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Biologists have found that the death rate of cells in culture depends upon their spatial density. Permanent "Stay alive" signals from their neighbours seem to prevent them from dying. In a previous paper (Wang et al. 2013) we gave evidence…

Physics and Society · Physics 2013-06-24 Lei Wang , Yijuan Xu , Zengru Di , Bertrand M. Roehner

In this work we examine the properties of a recently described ordinary differential equation that relates the age-specific prevalence of a chronic disease with the incidence and mortalities of the diseased and healthy persons. The equation…

Quantitative Methods · Quantitative Biology 2012-08-28 Ralph Brinks

In epidemiological or demographic studies, with variable age at onset, a typical quantity of interest is the incidence of a disease (for example the cancer incidence). In these studies, the individuals are usually highly heterogeneous in…

Statistics Theory · Mathematics 2025-05-20 Vivien Goepp , Jean-Christophe Thalabard , Grégory Nuel , Olivier Bouaziz

This paper introduces a novel measure to quantify the directional dependence of extreme events between two variables. The proposed approach is designed to capture asymmetric tail dependence by studying conditional tail expectations of…

Methodology · Statistics 2026-04-06 Matthieu Garcin , Maxime L. D. Nicolas

The probabilistic explanation of the direct and reverse cohort component population projection methods is presented. The main characteristics determining the probability distribution of the values for the direct and reverse component…

Methodology · Statistics 2021-09-28 Mariia Nosova

Excess mortality, i.e. the difference between expected and observed mortality, is used to quantify the death toll of mortality shocks, such as infectious disease-related epidemics and pandemics. However, predictions of expected mortality…

Applications · Statistics 2025-02-18 Ainhoa-Elena Leger , Silvia Rizzi , Ugofilippo Basellini

This paper considers the problem of forecasting mortality rates. A large number of models have already been proposed for this task, but they generally have the disadvantage of either estimating the model in a two-step process, possibly…

Applications · Statistics 2023-05-26 Patrik Andersson , Mathias Lindholm

This paper introduces new methods to track the offset between two multivariate time series on a continuous basis. We then apply this framework to COVID-19 counts on a state-by-state basis in the United States to determine the progression…

Physics and Society · Physics 2022-12-19 Nick James , Max Menzies

In this paper we investigate the flexibility of matrix distributions for the modeling of mortality. Starting from a simple Gompertz law, we show how the introduction of matrix-valued parameters via inhomogeneous phase-type distributions can…

Methodology · Statistics 2022-08-03 Hansjoerg Albrecher , Martin Bladt , Mogens Bladt , Jorge Yslas

This paper descibes a new method of calculating the mean duration and mean age of onset of a chronic disease from incidence and mortality rates. It is based on an ordinary differential equation resulting from a simple compartment model.…

Quantitative Methods · Quantitative Biology 2011-12-30 Ralph Brinks

We study in details the turnout rate statistics for 77 elections in 11 different countries. We show that the empirical results established in a previous paper for French elections appear to hold much more generally. We find in particular…

Physics and Society · Physics 2015-06-03 Christian Borghesi , Jean-Claude Raynal , Jean-Philippe Bouchaud

This report provides a visual examination of Covid-19 case and death data. In particular, it shows that country specific differences can too a large extend be explained by two easily interpreted parameters. Namely, the delay between…

Populations and Evolution · Quantitative Biology 2020-04-17 Nils Bertschinger

Various stochastic models have been proposed to estimate mortality rates. In this paper we illustrate how machine learning techniques allow us to analyze the quality of such mortality models. In addition, we present how these techniques can…

Applications · Statistics 2017-05-10 Philippe Deprez , Pavel V. Shevchenko , Mario V. Wüthrich

Measures of tail dependence between random variables aim to numerically quantify the degree of association between their extreme realizations. Existing tail dependence coefficients (TDCs) are based on an asymptotic analysis of relevant…

Applications · Statistics 2021-06-11 Davide Lauria , Svetlozar T. Rachev , A. Alexandre Trindade

In this paper, we examine cross-country differences, in terms of the age distribution of symptomatic cases, hospitalizations, intensive care unit (ICU) cases, and fatalities due to the novel COVID-19. By calculating conditional…

Quantitative Methods · Quantitative Biology 2020-04-15 Enes Eryarsoy , Dursun Delen

We propose a probabilistic mortality forecasting model that can be applied to derive forecasts for populations with regular and irregular mortality developments. Our model (1) uses rates of mortality improvement to model dynamic age…

Applications · Statistics 2014-01-14 Christina Bohk , Roland Rau

Understanding how the causal effect of a treatment evolves over time, including the potential for waning, is important for informed decisions on treatment discontinuation or repetition. For example, waning vaccine protection influences…

Methodology · Statistics 2025-11-25 Eni Musta , Joris Mooij

The aim of this paper is to propose a realistic and operational model to quantify the systematic risk of mortality included in an engagement of retirement. The model presented is built on the basis of model of Lee-Carter. The stochastic…

General Finance · Quantitative Finance 2010-01-13 Frédéric Planchet , Laurent Faucillon , Marc Juillard

The EU Solvency II directive recommends insurance companies to pay more attention to the risk management methods. The sense of risk management is the ability to quantify risk and apply methods that reduce uncertainty. In life insurance, the…

Econometrics · Economics 2018-04-02 Kamil Jodź

The COVID-19 pandemic has had high mortality rates in the elderly and frail worldwide, particularly in care homes. This is driven by the difficulty of isolating care homes from the wider community, the large population sizes within care…