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Genome assembly using high throughput data with short reads, arguably, remains an unresolvable task in repetitive genomes, since when the length of a repeat exceeds the read length, it becomes difficult to unambiguously connect the flanking…

Quantitative Methods · Quantitative Biology 2013-07-31 Viraj Deshpande , Eric DK Fung , Son Pham , Vineet Bafna

The de novo assembly of large, complex genomes is a significant challenge with currently available DNA sequencing technology. While many de novo assembly software packages are available, comparatively little attention has been paid to…

Genomics · Quantitative Biology 2013-07-31 Jared T. Simpson

The study of genetic map linearization leads to a combinatorial hard problem, called the {\em minimum breakpoint linearization} (MBL) problem. It is aimed at finding a linearization of a partial order which attains the minimum breakpoint…

Genomics · Quantitative Biology 2015-02-26 Xin Chen

Large language models (LLMs), typically designed as a function of next-word prediction, have excelled across extensive NLP tasks. Despite the generality, next-word prediction is often not an efficient formulation for many of the tasks,…

Computation and Language · Computer Science 2023-11-03 Yuheng Zha , Yichi Yang , Ruichen Li , Zhiting Hu

Large language models (LLMs) can often generate functionally correct code, but their ability to produce efficient implementations for performance-critical systems tasks remains limited. Existing code benchmarks mainly emphasize correctness…

Software Engineering · Computer Science 2026-05-18 Huihao Jing , Wenbin Hu , Haochen Shi , Hanyu Yang , Sirui Zhang , Shaojin Chen , Haoran Li , Yangqiu Song

As large language models (LLMs) become integral to code-related tasks, a central question emerges: Do LLMs truly understand program semantics? We introduce EquiBench, a new benchmark for evaluating LLMs through equivalence checking, i.e.,…

Machine Learning · Computer Science 2025-09-23 Anjiang Wei , Jiannan Cao , Ran Li , Hongyu Chen , Yuhui Zhang , Ziheng Wang , Yuan Liu , Thiago S. F. X. Teixeira , Diyi Yang , Ke Wang , Alex Aiken

Summary: With the rapid development of long-read sequencing technologies, the era of individual complete genomes is approaching. We have developed wgatools, a cross-platform, ultrafast toolkit that supports a range of whole genome alignment…

Genomics · Quantitative Biology 2025-04-01 Wenjie Wei , Songtao Gui , Jian Yang , Erik Garrison , Jianbing Yan , Hai-Jun Liu

This paper introduces a high-throughput software tool framework called {\it sam2bam} that enables users to significantly speedup pre-processing for next-generation sequencing data. The sam2bam is especially efficient on single-node…

Genomics · Quantitative Biology 2017-02-08 Takeshi Ogasawara , Yinhe Cheng , Tzy-Hwa Kathy Tzeng

Recent advances in probabilistic modelling have led to a large number of simulation-based inference algorithms which do not require numerical evaluation of likelihoods. However, a public benchmark with appropriate performance metrics for…

Machine Learning · Statistics 2021-04-12 Jan-Matthis Lueckmann , Jan Boelts , David S. Greenberg , Pedro J. Gonçalves , Jakob H. Macke

Text alignment finds application in tasks such as citation recommendation and plagiarism detection. Existing alignment methods operate at a single, predefined level and cannot learn to align texts at, for example, sentence and document…

Computation and Language · Computer Science 2020-10-06 Xuhui Zhou , Nikolaos Pappas , Noah A. Smith

Genome sequence analysis is a powerful tool in medical and scientific research. Considering the inevitable sequencing errors and genetic variations, approximate string matching (ASM) has been adopted in practice for genome sequencing.…

We propose a metric for the space of multiple sequence alignments that can be used to compare two alignments to each other. In the case where one of the alignments is a reference alignment, the resulting accuracy measure improves upon…

Quantitative Methods · Quantitative Biology 2011-11-09 Ariel S. Schwartz , Eugene W. Myers , Lior Pachter

The increasing attention on deep learning has tremendously spurred the design of intelligence processing hardware. The variety of emerging intelligence processors requires standard benchmarks for fair comparison and system optimization (in…

Automated interlinear gloss prediction with neural networks is a promising approach to accelerate language documentation efforts. However, while state-of-the-art models like GlossLM achieve high scores on glossing benchmarks, user studies…

Computation and Language · Computer Science 2026-01-26 Michael Ginn , Lindia Tjuatja , Enora Rice , Ali Marashian , Maria Valentini , Jasmine Xu , Graham Neubig , Alexis Palmer

Prokaryotic gene prediction plays an important role in understanding the biology of organisms and their function with applications in medicine and biotechnology. Although the current gene finders are highly sensitive in finding long genes,…

Genomics · Quantitative Biology 2023-07-21 Tony Tu , Gautham Krishna , Amirali Aghazadeh

With the advance in genome sequencing technology, the lengths of deoxyribonucleic acid (DNA) sequencing results are rapidly increasing at lower prices than ever. However, the longer lengths come at the cost of a heavy computational burden…

Distributed, Parallel, and Cluster Computing · Computer Science 2024-03-12 Seongyeon Park , Junguk Hong , Jaeyong Song , Hajin Kim , Youngsok Kim , Jinho Lee

Beam alignment - the process of finding an optimal directional beam pair - is a challenging procedure crucial to millimeter wave (mmWave) communication systems. We propose a novel beam alignment method that learns a site-specific probing…

Signal Processing · Electrical Eng. & Systems 2021-07-29 Yuqiang Heng , Jianhua Mo , Jeffrey G. Andrews

The field of cross-lingual sentence embeddings has recently experienced significant advancements, but research concerning low-resource languages has lagged due to the scarcity of parallel corpora. This paper shows that cross-lingual word…

Computation and Language · Computer Science 2024-04-04 Zhongtao Miao , Qiyu Wu , Kaiyan Zhao , Zilong Wu , Yoshimasa Tsuruoka

Sequence alignment is common nowadays as it is used in many fields to determine how closely two sequences are related and at times to see how little they differ. In computational biology / Bioinformatics, there are many algorithms developed…

Information Theory · Computer Science 2023-05-02 Bharath Reddy , Richard Fields

This paper describes a suite of algorithms for constructing low-rank approximations of an input matrix from a random linear image of the matrix, called a sketch. These methods can preserve structural properties of the input matrix, such as…

Numerical Analysis · Computer Science 2018-01-03 Joel A. Tropp , Alp Yurtsever , Madeleine Udell , Volkan Cevher