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To adapt their behaviour in changing environments, cells sense concentrations by binding external ligands to their receptors. However, incorrect ligands may bind nonspecifically to receptors, and when their concentration is large, this…

Molecular Networks · Quantitative Biology 2015-07-23 Thierry Mora

Cells respond to chemical cues, and the precision with which they can sense these cues is fundamentally limited by the stochastic nature of diffusion and ligand binding. Berg and Purcell famously investigated how well a small sensor in an…

Biological Physics · Physics 2025-03-21 Daniel R. McCusker , David K. Lubensky

A state-dependent discrete memoryless multiple access channel is considered to model an integrated sensing and communication system, where two transmitters wish to convey messages to a receiver while simultaneously estimating the state…

Information Theory · Computer Science 2025-06-19 Yao Liu , Min Li , An Liu , Lawrence Ong , Aylin Yener

Biological cells are able to accurately sense chemicals with receptors at their surfaces, allowing cells to move towards sources of attractant and away from sources of repellent. The accuracy of sensing chemical concentration is ultimately…

Subcellular Processes · Quantitative Biology 2015-05-14 Robert G. Endres , Ned S. Wingreen

Many types of cells can sense external ligand concentrations with cell-surface receptors at extremely high accuracy. Interestingly, ligand-bound receptors are often internalized, a process also known as receptor-mediated endocytosis. While…

Biological Physics · Physics 2015-05-18 Gerardo Aquino , Robert G. Endres

The problem of bistatic integrated sensing and communications over memoryless relay channels is considered, where destination concurrently decodes the message sent by the source and estimates unknown parameters from received signals with…

Information Theory · Computer Science 2026-03-05 Yao Liu , Min Li , Lawrence Ong , Aylin Yener

Large-scale distributed training requires significant communication bandwidth for gradient exchange that limits the scalability of multi-node training, and requires expensive high-bandwidth network infrastructure. The situation gets even…

Computer Vision and Pattern Recognition · Computer Science 2020-06-24 Yujun Lin , Song Han , Huizi Mao , Yu Wang , William J. Dally

The dependence of the diffusion MRI signal on the diffusion time carries signatures of restricted diffusion and exchange. Here we seek to highlight these signatures in the human brain by performing experiments using free gradient waveforms…

Inter and intra-cellular signaling are essential for individual cells to execute various physiological tasks and accurately respond to changes in their environment. Signaling is carried out via diffusible molecules, the transport of which…

Soft Condensed Matter · Physics 2020-10-13 Sumantra Sarkar , Sandeep Choubey

The scaling laws of the achievable communication rates and the corresponding upper bounds of distributed reception in the presence of an interfering signal are investigated. The scheme includes one transmitter communicating to a remote…

Information Theory · Computer Science 2009-12-08 Amichai Sanderovich , Michael Peleg , Shlomo Shamai

Cells need to reliably sense external ligand concentrations to achieve various biological functions such as chemotaxis or signaling. The molecular recognition of ligands by surface receptors is degenerate in many systems leading to…

One of the main focuses in distributed learning is communication efficiency, since model aggregation at each round of training can consist of millions to billions of parameters. Several model compression methods, such as gradient…

Information Theory · Computer Science 2022-06-29 Naifu Zhang , Meixia Tao , Jia Wang , Fan Xu

Distributed optimization increasingly plays a central role in economical and sustainable operation of cyber-physical systems. Nevertheless, the complete potential of the technology has not yet been fully exploited in practice due to…

Optimization and Control · Mathematics 2017-10-24 Sindri Magnusson , Chinwendu Enyioha , Na Li , Carlo Fischione , Vahid Tarokh

The physical limit with which a cell senses external ligand concentration corresponds to the perfect absorber, where all ligand particles are absorbed and overcounting of same ligand particles does not occur. Here we analyze how the lateral…

Subcellular Processes · Quantitative Biology 2015-11-06 Gerardo Aquino , Robert G. Endres

A diffusion-based molecular communication system has two major components: the diffusion in the medium, and the ligand-reception. Information bits, encoded in the time variations of the concentration of molecules, are conveyed to the…

Information Theory · Computer Science 2012-05-23 Arash Einolghozati , Mohsen Sardari , Faramarz Fekri

Distributed model training suffers from communication bottlenecks due to frequent model updates transmitted across compute nodes. To alleviate these bottlenecks, practitioners use gradient compression techniques like sparsification,…

Machine Learning · Computer Science 2020-11-02 Saurabh Agarwal , Hongyi Wang , Kangwook Lee , Shivaram Venkataraman , Dimitris Papailiopoulos

Information of relevance to the organism often is represented by the concentrations of particular molecules inside a cell. As outside observers we can now measure these concentrations precisely, but the cell's own mechanisms must be…

Biological Physics · Physics 2022-12-26 Marianne Bauer , William Bialek

The convergence of the Conjugate Gradient method is subject to a locality limitation which imposes a lower bound on the number of iterations required before a qualitatively accurate approximation can be obtained. This limitation originates…

Numerical Analysis · Mathematics 2026-01-16 Ulrich Rüde

Distributed deep learning has recently been attracting more attention in remote sensing (RS) applications due to the challenges posed by the increased amount of open data that are produced daily by Earth observation programs. However, the…

Computer Vision and Pattern Recognition · Computer Science 2024-01-01 Weiying Xie , Zixuan Wang , Jitao Ma , Daixun Li , Yunsong Li

We study information-theoretic security for discrete memoryless interference and broadcast channels with independent confidential messages sent to two receivers. Confidential messages are transmitted to their respective receivers with…

Information Theory · Computer Science 2016-11-15 Ruoheng Liu , Ivana Maric , Predrag Spasojevic , Roy D. Yates