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Synfire chains are thought to underlie precisely-timed sequences of spikes observed in various brain regions and across species. How they are formed is not understood. Here we analyze self-organization of synfire chains through the…

Neurons and Cognition · Quantitative Biology 2015-06-16 Aaron Miller , Dezhe Z. Jin

Spike-Timing-Dependent Plasticity (STDP) provides a biologically grounded learning rule for spiking neural networks (SNNs), but its reliance on precise spike timing and pairwise updates limits fast learning of weights. We introduce a…

Neural and Evolutionary Computing · Computer Science 2026-01-14 Gouri Lakshmi S , Athira Chandrasekharan , Harshit Kumar , Muhammed Sahad E , Bikas C Das , Saptarshi Bej

Neurons in the nervous system are submitted to distinct sources of noise, such as ionic-channel and synaptic noise, which introduces variability in their responses to repeated presentations of identical stimuli. This motivates the use of…

Short-Term Synaptic Plasticity (STSP) strongly affects the neural dynamics of cortical networks. The Tsodyks and Markram (TM) model for STSP accurately accounts for a wide range of physiological responses at different types of cortical…

Neurons and Cognition · Quantitative Biology 2014-03-05 Jesus M Cortes , Mathieu Desroches , Serafim Rodrigues , Romain Veltz , Miguel A. Munoz , Terrence J. Sejnowski

Identifying, formalizing and combining biological mechanisms which implement known brain functions, such as prediction, is a main aspect of current research in theoretical neuroscience. In this letter, the mechanisms of Spike Timing…

Neurons and Cognition · Quantitative Biology 2013-06-12 Mathieu Galtier , Gilles Wainrib

Brain plasticity refers to brain's ability to change neuronal connections, as a result of environmental stimuli, new experiences, or damage. In this work, we study the effects of the synaptic delay on both the coupling strengths and…

Neurons and Cognition · Quantitative Biology 2018-11-14 E. L. Lameu , E. E. N. Macau , F. S. Borges , K. C. Iarosz , I. L. Caldas , R. R. Borges , P. R. Protachevicz , R. L. Viana , A. M. Batista

Statistical properties of spike trains measured from a sensory neuron in-vivo are studied experimentally and theoretically. Experiments are performed on an identified neuron in the visual system of the blowfly. It is shown that the spike…

Biological Physics · Physics 2007-05-23 N. Brenner , O. Agam , W. Bialek , R. de Ruyter van Steveninck

Cortical networks can maintain memories for decades despite the short lifetime of synaptic strength. Can a neural network store long-lasting memories in unstable synapses? Here, we study the effects of random noise on the stability of…

Neurons and Cognition · Quantitative Biology 2012-06-01 Yi Wei , Alexei A. Koulakov

Neural circuits exhibit remarkable computational flexibility, enabling adaptive responses to noisy and ever-changing environmental cues. A fundamental question in neuroscience concerns how a wide range of behaviors can emerge from a…

Statistical Mechanics · Physics 2025-09-18 Giacomo Barzon , Daniel M. Busiello , Giorgio Nicoletti

We consider an excitatory population of subthreshold Izhikevich neurons which cannot fire spontaneously without noise. As the coupling strength passes a threshold, individual neurons exhibit noise-induced burstings. This neuronal population…

Neurons and Cognition · Quantitative Biology 2017-11-28 Sang-Yoon Kim , Woochang Lim

We introduce a mathematical framework where the statistics of spikes trains, produced by neural networks evolving under synaptic plasticity, can be analysed.

Adaptation and Self-Organizing Systems · Physics 2008-10-23 B. Cessac , H. Rostro , J. C. Vasquez , T. Viéville

A key question in neuroscience is at which level functional meaning emerges from biophysical phenomena. In most vertebrate systems, precise functions are assigned at the level of neural populations, while single-neurons are deemed…

Neurons and Cognition · Quantitative Biology 2017-03-17 Wieland Brendel , Ralph Bourdoukan , Pietro Vertechi , Christian K. Machens , Sophie Denéve

Cortical sensory neurons are known to be highly variable, in the sense that responses evoked by identical stimuli often change dramatically from trial to trial. The origin of this variability is uncertain, but it is usually interpreted as…

Neurons and Cognition · Quantitative Biology 2007-05-23 Gleb Basalyga , Emilio Salinas

In this work, we propose time-integrated spike-timing-dependent plasticity (TI-STDP), a mathematical model of synaptic plasticity that allows spiking neural networks to continuously adapt to sensory input streams in an unsupervised fashion.…

Neurons and Cognition · Quantitative Biology 2024-07-16 William Gebhardt , Alexander G. Ororbia

Humans perform remarkably well in many cognitive tasks including pattern recognition. However, the neuronal mechanisms underlying this process are not well understood. Nevertheless, artificial neural networks, inspired in brain circuits,…

Neurons and Cognition · Quantitative Biology 2018-06-28 Gianluca Susi , Luis Anton Toro , Leonides Canuet , Maria Eugenia Lopez , Fernando Maestu , Claudio R. Mirasso , Ernesto Pereda

General results from statistical learning theory suggest to understand not only brain computations, but also brain plasticity as probabilistic inference. But a model for that has been missing. We propose that inherently stochastic features…

Neural and Evolutionary Computing · Computer Science 2016-02-17 David Kappel , Stefan Habenschuss , Robert Legenstein , Wolfgang Maass

In the last century, most sensorimotor studies of cortical neurons relied on average firing rates. Rate coding is efficient for fast sensorimotor processing that occurs within a few seconds. Much less is known about the neural mechanisms…

Neurons and Cognition · Quantitative Biology 2026-05-01 Terrence J. Sejnowski

Spiking Neural Networks (SNNs), recognized for their biological plausibility and energy efficiency, employ sparse and asynchronous spikes for communication. However, the training of SNNs encounters difficulties coming from…

Neurons and Cognition · Quantitative Biology 2024-05-09 Sushant Yadav , Santosh Chaudhary , Rajesh Kumar

Recent studies have shown how spiking networks can learn complex functionality through error-correcting plasticity, but the resulting structures and dynamics remain poorly studied. To elucidate how these models may link to observed dynamics…

Neurons and Cognition · Quantitative Biology 2025-08-19 Jonas Oberste-Frielinghaus , Anno C. Kurth , Julian Göltz , Laura Kriener , Junji Ito , Mihai A. Petrovici , Sonja Grün

Understanding how the brain learns to compute functions reliably, efficiently and robustly with noisy spiking activity is a fundamental challenge in neuroscience. Most sensory and motor tasks can be described as dynamical systems and could…

Neurons and Cognition · Quantitative Biology 2017-05-24 Sophie Denève , Alireza Alemi , Ralph Bourdoukan
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