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In biomolecular systems (especially all-atom models) with many degrees of freedom such as proteins and nucleic acids, there exist an astronomically large number of local-minimum-energy states. Conventional simulations in the canonical…

Statistical Mechanics · Physics 2010-12-30 Ayori Mitsutake , Yoshiharu Mori , Yuko Okamoto

Simulated quantum annealing is a generic classical protocol to simulate some aspects of quantum annealing and is sometimes regarded as a classical alternative to quantum annealing in finding the ground state of a classical Ising model. We…

Quantum Physics · Physics 2022-12-21 Yusuke Kimura , Hidetoshi Nishimori

In complex systems with many degrees of freedom such as spin glass and biomolecular systems, conventional simulations in canonical ensemble suffer from the quasi-ergodicity problem. A simulation in generalized ensemble performs a random…

Statistical Mechanics · Physics 2008-06-24 Y. Okamoto

Many important challenges in science and technology can be cast as optimization problems. When viewed in a statistical physics framework, these can be tackled by simulated annealing, where a gradual cooling procedure helps search for…

Disordered Systems and Neural Networks · Physics 2024-01-17 Mohamed Hibat-Allah , Estelle M. Inack , Roeland Wiersema , Roger G. Melko , Juan Carrasquilla

Quantum annealing is a general strategy for solving difficult optimization problems with the aid of quantum adiabatic evolution. Both analytical and numerical evidence suggests that under idealized, closed system conditions, quantum…

Real life quantum computers are inevitably affected by intrinsic noise resulting in dissipative non-unitary dynamics realized by these devices. We consider an open system quantum annealing algorithm optimized for a realistic analog quantum…

Quantum Physics · Physics 2016-06-08 Kostyantyn Kechedzhi , Vadim N. Smelyanskiy

The population annealing algorithm is a population-based equilibrium version of simulated annealing. It can sample thermodynamic systems with rough free-energy landscapes more efficiently than standard Markov chain Monte Carlo alone. A…

Statistical Mechanics · Physics 2024-01-17 Denis Gessert , Wolfhard Janke , Martin Weigel

Population annealing is a recent addition to the arsenal of the practitioner in computer simulations in statistical physics and beyond that is found to deal well with systems with complex free-energy landscapes. Above all else, it promises…

Statistical Mechanics · Physics 2021-05-05 Martin Weigel , Lev Yu. Barash , Lev N. Shchur , Wolfhard Janke

Quantum annealing is a computational paradigm in which optimisation problems are mapped onto the energy landscape of an interacting quantum system and explored through its dynamical evolution. By continuously transforming a simple initial…

Quantum Physics · Physics 2026-05-11 Steven Abel , Andrei Constantin , Luca A. Nutricati

The effectiveness of a new algorithm, parallel tempering, is studied for numerical simulations of biological molecules. These molecules suffer from a rough energy landscape. The resulting slowing down in numerical simulations is overcome by…

Chemical Physics · Physics 2009-10-30 Ulrich H. E. Hansmann

Ensemble calculations are essential for systems with uncertain data but require substantial increase in computational resources. This increase severely limits ensemble size. To reach beyond current limits, we present a first-order…

Numerical Analysis · Mathematics 2017-12-19 Joseph A. Fiordilino , Michael McLaughlin

The most efficient MC weights for the calculation of physical, canonical expectation values are not necessarily those of the canonical ensemble. The use of suitably generalized ensembles can lead to a much faster convergence of the…

Statistical Mechanics · Physics 2011-01-24 Bernd A. Berg

We introduce an algorithm to systematically improve the efficiency of parallel tempering Monte Carlo simulations by optimizing the simulated temperature set. Our approach is closely related to a recently introduced adaptive algorithm that…

Other Condensed Matter · Physics 2007-05-23 Helmut G. Katzgraber , Simon Trebst , David A. Huse , Matthias Troyer

Quantum annealing method has been widely attracted attention in statistical physics and information science since it is expected to be a powerful method to obtain the best solution of optimization problem as well as simulated annealing. The…

Disordered Systems and Neural Networks · Physics 2017-08-23 Shu Tanaka , Ryo Tamura

A major challenge in simulating glassy systems is the ability to generate configurations that may be found in equilibrium at sufficiently low temperatures, in order to probe static and dynamic behaviour close to the glass transition. A…

Soft Condensed Matter · Physics 2024-06-19 Pallabi Das , Anshul D. S. Parmar , Srikanth Sastry

Parallel Quantum Annealing is a technique to solve multiple optimization problems simultaneously. Parallel quantum annealing aims to optimize the utilization of available qubits on a quantum topology by addressing multiple independent…

Quantum Physics · Physics 2024-03-12 Arit Kumar Bishwas , Anuraj Som , Saurabh Choudhary

The sampling problem lies at the heart of atomistic simulations and over the years many different enhanced sampling methods have been suggested towards its solution. These methods are often grouped into two broad families. On the one hand…

Computational Physics · Physics 2020-11-25 Michele Invernizzi , Pablo Miguel Piaggi , Michele Parrinello

I propose a "quantum annealing" heuristic for the problem of combinatorial search among a frustrated set of states characterized by a cost function to be minimized. The algorithm is probabilistic, with postselection of the measurement…

Quantum Physics · Physics 2009-11-07 Carlo A. Trugenberger

Quantum annealing is a promising technique which leverages quantum mechanics to solve hard optimization problems. Considerable progress has been made in the development of a physical quantum annealer, motivating the study of methods to…

Quantum Physics · Physics 2017-04-21 Maritza Hernandez , Maliheh Aramon

Simulated annealing provides a heuristic solution to combinatorial optimization problems. The cost function of a problem is mapped onto the energy function of a physical many-body system, and, by using thermal or quantum fluctuations, the…

Statistical Mechanics · Physics 2025-12-05 Yoshiaki Horiike , Yuki Kawaguchi