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Microarray data analysis is one of the major area of research in the field computational biology. Numerous techniques like clustering, biclustering are often applied to microarray data to extract meaningful outcomes which play key roles in…

Neural and Evolutionary Computing · Computer Science 2019-09-04 Shubhankar Mohapatra , Moumita Sarkar , Anjali Mohapatra , Bhawani Sankar Biswal

Cluster-randomized experiments are widely used due to their logistical convenience and policy relevance. To analyze them properly, we must address the fact that the treatment is assigned at the cluster level instead of the individual level.…

Methodology · Statistics 2021-08-06 Fangzhou Su , Peng Ding

Recently, it has become feasible to generate large-scale, multi-tissue gene expression data, where expression profiles are obtained from multiple tissues or organs sampled from dozens to hundreds of individuals. When traditional clustering…

Quantitative Methods · Quantitative Biology 2021-10-29 Pau Erola , Johan LM Björkegren , Tom Michoel

Experimental studies are a cornerstone of Machine Learning (ML) research. A common and often implicit assumption is that the study's results will generalize beyond the study itself, e.g., to new data. That is, repeating the same study under…

Machine Learning · Computer Science 2025-12-05 Federico Matteucci , Vadim Arzamasov , Jose Cribeiro-Ramallo , Marco Heyden , Konstantin Ntounas , Klemens Böhm

Modern scientific studies often collect data sets in the forms of tensors, which call for innovative statistical analysis methods. In particular, there is a pressing need for tensor clustering methods to understand the heterogeneity in the…

Methodology · Statistics 2021-04-27 Qing Mai , Xin Zhang , Yuqing Pan , Kai Deng

Diffusion models have emerged as a powerful framework for generative tasks in deep learning. They decompose generative modeling into two computational primitives: deterministic neural-network evaluation and stochastic sampling. Current…

Machine Learning · Computer Science 2026-03-31 Nihal Sanjay Singh , Mazdak Mohseni-Rajaee , Shaila Niazi , Kerem Y. Camsari

As single-cell gene expression data analysis continues to grow, the need for reliable clustering methods has become increasingly important. The prevalence of heuristic means for method choice could lead to inaccurate reports if…

Quantitative Methods · Quantitative Biology 2026-05-19 Owen Visser , Somnath Datta

We address the problem of data clustering by introducing an unsupervised, parameter free approach based on maximum likelihood principle. Starting from the observation that data sets belonging to the same cluster share a common information,…

Statistical Mechanics · Physics 2009-11-07 Lorenzo Giada , Matteo Marsili

We propose an algorithm for clustering high dimensional data. If $P$ features for $N$ objects are represented in an $N\times P$ matrix ${\bf X}$, where $N\ll P$, the method is based on exploiting the cluster-dependent structure of the…

Machine Learning · Statistics 2018-11-05 Shahina Rahman , Valen E. Johnson

We propose a simple and efficient clustering method for high-dimensional data with a large number of clusters. Our algorithm achieves high-performance by evaluating distances of datapoints with a subset of the cluster centres. Our…

Machine Learning · Computer Science 2022-03-30 Georgios Exarchakis , Omar Oubari , Gregor Lenz

Differentially private (DP) language model inference is an approach for generating private synthetic text. A sensitive input example is used to prompt an off-the-shelf large language model (LLM) to produce a similar example. Multiple…

Machine Learning · Computer Science 2025-06-06 Kareem Amin , Salman Avestimehr , Sara Babakniya , Alex Bie , Weiwei Kong , Natalia Ponomareva , Umar Syed

In an age of increasingly large data sets, investigators in many different disciplines have turned to clustering as a tool for data analysis and exploration. Existing clustering methods, however, typically depend on several nontrivial…

Quantitative Methods · Quantitative Biology 2009-11-11 Noam Slonim , Gurinder Singh Atwal , Gasper Tkacik , William Bialek

We introduce a novel end-to-end approach for learning to cluster in the absence of labeled examples. Our clustering objective is based on optimizing normalized cuts, a criterion which measures both intra-cluster similarity as well as…

Machine Learning · Computer Science 2019-10-18 Azade Nazi , Will Hang , Anna Goldie , Sujith Ravi , Azalia Mirhoseini

Mixture models extend the toolbox of clustering methods available to the data analyst. They allow for an explicit definition of the cluster shapes and structure within a probabilistic framework and exploit estimation and inference…

Methodology · Statistics 2025-09-15 Bettina Grün

There is a wide variety of data mining methods available, and it is generally useful in exploratory data analysis to use many different methods for the same dataset. This, however, leads to the problem of whether the results found by one…

Machine Learning · Computer Science 2020-06-18 Sami Hanhijärvi , Markus Ojala , Niko Vuokko , Kai Puolamäki , Nikolaj Tatti , Heikki Mannila

The search of information in large text repositories has been plagued by the so-called document-query vocabulary gap, i.e. the semantic discordance between the contents in the stored document entities on the one hand and the human query on…

Information Retrieval · Computer Science 2020-04-22 Bhawani Selvaretnam , Mohammed Belkhatir

We introduce an unsupervised approach to efficiently discover the underlying features in a data set via crowdsourcing. Our queries ask crowd members to articulate a feature common to two out of three displayed examples. In addition we also…

Machine Learning · Statistics 2015-04-02 James Y. Zou , Kamalika Chaudhuri , Adam Tauman Kalai

Exploiting the information provided by the molecular noise of a biological process has proven to be valuable in extracting knowledge about the underlying kinetic parameters and sources of variability from single cell measurements. However,…

Quantitative Methods · Quantitative Biology 2013-08-30 Jakob Ruess , Andreas Milias-Argeitis , John Lygeros

Active learning selects the most informative samples from the unlabelled dataset to annotate in the context of a limited annotation budget. While numerous methods have been proposed for subsequent sample selection based on an initialized…

Machine Learning · Computer Science 2024-03-28 Han Yuan , Chuan Hong

The literature on clustering for continuous data is rich and wide; differently, that one developed for categorical data is still limited. In some cases, the problem is made more difficult by the presence of noise variables/dimensions that…

Methodology · Statistics 2015-04-14 Monia Ranalli , Roberto Rocci