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Epidemiology characterizes the influence of causes to disease and health conditions of defined populations. Cohort studies are population-based studies involving usually large numbers of randomly selected individuals and comprising numerous…

Computer Vision and Pattern Recognition · Computer Science 2015-01-19 Bernhard Preim , Paul Klemm , Helwig Hauser , Katrin Hegenscheid , Steffen Oeltze , Klaus Toennies , Henry Völzke

The methods used so far for the analysis of time changes in population health suffer from the lack of causality in their design. This results in problems with their implementation and interpretation. Here the method is presented with…

Applications · Statistics 2016-02-19 Vladislav Moltchanov

We study the dynamics of cause--specific mortality rates among countries by considering them as compositions of functions. We develop a novel framework for such data structure, with particular attention to functional PCA. The application of…

Methodology · Statistics 2020-08-03 Marco Stefanucci , Stefano Mazzuco

In this paper, we provide a comprehensive cross-country validation study of compositional mortality modeling and forecasting methods. Thus, we consider two one-to-one transformations: the cumulative distribution function and the centered…

Applications · Statistics 2026-03-20 Han Lin Shang , Steven Haberman

This paper considers identification and estimation of distributional effect parameters that depend on the joint distribution of an outcome and another variable of interest ("treatment") in a setting with "two-sided" measurement error --…

Econometrics · Economics 2025-09-23 Brantly Callaway , Tong Li , Irina Murtazashvili , Emmanuel Tsyawo

Different ways of calculating mortality ratios during epidemics have yielded very different results, particularly during the current COVID-19 pandemic. We formulate both a survival probability model and an associated infection…

Populations and Evolution · Quantitative Biology 2020-10-06 Lucas Böttcher , Mingtao Xia , Tom Chou

In this work we present a spatial approach to model and investigate mortality data referenced over a Lexis structure. We decompose the force of mortality into two interpretable components: a Markov random field, smooth with respect to time,…

Applications · Statistics 2018-10-23 Fabio Divino , Denekew Bitew Belay , Nico Keilman , Arnoldo Frigessi

A common goal in modeling demographic rates is to compare two or more groups. For ex- ample comparing mortality rates between men and women or between geographic regions may reveal health inequalities. A popular class of models for…

Methodology · Statistics 2018-06-08 Theresa Smith

Longitudinal studies are often conducted to explore the cohort and age effects in many scientific areas. The within cluster correlation structure plays a very important role in longitudinal data analysis. This is because not only can an…

Statistics Theory · Mathematics 2008-12-18 Yan Sun , Wenyang Zhang , Howell Tong

We investigate jointly modeling Age-specific rates of various causes of death in a multinational setting. We apply Multi-Output Gaussian Processes (MOGP), a spatial machine learning method, to smooth and extrapolate multiple cause-of-death…

Applications · Statistics 2021-11-15 Nhan Huynh , Mike Ludkovski

In the aftermath of the COVID-19 pandemic, empirical data have revealed that large-scale health crises not only cause immediate disruptions in mortality dynamics but also have persistent effects that may last for several years. Existing…

Applications · Statistics 2026-03-26 Yanxin Liu , Kenneth Q. Zhou

Aging is a multidimensional process where phenotypes change at varying rates. Longitudinal studies of aging typically involve following a cohort of individuals over the course of several years. This design is hindered by cost, attrition,…

Understanding and forecasting mortality by cause is an essential branch of actuarial science, with wide-ranging implications for decision-makers in public policy and industry. To accurately capture trends in cause-specific mortality, it is…

Applications · Statistics 2025-10-21 Zhe Michelle Dong , Han Lin Shang , Francis Hui , Aaron Bruhn

Stratifying factors, like age and gender, can modify the effect of treatments and exposures on risk of a studied outcome. Several effect measures, including the relative risk, hazard ratio, odds ratio, and risk difference, can be used to…

Methodology · Statistics 2021-11-05 Jake Shannin , Babette A. Brumback

Understanding patterns in mortality across subpopulations is essential for local health policy decision making. One of the key challenges of subnational mortality rate estimation is the presence of small populations and zero or near zero…

Applications · Statistics 2025-12-16 Ameer Dharamshi , Monica Alexander , Celeste Winant , Magali Barbieri

The issue of longevity has been long time recognized as one of key concepts in demography. A particular aspect of longevity addressed in this paper is the difference in average observed duration of life for female and male population,…

Physics and Society · Physics 2019-05-09 Toni Cosic , Roko Misetic , Hrvoje Stefancic

There is an increasing interest in estimating heterogeneity in causal effects in randomized and observational studies. However, little research has been conducted to understand heterogeneity in an instrumental variables study. In this work,…

Methodology · Statistics 2021-01-20 Michael Johnson , Jiongyi Cao , Hyunseung Kang

Multivariate functional data that are cross-sectionally compositional data are attracting increasing interest in the statistical modeling literature, a major example being trajectories over time of compositions derived from cause-specific…

Methodology · Statistics 2023-11-21 Emanuele Giovanni Depaoli , Marco Stefanucci , Stefano Mazzuco

We consider a compositional data analysis approach to forecasting the age distribution of death counts. Using the age-specific period life-table death counts in Australia obtained from the Human Mortality Database, the compositional data…

Applications · Statistics 2020-09-22 Han Lin Shang , Steven Haberman

Producing subnational estimates of the under-five mortality rate (U5MR) is a vital goal for the United Nations to reduce inequalities in mortality and well-being across the globe. There is a great disparity in U5MR between high-income and…

Applications · Statistics 2023-09-06 Connor Gascoigne , Theresa Smith , John Paige , Jon Wakefield