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Single particle cryogenic electron microscopy (cryo-EM) is an imaging technique capable of recovering the high-resolution 3-D structure of biological macromolecules from many noisy and randomly oriented projection images. One notable…

Biomolecules · Quantitative Biology 2024-01-30 Andy Zhang , Oscar Mickelin , Joe Kileel , Eric J. Verbeke , Nicholas F. Marshall , Marc Aurèle Gilles , Amit Singer

This work reports on a new reconstruction algorithm allowing to reconstruct the decays of ortho-positronium atoms into three photons using the places and times of photons recorded in the detector. The method is based on trilateration and…

Positron Emission Tomography (PET) is a powerful molecular imaging tool that plays a crucial role in modern medical diagnostics by visualizing radio-tracer distribution to reveal physiological processes. Accurate organ segmentation from PET…

Computer Vision and Pattern Recognition · Computer Science 2026-03-13 Yichi Zhang , Le Xue , Wenbo Zhang , Lanlan Li , Yuchen Liu , Chen Jiang , Yuan Cheng , Yuan Qi

Improving the quality of positron emission tomography (PET) images, affected by low resolution and high level of noise, is a challenging task in nuclear medicine and radiotherapy. This work proposes a restoration method, achieved after…

Computer Vision and Pattern Recognition · Computer Science 2015-06-17 Stéphanie Guérit , Laurent Jacques , Benoît Macq , John A. Lee

Modern electron tomography has progressed to higher resolution at lower doses by leveraging compressed sensing methods that minimize total variation (TV). However, these sparsity-emphasized reconstruction algorithms introduce tunable…

Medical Physics · Physics 2023-09-12 William Millsaps , Jonathan Schwartz , Zichao Wendy Di , Yi Jiang , Robert Hovden

Positron emission tomography, like many other tomographic imaging modalities, relies on an image reconstruction step to produce cross-sectional images from projection data. Detection and localization of the back-to-back annihilation photons…

In positron emission tomography acquisition (PET), sensitivity along a line of response can vary due to crystal geometrical arrangements in the scanner and/or detector inefficiencies, leading to severe artefacts in the reconstructed image.…

Positron emission tomography (PET) imaging is widely used in a number of clinical applications, including cancer and Alzheimer's disease (AD) diagnosis, monitoring of disease development, and treatment effect evaluation. Statistical…

Tissues and Organs · Quantitative Biology 2025-11-07 Akhil Ambekar , Robert Zielinski , Ani Eloyan

Computed Tomography (CT) reconstruction of objects with cylindrical symmetry can be performed with a single projection. When the measured rays are parallel, and the axis of symmetry is perpendicular to the optical axis, the data can be…

Medical Physics · Physics 2024-10-15 Kyle M. Champley , Ibrahim Oksuz , Matthew G. Bisbee , Joseph W. Tringe , Brian Maddox

Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET) automatic 3-D registration is implemented and validated for small animal image volumes so that the high-resolution anatomical MRI information can be fused with the low…

Computer Vision and Pattern Recognition · Computer Science 2017-05-24 Nathanael L. Baisa , Stéphanie Bricq , Alain Lalande

To obtain high-quality Positron emission tomography (PET) images while minimizing radiation exposure, numerous methods have been proposed to reconstruct standard-dose PET (SPET) images from the corresponding low-dose PET (LPET) images.…

Image and Video Processing · Electrical Eng. & Systems 2024-04-10 Jiaqi Cui , Yan Wang , Lu Wen , Pinxian Zeng , Xi Wu , Jiliu Zhou , Dinggang Shen

Positron emission tomography (PET) reconstruction has become an ill-posed inverse problem due to low-count projection data, and a robust algorithm is urgently required to improve imaging quality. Recently, the deep image prior (DIP) has…

Image and Video Processing · Electrical Eng. & Systems 2021-11-01 Chenyu Shen , Wenjun Xia , Hongwei Ye , Mingzheng Hou , Hu Chen , Yan Liu , Jiliu Zhou , Yi Zhang

Photoemission orbital tomography provides direct access from laboratory measurements to the real-space molecular orbitals of well-ordered organic semiconductor layers. Specifically, the application of phase retrieval algorithms to…

Materials Science · Physics 2024-04-29 Thi Lan Dinh , G. S. Matthijs Jansen , D. Russell Luke , Wiebke Bennecke , Stefan Mathias

Computed tomography (CT) provides high spatial resolution visualization of 3D structures for scientific and clinical applications. Traditional analytical/iterative CT reconstruction algorithms require hundreds of angular data samplings, a…

Image and Video Processing · Electrical Eng. & Systems 2024-11-14 Di Xu , Yang Yang , Hengjie Liu , Qihui Lyu , Martina Descovich , Dan Ruan , Ke Sheng

Images from positron emission tomography (PET) provide metabolic information about the human body. They present, however, a spatial resolution that is limited by physical and instrumental factors often modeled by a blurring function. Since…

Computer Vision and Pattern Recognition · Computer Science 2016-08-08 Stéphanie Guérit , Adriana González , Anne Bol , John A. Lee , Laurent Jacques

Artificial intelligence (AI) is entering medical imaging, mainly enhancing image reconstruction. Nevertheless, improvements throughout the entire processing, from signal detection to computation, potentially offer significant benefits. This…

Machine Learning · Computer Science 2023-10-27 Stephan Naunheim , Yannick Kuhl , David Schug , Volkmar Schulz , Florian Mueller

Dual-energy computed tomography (DECT) has shown great potential and promising applications in advanced imaging fields for its capabilities of material decomposition. However, image reconstructions and decompositions under sparse views…

Medical Physics · Physics 2016-08-01 Lei Li , Ailong Cai , Linyuan Wang , Bin Yan , Hanming Zhang , Zhizhong Zheng , Wenkun Zhang , Wanli Lu , Guoen Hu

Positron emission tomography/computed tomography (PET/CT) is essential in oncology, yet the rapid expansion of scanners has outpaced the availability of trained specialists, making automated PET/CT report generation (PETRG) increasingly…

Computer Vision and Pattern Recognition · Computer Science 2025-11-26 Wenpei Jiao , Kun Shang , Hui Li , Ke Yan , Jiajin Zhang , Guangjie Yang , Lijuan Guo , Yan Wan , Xing Yang , Dakai Jin , Zhaoheng Xie

Computed tomography (CT) reconstructs volumetric images using X-ray projection data acquired from multiple angles around an object. For low-dose or sparse-view CT scans, the classic image reconstruction algorithms often produce severe noise…

Medical Physics · Physics 2024-03-04 Wenxiang Cong , Wenjun Xia , Ge Wang

Training computer-vision related algorithms on medical images for disease diagnosis or image segmentation is difficult due to the lack of training data, labeled samples, and privacy concerns. For this reason, a robust generative method to…

Image and Video Processing · Electrical Eng. & Systems 2021-11-04 Robert V Bergen , Jean-Francois Rajotte , Fereshteh Yousefirizi , Ivan S Klyuzhin , Arman Rahmim , Raymond T. Ng