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We study a combinatorial problem arising from microarrays synthesis. The synthesis is done by a light-directed chemical process. The objective is to minimize unintended illumination that may contaminate the quality of experiments.…
Protein/Peptide microarrays are rapidly gaining momentum in the diagnosis of cancer. High-density and highthroughput peptide arrays are being extensively used to detect tumor biomarkers, examine kinase activity, identify antibodies having…
We show that the Minimal Length-Bounded L-But problem can be computed in linear time with respect to L and the tree-width of the input graph as parameters. In this problem the task is to find a set of edges of a graph such that after…
We study computational complexity of the class of distance-constrained graph labeling problems from the fixed parameter tractability point of view. The parameters studied are neighborhood diversity and clique width. We rephrase the distance…
The maximum modularity of a graph is a parameter widely used to describe the level of clustering or community structure in a network. Determining the maximum modularity of a graph is known to be NP-complete in general, and in practice a…
When considering a graph problem from a parameterized point of view, the parameter chosen is often the size of an optimal solution of this problem (the "standard" parameter). A natural subject for investigation is what happens when we…
We study the complexity of the problem of searching for a set of patterns that separate two given sets of strings. This problem has applications in a wide variety of areas, most notably in data mining, computational biology, and in…
Given a graph G, a matching is a subset of edges of G that do not share an endpoint. A matching M is uniquely restricted if the subgraph induced by the endpoints of the edges of M has exactly one perfect matching. Given a graph G and a…
Combining the techniques of approximation algorithms and parameterized complexity has long been considered a promising research area, but relatively few results are currently known. In this paper we study the parameterized approximability…
Parameterized complexity enables the practical solution of generally intractable NP-hard problems when certain parameters are small, making it particularly useful in real-world applications. The study of string problems in this framework…
We consider the well-studied problem of finding a spanning tree with minimum average distance between vertex pairs (called a MAD tree). This is a classic network design problem which is known to be NP-hard. While approximation algorithms…
Finding the smallest $d$-chain with a specific $(d-1)$-boundary in a simplicial complex is known as the \textsc{Minimum Bounded Chain} (MBC$_d$) problem. The MBC$_d$ problem is NP-hard for all $d\geq 2$. In this paper, we prove that it is…
In this paper, we study the parameterized complexity of local search, whose goal is to find a good nearby solution from the given current solution. Formally, given an optimization problem where the goal is to find the largest feasible…
A metro-line crossing minimization problem is to draw multiple lines on an underlying graph that models stations and rail tracks so that the number of crossings of lines becomes minimum. It has several variations by adding restrictions on…
A parameterized string (p-string) is a string over an alphabet $(\Sigma_{s} \cup \Sigma_{p})$, where $\Sigma_{s}$ and $\Sigma_{p}$ are disjoint alphabets for static symbols (s-symbols) and for parameter symbols (p-symbols), respectively.…
The study of genetic map linearization leads to a combinatorial hard problem, called the {\em minimum breakpoint linearization} (MBL) problem. It is aimed at finding a linearization of a partial order which attains the minimum breakpoint…
We study integer linear programs (ILP) of the form $\min\{c^\top x\ \vert\ Ax=b,l\le x\le u,x\in\mathbb Z^n\}$ and analyze their parameterized complexity with respect to their distance to the generalized matching problem, following the…
A set $S$ of vertices of a graph is a defensive alliance if, for each element of $S$, the majority of its neighbours is in $S$. We consider the notion of local minimality in this paper. We are interested in locally minimal defensive…
In this paper we study the complexity of the following problems: Given a colored graph X=(V,E,c), compute a minimum cardinality set S of vertices such that no nontrivial automorphism of X fixes all vertices in S. A closely related problem…
Many graph problems were first shown to be fixed-parameter tractable using the results of Robertson and Seymour on graph minors. We show that the combination of finite, computable, obstruction sets and efficient order tests is not just one…