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Next-generation sequencing technologies generate millions of short sequence reads, which are usually aligned to a reference genome. In many applications, the key information required for downstream analysis is the number of reads mapping to…

Genomics · Quantitative Biology 2016-07-26 Yang Liao , Gordon K Smyth , Wei Shi

In-memory computing (IMC) with single instruction multiple data (SIMD) setup enables memory to perform operations on the stored data in parallel to achieve high throughput and energy saving. To instruct a SIMD IMC hardware to compute a…

Emerging Technologies · Computer Science 2024-12-04 Xingyue Qian , Chenyang Lv , Zhezhi He , Weikang Qian

Frequent Subgraph Mining (FSM) is the process of identifying common subgraph patterns that surpass a predefined frequency threshold. While FSM is widely applicable in fields like bioinformatics, chemical analysis, and social network anomaly…

Databases · Computer Science 2024-04-03 Akshit Sharma , Sam Reinher , Dinesh Mehta , Bo Wu

Frequent itemset mining (FIM) is a highly computational and data intensive algorithm. Therefore, parallel and distributed FIM algorithms have been designed to process large volume of data in a reduced time. Recently, a number of FIM…

Distributed, Parallel, and Cluster Computing · Computer Science 2021-10-26 Pankaj Singh , Sudhakar Singh , P K Mishra , Rakhi Garg

Background: Haplotypes, the ordered lists of single nucleotide variations that distinguish chromosomal sequences from their homologous pairs, may reveal an individual's susceptibility to hereditary and complex diseases and affect how our…

Social and Information Networks · Computer Science 2019-11-28 Abishek Sankararaman , Haris Vikalo , François Baccelli

Developing kernels for Processing-In-Memory (PIM) platforms poses unique challenges in data management and parallel programming on limited processing units. Although software development kits (SDKs) for PIM, such as the UPMEM SDK, provide…

Hardware Architecture · Computer Science 2025-10-21 Krystian Chmielewski , Jarosław Ławnicki , Uladzislau Lukyanau , Tadeusz Kobus , Maciej Maciejewski

Fermipy is an open-source python framework that facilitates analysis of data collected by the Fermi Large Area Telescope (LAT). Fermipy is built on the Fermi Science Tools, the publicly available software suite provided by NASA for the LAT…

Instrumentation and Methods for Astrophysics · Physics 2019-08-14 Matthew Wood , Regina Caputo , Eric Charles , Mattia Di Mauro , Jeffrey Magill , Jeremy Perkins

On-chip analog Ising Machines (IMs) are a promising means to solve difficult combinatorial optimization problems. For scalable on-chip realizations to be practical, 1) the problem should map scalably to Ising form, 2) interconnectivity…

Emerging Technologies · Computer Science 2023-10-03 Thomas Jagielski , Rajit Manohar , Jaijeet Roychowdhury

Aligning millions of short DNA or RNA reads, of 75 to 250 base pairs each, to a reference genome is a significant computation problem in bioinformatics. We present a flexible and fast FPGA-based short read alignment tool. Our aligner makes…

Genomics · Quantitative Biology 2018-05-02 Nathaniel McVicar , Akina Hoshino , Anna La Torre , Thomas A. Reh , Walter L. Ruzzo , Scott Hauck

Gamma rays measured by the Fermi-LAT satellite tell us a lot about the processes taking place in high-energetic astrophysical objects. The fluxes coming from these objects are, however, extremely variable. Hence, gamma-ray light curves…

Instrumentation and Methods for Astrophysics · Physics 2025-02-13 Theo Glauch , Kristian Tchiorniy

Many web databases can be seen as providing partial and overlapping information about entities in the world. To answer queries effectively, we need to integrate the information about the individual entities that are fragmented over multiple…

Databases · Computer Science 2011-02-01 Ravi Gummadi , Anupam Khulbe , Aravind Kalavagattu , Sanil Salvi , Subbarao Kambhampati

Phenotyping consists in applying algorithms to identify individuals associated with a specific, potentially complex, trait or condition, typically out of a collection of Electronic Health Records (EHRs). Because a lot of the clinical…

The Scripted E-merlin Rfi-mitigation PipelinE for iNTerferometry (SERPent) is an automated reduction and RFI-mitigation procedure utilising the SumThreshold methodology (Offringa et al. 2010b), originally developed for the LOFAR pipeline.…

Instrumentation and Methods for Astrophysics · Physics 2014-02-03 Luke Peck , Danielle Fenech

Although feature models are widely used in practice, for example, representing variability in software product lines, their integration is still a challenge. Many integration techniques have been proposed, although none of these have proven…

Software Engineering · Computer Science 2018-10-01 Vinicius Bischoff

The emergence of Large Language Models (LLMs) with capabilities like In-Context Learning (ICL) has ushered in new possibilities for data generation across various domains while minimizing the need for extensive data collection and modeling…

Computation and Language · Computer Science 2024-04-16 Amani Namboori , Shivam Mangale , Andy Rosenbaum , Saleh Soltan

With the advent of large language models (LLMs) and multimodal large language models (MLLMs), the potential of retrieval-augmented generation (RAG) has attracted considerable research attention. Various novel algorithms and models have been…

Computation and Language · Computer Science 2025-02-25 Jiajie Jin , Yutao Zhu , Guanting Dong , Yuyao Zhang , Xinyu Yang , Chenghao Zhang , Tong Zhao , Zhao Yang , Zhicheng Dou , Ji-Rong Wen

Labelling data is expensive and time consuming especially for domains such as medical imaging that contain volumetric imaging data and require expert knowledge. Exploiting a larger pool of labeled data available across multiple centers,…

Computer Vision and Pattern Recognition · Computer Science 2020-09-03 Daiqing Li , Amlan Kar , Nishant Ravikumar , Alejandro F Frangi , Sanja Fidler

Efficient inference of LLMs remains a crucial challenge, with two main phases: a compute-intensive prompt computation and a memory-intensive token generation. Despite existing batching and scheduling techniques, token generation phases fail…

Hardware Architecture · Computer Science 2025-05-08 Asad Aali , Adney Cardoza , Melissa Capo

We present a new algorithm, Fractional Decomposition Tree (FDT) for finding a feasible solution for an integer program (IP) where all variables are binary. FDT runs in polynomial time and is guaranteed to find a feasible integer solution…

Discrete Mathematics · Computer Science 2020-08-12 Robert D. Carr , Arash Haddadan , Cynthia A. Phillips

The vision transformer splits each image into a sequence of tokens with fixed length and processes the tokens in the same way as words in natural language processing. More tokens normally lead to better performance but considerably…

Computer Vision and Pattern Recognition · Computer Science 2021-12-07 Yichen Zhu , Yuqin Zhu , Jie Du , Yi Wang , Zhicai Ou , Feifei Feng , Jian Tang