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Four-dimensional MRI (4D-MRI) is an promising technique for capturing respiratory-induced motion in radiation therapy planning and delivery. Conventional 4D reconstruction methods, which typically rely on phase binning or separate template…

Computer Vision and Pattern Recognition · Computer Science 2025-09-24 Xinyang Wu , Muheng Li , Xia Li , Orso Pusterla , Sairos Safai , Philippe C. Cattin , Antony J. Lomax , Ye Zhang

A central problem in the field of radiation therapy (RT) is how to optimally deliver dose to a patient in a way that fully accounts for anatomical position changes over time. As current RT is a static process, where beam intensities are…

Medical Physics · Physics 2019-09-04 Rodney D. Wiersma , Xinmin Liu

We present a novel algorithm for the registration of pulmonary CT scans. Our method is designed for large respiratory motion by integrating sparse keypoint correspondences into a dense continuous optimization framework. The detection of…

Computer Vision and Pattern Recognition · Computer Science 2018-07-03 Jan Rühaak , Thomas Polzin , Stefan Heldmann , Ivor J. A. Simpson , Heinz Handels , Jan Modersitzki , Mattias P. Heinrich

Stereotactic Arrhythmia Radiotherapy (STAR) treats ventricular tachycardia (VT) but requires internal target volume (ITV) expansions to compensate for cardiorespiratory motion. Current clinical r4DCT imaging methods are limited, and the…

Medical Physics · Physics 2025-11-24 Yuhao Wang , Yao Hao , Hongyu An , H Michael Gach , Clifford Robinson , Phillip S Cuculich , Deshan Yang

Purpose: To evaluate reliability of upright CT for proton dose calculation and feasibility of a simplified phantom configuration for accelerated routine QA. Methods: A calibration phantom was scanned on an upright CT following consensus…

The purpose of this study is to correct the movement errors that may occur because of the patients' movement during the CT scanning and thus, to obtain more precise CT images, additionally to investigate the possible use of Parallel Beam CT…

Medical Physics · Physics 2020-05-08 Seokhwan Yoon , Seong-Kyun Kim , Kyungtaek Jun

Contouring of the target volume and Organs-At-Risk (OARs) is a crucial step in radiotherapy treatment planning. In an adaptive radiotherapy setting, updated contours need to be generated based on daily imaging. In this work, we leverage…

Image and Video Processing · Electrical Eng. & Systems 2020-02-19 Mohamed S. Elmahdy , Tanuj Ahuja , U. A. van der Heide , Marius Staring

Cone-beam computed tomography (CBCT) is an imaging modality widely used in head and neck diagnostics due to its accessibility and lower radiation dose. However, its relatively long acquisition times make it susceptible to patient motion,…

Radiotherapy often involves a prolonged treatment period. During this time, patients may experience organ motion due to breathing and other physiological factors. Predicting and modeling this motion before treatment is crucial for ensuring…

Image and Video Processing · Electrical Eng. & Systems 2025-05-20 Yuxiang Lai , Jike Zhong , Vanessa Su , Xiaofeng Yang

Purpose: Organ-at-risk (OAR) delineation is a key step for cone-beam CT (CBCT) based adaptive radiotherapy planning that can be a time-consuming, labor-intensive, and subject-to-variability process. We aim to develop a fully automated…

Radiotherapy (RT) is a critical cancer treatment, with volumetric modulated arc therapy (VMAT) being a commonly used technique that enhances dose conformity by dynamically adjusting multileaf collimator (MLC) positions and monitor units…

Medical Physics · Physics 2025-06-26 Stefanos Achlatis , Efstratios Gavves , Jan-Jakob Sonke

An MRI-only adaptive radiotherapy (ART) workflow is desirable for managing interfractional changes in anatomy, but producing synthetic CT (sCT) data through paired data-driven deep learning (DL) for abdominal dose calculations remains a…

We present a new imaging system to support real-time tumor tracking for surface-guided radiotherapy (SGRT). SGRT uses optical surface imaging (OSI) to acquire real-time surface topography images of the patient on the treatment couch.…

Medical Physics · Physics 2024-11-04 Shaoyan Pan , Vanessa Su , Junbo Peng , Junyuan Li , Yuan Gao , Chih-Wei Chang , Tonghe Wang , Zhen Tian , Xiaofeng Yang

Adaptive radiation therapy (ART) could protect organs at risk (OARs) while maintain high dose coverage to targets. However, there still lack efficient online patient QA methods. We aim to develop a clinically relevant online patient quality…

A spring-dashpot system based on the Voigt model was developed to model the correlation between abdominal respiratory motion and tumor motion during lung radiotherapy. The model was applied to clinical data comprising 52 treatment beams…

Medical Physics · Physics 2020-06-05 E. J. Ackerley , A. E. Cavan , P. L. Wilson , R. I. Berbeco , J. Meyer

Accurate delineation of pancreatic tumors is critical for diagnosis, treatment planning, and outcome assessment, yet automated segmentation remains challenging due to anatomical variability and limited dataset availability. In this study,…

Computer Vision and Pattern Recognition · Computer Science 2025-09-01 Keshav Jha , William Sharp , Dominic LaBella

Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer in which the tumor-vascular involvement greatly affects the resectability and, thus, overall survival of patients. However, current prognostic prediction methods fail to…

Image and Video Processing · Electrical Eng. & Systems 2023-09-14 Hexin Dong , Jiawen Yao , Yuxing Tang , Mingze Yuan , Yingda Xia , Jian Zhou , Hong Lu , Jingren Zhou , Bin Dong , Le Lu , Li Zhang , Zaiyi Liu , Yu Shi , Ling Zhang

Background: Cardiac resynchronization therapy (CRT) has emerged as an effective treatment for heart failure patients with electrical dyssynchrony. However, accurately predicting which patients will respond to CRT remains a challenge. This…

Signal Processing · Electrical Eng. & Systems 2023-06-05 Zhuo He , Hongjin Si , Xinwei Zhang , Qing-Hui Chen , Jiangang Zou , Weihua Zhou

Introduction: This study uses KV CBCT based Synthetic CT (sCT) generated through Velocity workstation and compare the target and normal tissue doses with Adaptive plan CT doses. Methods: Thirty head and neck cancer patients undergoing…

Cone-beam computed tomography (CBCT) systems, with their flexibility, present a promising avenue for direct point-of-care medical imaging, particularly in critical scenarios such as acute stroke assessment. However, the integration of CBCT…