Related papers: Development of aging changes: self-accelerating an…
The development of multicellular organisms proceeds through a series of morphogenetic and cell-state transitions, transforming homogeneous zygotes into complex adults by a process of self-organization. Many of these transitions are achieved…
Living systems are subject to the arrow of time; from birth, they undergo complex transformations (self-organization) in a constant battle for survival, but inevitably ageing and disease trap them to death. Can ageing be understood and…
Surface growth is a crucial component of many natural and artificial processes from cell proliferation to additive manufacturing. In elastic systems surface growth is usually accompanied by the development of geometrical incompatibility…
Understanding the emergence and evolution of multicellularity and cellular differentiation is a core problem in biology. We develop a quantitative model that shows that a multicellular form emerges from genetically identical unicellular…
We introduce a set of theoretical ideas that form the basis for an analytical framework capable of describing nonequilibrium dynamics in glassy systems. We test the resulting scenario by comparing its predictions with numerical simulations…
Aging in kinetics of three different phase transitions, viz., magnetic, binary solid and single component fluid, have been studied via Monte Carlo and molecular dynamics simulations in three space dimensions with the objective of…
The diffusion in the comb structures is a popular model of geometrically induced anomalous diffusion. In the present work we concentrate on the diffusion along the backbone in a system where sidebranches are planes, and the diffusion…
Phase separation in passive systems leads to uncontrolled droplet growth, limiting structural control in soft materials and cells. We identify a generic mechanism to arrest coarsening based on chemical interconversion between molecular…
We report results of molecular dynamics simulations of a binary Lennard-Jones system at zero pressure in the undercooled liquid and glassy states. We first follow the evolution of diffusivity and dynamic heterogeneity with temperature and…
Aging in complex systems is studied via the sandpile model. Relaxation of avalanches in sandpiles is observed to depend on the time elapsed since the begining of the relaxation. Levy behavior is observed in the distribution of…
Recent studies have shown that even in the absence of extrinsic stress, the morphologically symmetrically dividing model bacteria Escherichia coli do not generate offspring with equal reproductive fitness. Instead, daughter cells exhibit…
Slow relaxation occurs in many physical and biological systems. `Creep' is an example from everyday life: when stretching a rubber band, for example, the recovery to its equilibrium length is not, as one might think, exponential: the…
We consider a simple model of a structural glass, represented by a lattice gas with kinetic constraints in contact with a particle reservoir. Quench below the glass transition is represented by the jump of the chemical potential above a…
We use confocal microscopy to study the aging of a bidisperse colloidal glass near rough and smooth boundaries. Near smooth boundaries, the particles form layers, and particle motion is dramatically slower near the boundary as compared to…
Advances in healthcare and in the quality of life significantly increase human life expectancy. With the ageing of populations, new un-faced challenges are brought to science. The human body is naturally selected to be well-functioning…
Atherosclerotic plaques form in artery walls due to a chronic inflammatory response driven by lipid accumulation. A key component of the inflammatory response is the interaction between monocyte-derived macrophages and extracellular lipid.…
Ignoring the differences between countries, human reproductive and dispersal behaviors can be described by some standardized models, so whether there is a universal law of population growth hidden in the abundant and unstructured data from…
We investigate how cyclic loading evolves the structure and deformation behaviors of a granular raft composed of particles floating at an air-oil interface. The raft has a disordered particle packing structure, and is cohesive due to…
Growth-induced instabilities are ubiquitous in biological systems and lead to diverse morphologies in the form of wrinkling, folding, and creasing. The current work focusses on the mechanics behind growth-induced wrinkling instabilities in…
Hypertension is one of the most common age-related chronic diseases and by predisposing individuals for heart failure, stroke and kidney disease, it is a major source of morbidity and mortality. Its etiology remains enigmatic despite…