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The hippocampus supports spatial navigation by encoding cognitive maps through collective place cell activity. We model the place cell population as non-negative spatial embeddings derived from the spectral decomposition of multi-step…

Neurons and Cognition · Quantitative Biology 2025-10-28 Minglu Zhao , Dehong Xu , Deqian Kong , Wen-Hao Zhang , Ying Nian Wu

Probabilistic graphical models (PGMs) have become a popular tool for computational analysis of biological data in a variety of domains. But, what exactly are they and how do they work? How can we use PGMs to discover patterns that are…

Quantitative Methods · Quantitative Biology 2010-02-22 Edoardo M Airoldi

Microscopic analysis of histological sections is considered the "gold standard" to verify structural parcellations in the human brain. Its high resolution allows the study of laminar and columnar patterns of cell distributions, which build…

Computer Vision and Pattern Recognition · Computer Science 2017-08-01 Hannah Spitzer , Katrin Amunts , Stefan Harmeling , Timo Dickscheid

Hippocampal cognitive map---a neuronal representation of the spatial environment---is broadly discussed in the computational neuroscience literature for decades. More recent studies point out that hippocampus plays a major role in producing…

Neurons and Cognition · Quantitative Biology 2017-10-18 Andrey Babichev , Yuri Dabaghian

Noninvasive brain computer interfaces (BCI), and more specifically Electroencephalography (EEG) based systems for intent detection need to compensate for the low signal to noise ratio of EEG signals. In many applications, the temporal…

Human-Computer Interaction · Computer Science 2017-03-09 Seyed Sadegh Mohseni Salehi , Mohammad Moghadamfalahi , Hooman Nezamfar , Marzieh Haghighi , Deniz Erdogmus

Living systems exhibit complex yet organized behavior on multiple spatiotemporal scales. To investigate the nature of multiscale coordination in living systems, one needs a meaningful and systematic way to quantify the complex dynamics, a…

Adaptation and Self-Organizing Systems · Physics 2020-03-11 Mengsen Zhang , William D. Kalies , J. A. Scott Kelso , Emmanuelle Tognoli

One of the central tasks in many-body physics is the determination of phase diagrams. However, mapping out a phase diagram generally requires a great deal of human intuition and understanding. To automate this process, one can frame it as a…

Quantum Physics · Physics 2024-05-20 Julian Arnold , Frank Schäfer , Alan Edelman , Christoph Bruder

Autonomous agents rely on sensor data to construct representations of their environments, essential for predicting future events and planning their actions. However, sensor measurements suffer from limited range, occlusions, and sensor…

Being permanently confronted with an uncertain world, brains have faced evolutionary pressure to represent this uncertainty in order to respond appropriately. Often, this requires visiting multiple interpretations of the available…

We present a means of formulating and solving the well known structure-and-motion problem in computer vision with probabilistic graphical models. We model the unknown camera poses and 3D feature coordinates as well as the observed 2D…

Computer Vision and Pattern Recognition · Computer Science 2021-10-11 Simon Streicher , Willie Brink , Johan du Preez

We explore the probabilistic foundations of shared control in complex dynamic environments. In order to do this, we formulate shared control as a random process and describe the joint distribution that governs its behavior. For…

Robotics · Computer Science 2015-08-10 Pete Trautman

In this paper we focus on spatial Markov population models, describing the stochastic evolution of populations of agents, explicitly modelling their spatial distribution, representing space as a discrete, finite graph. More specifically, we…

Multiagent Systems · Computer Science 2016-10-27 Luca Bortolussi , Cheng Feng

The brain as an astonishingly remarkable device has been studied from various angles. It is now well known that neurons are the seat of all activities of the brain function. The dynamical properties pertaining to a single neuron and a…

Neurons and Cognition · Quantitative Biology 2007-05-23 I. Mitra

A model of sensory information processing is presented. The model assumes that learning of internal (hidden) generative models, which can predict the future and evaluate the precision of that prediction, is of central importance for…

Neural and Evolutionary Computing · Computer Science 2007-05-23 Andras Lorincz

A generative model is developed for deep (multi-layered) convolutional dictionary learning. A novel probabilistic pooling operation is integrated into the deep model, yielding efficient bottom-up (pretraining) and top-down (refinement)…

Machine Learning · Statistics 2015-04-17 Yunchen Pu , Xin Yuan , Lawrence Carin

Graphical model learning and inference are often performed using Bayesian techniques. In particular, learning is usually performed in two separate steps. First, the graph structure is learned from the data; then the parameters of the model…

Statistics Theory · Mathematics 2013-09-09 Marco Scutari

In digital pathology, the spatial context of cells is important for cell classification, cancer diagnosis and prognosis. To model such complex cell context, however, is challenging. Cells form different mixtures, lineages, clusters and…

Image and Video Processing · Electrical Eng. & Systems 2023-04-06 Shahira Abousamra , Rajarsi Gupta , Tahsin Kurc , Dimitris Samaras , Joel Saltz , Chao Chen

Cells regulate themselves via dizzyingly complex biochemical processes called signaling pathways. These are usually depicted as a network, where nodes represent proteins and edges indicate their influence on each other. In order to…

Molecular Networks · Quantitative Biology 2021-01-13 David Merrell , Anthony Gitter

Computational modeling helps neuroscientists to integrate and explain experimental data obtained through neurophysiological and anatomical studies, thus providing a mechanism by which we can better understand and predict the principles of…

Neurons and Cognition · Quantitative Biology 2023-09-22 Parvin Zarei Eskikand , David B Grayden , Tatiana Kameneva , Anthony N Burkitt , Michael R Ibbotson

Generative models such as diffusion models, excel at capturing high-dimensional distributions with diverse input modalities, e.g. robot trajectories, but are less effective at multi-step constraint reasoning. Task and Motion Planning (TAMP)…

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