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Randomized trials of infectious disease interventions, such as vaccines, often focus on groups of connected or potentially interacting individuals. When the pathogen of interest is transmissible between study subjects, interference may…

Applications · Statistics 2019-12-10 Daniel J. Eck , Olga Morozova , Forrest W. Crawford

Network-based intervention strategies can be effective and cost-efficient approaches to curtailing harmful contagions in myriad settings. As studied, these strategies are often impractical to implement, as they typically assume complete…

Physics and Society · Physics 2020-09-09 Samuel F. Rosenblatt , Jeffrey A. Smith , G. Robin Gauthier , Laurent Hébert-Dufresne

We study vaccine budget-sharing strategies in the SIR (Susceptible-Infected-Recovered) model given a structured community network to investigate the benefit of sharing vaccine across communities. The network studied comprises two…

Physics and Society · Physics 2023-11-14 Felippe Alves , David Saad

Many interventions, such as vaccines in clinical trials or coupons in online marketplaces, must be assigned sequentially without full knowledge of their effects. Multi-armed bandit algorithms have proven successful in such settings.…

Machine Learning · Statistics 2026-05-07 Aidan Gleich , Eric Laber , Alexander Volfovsky

Vaccinations are an important tool in the prevention of disease. Vaccinations are generally voluntary for each member of a population and vaccination decisions are influenced by individual risk perceptions and contact structures within…

Physics and Society · Physics 2025-04-07 Kausutua Tjikundi , Mark Broom

Modeling human behavior is essential to accurately predict epidemic spread, with behaviors like vaccine hesitancy complicating control efforts. While epidemic spread is often treated as a simple contagion, vaccine uptake may follow complex…

Physics and Society · Physics 2024-12-17 Alfonso de Miguel-Arribas , Alberto Aleta , Yamir Moreno

Spreading processes represent a very efficient tool to investigate the structural properties of networks and the relative importance of their constituents, and have been widely used to this aim in static networks. Here we consider simple…

Physics and Society · Physics 2013-09-11 Michele Starnini , Anna Machens , Ciro Cattuto , Alain Barrat , Romualdo Pastor Satorras

Cluster-randomized trials are often conducted to assess vaccine effects. Defining estimands of interest before conducting a trial is integral to the alignment between a study's objectives and the data to be collected and analyzed. This…

Methodology · Statistics 2019-10-10 Kayla W. Kilpatrick , Michael G. Hudgens , M. Elizabeth Halloran

Controlling and understanding epidemic outbreaks has recently drawn great interest in a large spectrum of research communities. Vaccination is one of the most well-established and effective strategies in order to contain an epidemic. In the…

Social and Information Networks · Computer Science 2023-05-29 Sourin Chatterjee , Ahad N. Zehmakan

We introduce an immunization method where the percentage of required vaccinations for immunity are close to the optimal value of a targeted immunization scheme of highest degree nodes. Our strategy retains the advantage of being purely…

Physics and Society · Physics 2009-11-13 Lazaros K. Gallos , Fredrik Liljeros , Panos Argyrakis , Armin Bunde , Shlomo Havlin

When consequential decisions are informed by algorithmic input, individuals may feel compelled to alter their behavior in order to gain a system's approval. Models of agent responsiveness, termed "strategic manipulation," analyze the…

Machine Learning · Computer Science 2019-05-13 Lily Hu , Nicole Immorlica , Jennifer Wortman Vaughan

Background: Network-based interventions are most powerful against epidemics when the full network structure is known. However, resource constraints often require decisions based on partial network data. We investigated how the effectiveness…

Populations and Evolution · Quantitative Biology 2018-03-30 Yingrui Yang , Ashley McKhann , Guy Harling , Jukka-Pekka Onnela

Vaccination is an effective way to prevent and control the occurrence and epidemic of infectious diseases. However, many factors influence whether the residents decide to get vaccinated or not, such as the efficacy and side effects while…

Physics and Society · Physics 2022-03-09 Yingyue Ke , Jin Zhou

The impact of information dissemination on epidemic control is essentially subject to individual behaviors. Unlike information-driven behaviors, vaccination is determined by many cost-related factors, whose correlation with the information…

Physics and Society · Physics 2019-04-03 Xiao-Jie Li , Cong Li , Xiang Li

Vaccination has played an important role in preventing the spread of infectious diseases. However, the limited availability of vaccines and personnel at the roll-out of a new vaccine and the costs of vaccination campaigns often limit how…

Physics and Society · Physics 2026-01-27 Rowan Hoogervorst , Evelien van der Hurk , David Pisinger

In this work we analyze the evolution of voluntary vaccination in networked populations by entangling the spreading dynamics of an influenza-like disease with an evolutionary framework taking place at the end of each influenza season so…

Physics and Society · Physics 2013-09-11 Alessio Cardillo , Catalina Reyes-Suárez , Fernando Naranjo , Jesús Gómez-Gardeñes

We investigate methods to vaccinate contact networks -- i.e. removing nodes in such a way that disease spreading is hindered as much as possible -- with respect to their cost-efficiency. Any real implementation of such protocols would come…

Populations and Evolution · Quantitative Biology 2017-11-01 Petter Holme , Nelly Litvak

In this paper we quantify the total economic impact of an epidemic over a complex network using tools from random matrix theory. Incorporating the direct and indirect costs of infection, we calculate the disease cost in the large graph…

Social and Information Networks · Computer Science 2013-09-10 Subhonmesh Bose , Elizabeth Bodine-Baron , Babak Hassibi , Adam Wierman

We examine here the effects of recurrent vaccination and waning immunity on the establishment of an endemic equilibrium in a population. An individual-based model that incorporates memory effects for transmission rate during infection and…

Populations and Evolution · Quantitative Biology 2024-11-22 Félix Foutel-Rodier , Arthur Charpentier , Hélène Guérin

The propagation of model epidemics on a small-world network under the action of immunization is studied. Although the connectivity in this kind of networks is rather uniform, a vaccination strategy focused on the best connected individuals…

Statistical Mechanics · Physics 2009-11-07 Damian H. Zanette , Marcelo Kuperman