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This paper demonstrates fundamental limits of sensor networks for detection problems where the number of hypotheses is exponentially large. Such problems characterize many important applications including detection and classification of…

Information Theory · Computer Science 2016-11-17 Yaron Rachlin , Rohit Negi , Pradeep Khosla

Gradient sensing underlies important biological processes including morphogenesis, polarization, and cell migration. The precision of gradient sensing increases with the length of a detector (a cell or group of cells) in the gradient…

Molecular Networks · Quantitative Biology 2016-06-22 Tyler Smith , Sean Fancher , Andre Levchenko , Ilya Nemenman , Andrew Mugler

Bistability is a major mechanism for cellular decision making and usually results from positive feedback in biochemical control systems. Here we show theoretically that bistability between unbound and bound states of adhesion clusters…

Subcellular Processes · Quantitative Biology 2010-02-24 T. Erdmann , U. S. Schwarz

A large number of eukaryotic cells are able to directly detect external chemical gradients with great accuracy and the ultimate limit to their sensitivity has been a topic of debate for many years. Previous work has been done to understand…

Cell Behavior · Quantitative Biology 2015-05-20 Stuart A. Sevier , Herbert Levine

Obtaining prescribed accuracy bounds in super-twisting sliding mode control loops often falls short in terms of the applicability of the controller in high-performance systems. This is due to the fact that the selection of the controller…

Systems and Control · Electrical Eng. & Systems 2022-06-29 Dimitrios Papageorgiou

Biological cells estimate concentration gradients of signaling molecules with a precision that is limited not only by sensing noise, but additionally by the cell's own stochastic motion. We ask for the theoretical limits of gradient…

Biological Physics · Physics 2021-05-26 Maja Novak , Benjamin M. Friedrich

Calibration refers to the estimation of unknown parameters which are present in computer experiments but not available in physical experiments. An accurate estimation of these parameters is important because it provides a scientific…

Methodology · Statistics 2019-03-21 Chih-Li Sung , Ying Hung , William Rittase , Cheng Zhu , C. F. Jeff Wu

It is well known that a minimum error quantum measurement for arbitrary binary optical coherent states can be realized by a receiver that comprises interfering with a coherent reference light, photon counting, and feedback control. We show…

Quantum Physics · Physics 2018-02-16 Kenji Nakahira , Kentaro Kato , Tsuyoshi Sasaki Usuda

Primate visual system samples different parts of the world unevenly. The part of the visual scene corresponding to the eye center is represented densely, while away from the center the sampling becomes progressively sparser. Such…

Neurons and Cognition · Quantitative Biology 2010-02-24 Alexei A. Koulakov

This paper gives a precise characterization of the fundamental limits of adaptive sensing for diverse estimation and testing problems concerning sparse signals. We consider in particular the setting introduced in (IEEE Trans. Inform. Theory…

Statistics Theory · Mathematics 2014-10-16 Rui M. Castro

Physiologic signals have properties across multiple spatial and temporal scales, which can be shown by the complexity-analysis of the coarse-grained physiologic signals by scaling techniques such as the multiscale. Unfortunately, the…

Machine Learning · Computer Science 2020-11-10 Jiawei Yang , Jeffrey M. Hausdorff

Transformer models have achieved remarkable results in a wide range of applications. However, their scalability is hampered by the quadratic time and memory complexity of the self-attention mechanism concerning the sequence length. This…

Machine Learning · Computer Science 2024-02-27 Yury Nahshan , Joseph Kampeas , Emir Haleva

In its vast majority entanglement verification is examined either in the complete characterized or totally device independent scenario. The assumptions imposed by these extreme cases are often either too weak or strong for real experiments.…

Quantum Physics · Physics 2013-05-30 Tobias Moroder , Oleg Gittsovich

In this paper, we apply dimensional analysis to study a diffusive molecular communication system that uses diffusing enzymes in the propagation environment to mitigate intersymbol interference. The enzymes bind to information molecules and…

Information Theory · Computer Science 2013-11-21 Adam Noel , Karen C. Cheung , Robert Schober

The dynamics of a system interacting with an ultrashort pulse is known to depend on the phase content of said pulse. For linear absorption, phase control is possible over time-varying quantities, such as the population of metastable states,…

Chemical Physics · Physics 2019-10-31 Cyrille Lavigne , Paul Brumer

Biomolecular condensates form on timescales of seconds in cells upon environmental or compositional changes. Condensate formation is thus argued to act as a mechanism for sensing such changes and quickly initiating downstream processes,…

Subcellular Processes · Quantitative Biology 2025-12-09 Henry Alston , Mason Rouches , Arvind Murugan , Aleksandra M. Walczak , Thierry Mora

We consider a set of primary channels that operate in an unslotted fashion, switching activity at random times. A secondary user senses the primary channels searching for transmission opportunities. If a channel is sensed to be free, the…

Networking and Internet Architecture · Computer Science 2010-07-08 Omar Mehanna , Ahmed Sultan

Additional sensitivities to Lorentz violation can be obtained from existing experiments by considering additional boost-suppressed effects. The additional Lorentz-violating signals arise as variations in experimental observables at the…

High Energy Physics - Phenomenology · Physics 2025-12-22 Jay D. Tasson

Many types of cells are able to accurately sense shallow gradients of chemicals across their diameters, allowing the cells to move towards or away from chemical sources. This chemotactic ability relies on the remarkable capacity of cells to…

Cell Behavior · Quantitative Biology 2015-05-13 Robert G. Endres , Ned S. Wingreen

Protein binding often involves conformational changes. Important questions are whether a conformational change occurs prior to a binding event ('conformational selection') or after a binding event ('induced fit'), and how conformational…

Biomolecules · Quantitative Biology 2016-09-22 Fabian Paul , Thomas R. Weikl