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The origin of rigidity in disordered materials is an outstanding open problem in statistical physics. Previously, a class of 2D cellular models has been shown to undergo a rigidity transition controlled by a mechanical parameter that…

Soft Condensed Matter · Physics 2023-01-18 Matthias Merkel , Lisa Manning

During morphogenesis, the shape of a tissue emerges from collective cellular behaviors, which are in part regulated by mechanical and biochemical interactions between cells. Quantification of force and stress is therefore necessary to…

Tissues and Organs · Quantitative Biology 2014-02-19 K. Sugimura , Y. Bellaïche , F. Graner , P. Marcq , S. Ishihara

Keratoconus is a pathology of the cornea associated with a tissue thinning and a weakening of its mechanical properties. However, it remains elusive which aspect is the leading cause of the disease. To investigate this question, we combined…

Medical Physics · Physics 2021-11-25 Chloé Giraudet , Jérome Diaz , Patrick Le Tallec , Jean-Marc Allain

In this work, we construct an effective continuum model for architected sheets that are composed of bulky tiles connected by slender elastic joints. Due to their mesostructure, these sheets feature quasi-mechanisms -- low-energy local…

Materials Science · Physics 2022-06-22 Connor McMahan , Andrew Akerson , Paolo Celli , Basile Audoly , Chiara Daraio

Tendon-driven musculoskeletal humanoids have many benefits in terms of the flexible spine, multiple degrees of freedom, and variable stiffness. At the same time, because of its body complexity, there are problems in controllability. First,…

Robotics · Computer Science 2024-04-09 Kento Kawaharazuka , Shogo Makino , Masaya Kawamura , Ayaka Fujii , Yuki Asano , Kei Okada , Masayuki Inaba

We describe a novel coarse-grained simulation method for modelling the dynamics of globular macromolecules, such as proteins. The macromolecule is treated as a continuum that is subject to thermal fluctuations. The model includes a…

Computational Physics · Physics 2015-06-11 Robin Oliver , Daniel J. Read , Oliver G. Harlen , Sarah A. Harris

We report detailed theoretical investigations of the micro-mechanics and bulk elastic properties of composites consisting of randomly distributed stiff fibers embedded in an elastic matrix in two and three dimensions. Recent experiments…

Soft Condensed Matter · Physics 2013-05-29 Moumita Das , F. C. MacKintosh

Cytoskeletal gels are prototyped to reproduce the mechanical contraction of the cytoskeleton in-vitro. They are composed of a polymer network (backbone), swollen by the presence of a liquid solvent, and active molecules (molecular motors,…

Soft Condensed Matter · Physics 2026-03-27 Matteo Ferraresso , Albert Kong , Mehadi Hasan , Gwynn J. Elfring , Daniele Agostinelli , Mattia Bacca

This paper presents an experimental investigation on pattern formation and evolution in bilayered tubular organs using swelling deformation of polydimethylsiloxane (PDMS) and aims at supplying a thorough comparison with theoretical and…

Soft Condensed Matter · Physics 2022-02-15 Rui-Cheng Liu , Lishuai Jin , Zongxi Cai , Yang Liu

We present a statistical mechanical study of stiff polymers, motivated by experiments on actin filaments and the considerable current interest in polymer networks. We obtain simple, approximate analytical forms for the force-extension…

Soft Condensed Matter · Physics 2009-11-13 Abhijit Ghosh , Joseph Samuel , Supurna Sinha

We propose a simple and practical approach for incorporating the effects of muscle inertia, which has been ignored by previous musculoskeletal simulators in both graphics and biomechanics. We approximate the inertia of the muscle by…

Graphics · Computer Science 2022-09-23 Ying Wang , Jasper Verheul , Sang-Hoon Yeo , Nima Khademi Kalantari , Shinjiro Sueda

The buckling of a soft elastic sample under growth or swelling has highlighted a new interest in materials science, morphogenesis, and biology or physiology. Indeed, the change of mass or volume is a common fact of any living species, and…

Soft Condensed Matter · Physics 2023-09-21 Martine Ben Amar

We study a material modeled as a network of nodes connected by edges. Using a discrete approach, we build a nonlinear algebraic system that connects applied forces to internal forces and node positions. The model can describe elasticity,…

Optimization and Control · Mathematics 2025-10-14 Ioannis Dassios

Collagen fibrils are the building block of many biological tissues, which viability depend on the fibrils properties. Altered properties of collagen fibrils are central to the appearance of many diseases, while physiological or native…

Soft Condensed Matter · Physics 2026-05-08 Konstantinos Steiakakis , Alan Pichard , Maxime Vassaux

The tendon-driven musculoskeletal humanoid has many benefits that human beings have, but the modeling of its complex muscle and bone structures is difficult and conventional model-based controls cannot realize intended movements. Therefore,…

During animal development and homeostasis, the structure of tissues, including muscles, blood vessels and connective tissues adapts to mechanical strains in the extracellular matrix (ECM). These strains originate from the differential…

Cell Behavior · Quantitative Biology 2017-03-06 Elisabeth G. Rens , Roeland M. H. Merks

Recent developments of microscopic mechanical experiments allow the manipulation of individual polymer molecules in two main ways: \textit{uniform} stretching by external forces and \textit{non-uniform} stretching by external fields. Many…

Biological Physics · Physics 2015-06-11 Fabio Manca , Stefano Giordano , Pier Luca Palla , Fabrizio Cleri , Luciano Colombo

Bone is a stiff and though, hierarchical and continuously evolving material that optimizes its structure to respond to mechanical stimuli, which also govern growth and remodeling processes. However, a full understanding of the underlying…

Applied Physics · Physics 2022-06-30 M. Fraldi , A. Cutolo , A. R. Carotenuto , S. Palumbo , F. Bosia , N. M. Pugno

We study the shapes of elastic membranes under the simultaneous exertion of tensile and compressive forces when the translational symmetry along the tension direction is broken. We predict a multitude of novel morphological phases in…

Soft Condensed Matter · Physics 2015-05-13 Benny Davidovitch

Musculoskeletal (MSK) models offer a non-invasive way to understand biomechanical loads on joints and tendons, which are difficult to measure directly. Variations in muscle strength, especially relative differences between muscles,…

Tissues and Organs · Quantitative Biology 2025-10-13 R. Maarleveld , H. E. J. Veeger , F. C. T. van der Helm , J. Son , R. L. Lieber , E. van der Kruk