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Genetic information is encoded in a linear sequence of nucleotides, represented by letters ranging from thousands to billions. Mutations refer to changes in the DNA or RNA nucleotide sequence. Thus, mutation detection is vital in all areas…

As applications of generative AI become mainstream, it is important to understand what generative models are capable of producing, and the extent to which one can predictably control their outputs. In this paper, we propose a visualization…

Human-Computer Interaction · Computer Science 2024-07-01 Sangwon Jeong , Mingwei Li , Matthew Berger , Shusen Liu

Transcriptional profiling on microarrays to obtain gene expressions has been used to facilitate cancer diagnosis. We propose a deep generative machine learning architecture (called DeepCancer) that learn features from unlabeled microarray…

Artificial Intelligence · Computer Science 2016-12-14 Rajendra Rana Bhat , Vivek Viswanath , Xiaolin Li

Scientific publications have evolved several features for mitigating vocabulary mismatch when indexing, retrieving, and computing similarity between articles. These mitigation strategies range from simply focusing on high-value article…

Machine Learning · Statistics 2017-12-20 Kriste Krstovski , Michael J. Kurtz , David A. Smith , Alberto Accomazzi

This work aims to evaluate the ability that both probabilistic and state-of-the-art vector space modeling (VSM) methods provide to well known machine learning algorithms to identify social network documents to be classified as aggressive,…

Designing face recognition systems that are capable of matching face images obtained in the thermal spectrum with those obtained in the visible spectrum is a challenging problem. In this work, we propose the use of semantic-guided…

Computer Vision and Pattern Recognition · Computer Science 2019-03-05 Cunjian Chen , Arun Ross

Textual-visual matching aims at measuring similarities between sentence descriptions and images. Most existing methods tackle this problem without effectively utilizing identity-level annotations. In this paper, we propose an identity-aware…

Computer Vision and Pattern Recognition · Computer Science 2017-08-08 Shuang Li , Tong Xiao , Hongsheng Li , Wei Yang , Xiaogang Wang

Learning directionality between variables is crucial yet challenging, especially for mechanistic relationships without a priori ordering assumptions. We propose a coefficient of asymmetry to quantify directional asymmetry using Shannon's…

Methodology · Statistics 2025-11-11 Soumik Purkayastha , Peter X. -K. Song

Contemporary techniques in biology produce readouts for large numbers of genes simultaneously, the typical example being differential gene expression measurements. Moreover, those genes are often richly annotated using GO terms that…

Genomics · Quantitative Biology 2016-02-24 Fran Supek , Nives Škunca

While much effort has focused on detecting positive and negative directional selection in the human genome, relatively little work has been devoted to balancing selection. This lack of attention is likely due to the paucity of sophisticated…

Populations and Evolution · Quantitative Biology 2013-07-17 Michael DeGiorgio , Kirk E. Lohmueller , Rasmus Nielsen

Precision medicine is a paradigm shift in healthcare relying heavily on genomics data. However, the complexity of biological interactions, the large number of genes as well as the lack of comparisons on the analysis of data, remain a…

With the rapid advancements in cancer research, the information that is useful for characterizing disease, staging tumors, and creating treatment and survivorship plans has been changing at a pace that creates challenges when physicians try…

Semantic sentence embedding models encode natural language sentences into vectors, such that closeness in embedding space indicates closeness in the semantics between the sentences. Bilingual data offers a useful signal for learning such…

Computation and Language · Computer Science 2020-11-20 John Wieting , Graham Neubig , Taylor Berg-Kirkpatrick

Latent Semantic Analysis is a method of matrix decomposition used for discovering topics and topic weights in natural language documents. This study uses Latent Semantic Analysis to analyze the composition of binaries of malicious programs.…

Cryptography and Security · Computer Science 2023-03-02 John Musgrave , Temesguen Messay-Kebede , David Kapp , Anca Ralescu

We propose a novel approach for disentangling visual and semantic features from the backbones of pre-trained diffusion models, enabling visual correspondence in a manner analogous to the well-established semantic correspondence. While…

Computer Vision and Pattern Recognition · Computer Science 2025-09-29 Abdelrahman Eldesokey , Aleksandar Cvejic , Bernard Ghanem , Peter Wonka

We consider a method to jointly estimate sparse precision matrices and their underlying graph structures using dependent high-dimensional datasets. We present a penalized maximum likelihood estimator which encourages both sparsity and…

Applications · Statistics 2016-08-22 Adria Caballe , Natalia Bochkina , Claus Mayer

The feature matching is a basic step in matching different datasets. This article proposes shows a new hybrid model of a pretrained Natural Language Processing (NLP) based model called BERT used in parallel with a statistical model based on…

Databases · Computer Science 2023-03-24 Muhammad Danial Khilji

The Jaccard similarity index has often been employed in science and technology as a means to quantify the similarity between two sets. When modified to operate on real-valued values, the Jaccard similarity index can be applied to compare…

Data Analysis, Statistics and Probability · Physics 2024-10-23 Gonzalo Travieso , Alexandre Benatti , Luciano da F. Costa

Stratifying cancer patients based on their gene expression levels allows improving diagnosis, survival analysis and treatment planning. However, such data is extremely highly dimensional as it contains expression values for over 20000 genes…

In microarray experiments, it is often of interest to identify genes which have a pre-specified gene expression profile with respect to time. Methods available in the literature are, however, typically not stringent enough in identifying…

Applications · Statistics 2009-01-18 J. Tuke , G. F. V. Glonek , P. J. Solomon