSRM) for multivariate time series forecasting and imputation. The architecture is structured around CNN-based representation layers, each…

Machine Learning · Computer Science 2025-04-29 Robert Leppich , Michael Stenger , Daniel Grillmeyer , Vanessa Borst , Samuel Kounev

Tensor-based morphometry (TBM) aims at showing local differences in brain volumes with respect to a common template. TBM images are smooth but they exhibit (especially in diseased groups) higher values in some brain regions called lateral…

We study the low-rank phase retrieval problem, where the objective is to recover a sequence of signals (typically images) given the magnitude of linear measurements of those signals. Existing solutions involve recovering a matrix…

Image and Video Processing · Electrical Eng. & Systems 2022-02-18 Soo Min Kwon , Xin Li , Anand D. Sarwate

Accurate early diagnosis and monitoring of neurodegenerative conditions is essential for effective disease management and delivery of medication and treatment. This research develops automatic methods for detecting brain imaging preclinical…

Neural and Evolutionary Computing · Computer Science 2019-10-15 Amir Dehsarvi , Stephen L. Smith