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The dynamics of cellular aggregates is driven by the interplay of mechanochemical processes and cellular activity. Although deterministic models may capture mechanical features, local chemical fluctuations trigger random cell responses,…

Soft Condensed Matter · Physics 2024-01-17 Ana Carpio , Elena Cebrian

Chemical reactions inside cells are generally considered to happen within fixed-size compartments. Needless to say, cells and their compartments are highly dynamic. Thus, such stringent assumptions may not reflect biochemical reality, and…

Quantitative Methods · Quantitative Biology 2016-02-17 Atiyo Ghosh , Tatiana T. Marquez-Lago

Sensory systems have evolved to respond to input stimuli of certain statistical properties, and to reliably transmit this information through biochemical pathways. Hence, for an experimentally well-characterized sensory system, one ought to…

Cell Behavior · Quantitative Biology 2014-10-30 Diana Clausznitzer , Gabriele Micali , Silke Neumann , Victor Sourjik , Robert G. Endres

Bacterial growth environment strongly influences the efficacy of antibiotic treatment, with slow growth often being associated with decreased susceptibility. Yet in many cases the connection between antibiotic susceptibility and pathogen…

Cell Behavior · Quantitative Biology 2015-05-06 Philip Greulich , Matthew Scott , Martin R. Evans , Rosalind J. Allen

Chemotaxis enables marine bacteria to increase encounters with phytoplankton cells by reducing their search times, provided that bacteria detect noisy chemical gradients around phytoplankton. Gradient detection depends on bacterial…

Biological Physics · Physics 2025-01-14 Riccardo Foffi , Douglas R. Brumley , François Peaudecerf , Roman Stocker , Jonasz Słomka

In order to grow in any given environment, bacteria need to collect information about the medium composition and implement suitable growth strategies by adjusting their regulatory and metabolic degrees of freedom. In the standard sense,…

Biological Physics · Physics 2023-03-22 Anna Paola Muntoni , Andrea De Martino

A common feature of biological self-organization is how active agents communicate with each other or their environment via chemical signaling. Such communications, mediated by self-generated chemical gradients, have consequences for both…

Soft Condensed Matter · Physics 2023-11-07 Babak Vajdi Hokmabad , Suropriya Saha , Jaime Agudo-Canalejo , Ramin Golestanian , Corinna C. Maass

Hybrid models of chemotaxis combine agent-based models of cells with partial differential equation models of extracellular chemical signals. In this paper, travelling wave properties of hybrid models of bacterial chemotaxis are…

Biological Physics · Physics 2013-02-13 Benjamin Franz , Chuan Xue , Kevin J. Painter , Radek Erban

Magnetotactic swimmers tend to align along magnetic field lines against stochastic reorientations. We show that the swimming strategy, e.g. active Brownian motion versus run-and-tumble dynamics, strongly affects the orientation statistics.…

Run-and-tumble is a common but vital strategy that bacteria employ to explore environment suffused with boundaries, as well as to escape from entrapment. In this study we reveal how this strategy and the resulting dynamical behavior can be…

Soft Condensed Matter · Physics 2025-01-30 Premkumar Leishangthem , Xuan Wang , Junan Chen , Shengqi Yang , Xinliang Xu

We consider self-propelled particles undergoing run-and-tumble dynamics (as exhibited by E. coli) in one dimension. Building on previous analyses at drift-diffusion level for the one-particle density, we add both interactions and noise,…

Statistical Mechanics · Physics 2008-08-14 J. Tailleur , M. E. Cates

The large scale behaviour of a population of cells that grow and interact through the concentration field of the chemicals they secrete is studied using dynamical renormalization group methods. The combination of the effective long-range…

Cell Behavior · Quantitative Biology 2015-01-19 Anatolij Gelimson , Ramin Golestanian

In bacterial chemotaxis, E. coli cells drift up chemical gradients by a series of runs and tumbles. Runs are periods of directed swimming, and tumbles are abrupt changes in swimming direction. Near the beginning of each run, the rotating…

Soft Condensed Matter · Physics 2009-11-07 Thomas R. Powers

We have measured the spatial distribution of motile Escherichia coli inside spherical water droplets emulsified in oil. At low cell concentrations, the cell density peaks at the water-oil interface; at increasing concentration, the bulk of…

Many experiments in recent years have reported that, when exposed to their corresponding substrate, catalytic enzymes undergo enhanced diffusion as well as chemotaxis (biased motion in the direction of a substrate gradient). Among other…

Soft Condensed Matter · Physics 2020-11-17 Jaime Agudo-Canalejo , Ramin Golestanian

Enzymes have been recently proposed to have mechanical activity associated with their chemical activity. In a number of recent studies, it has been reported that enzymes undergo enhanced diffusion in the presence of their corresponding…

Biological Physics · Physics 2021-04-07 Jaime Agudo-Canalejo , Tunrayo Adeleke-Larodo , Pierre Illien , Ramin Golestanian

Chemotaxis is a directed cell movement in response to external chemical stimuli. In this paper, we propose a simple model for the origin of chemotaxis - namely how a directed movement in response to an external chemical signal may occur…

Analysis of PDEs · Mathematics 2023-06-30 Yishu Gong , Alexander Kiselev

The behaviour of an organism often reflects a strategy for coping with its environment. Such behaviour in higher organisms can often be reduced to a few stereotyped modes of movement due to physiological limitations, but finding such modes…

Cell Behavior · Quantitative Biology 2013-08-26 Luke Tweedy , Börn Meier , Jürgen Stephan , Doris Heinrich , Robert G. Endres

We examined the changes in swimming behaviour of the bacterium Rhodobacter sphaeroides in response to stepwise changes in a nutrient (propionate), following the prestimulus motion, the initial response and the adaptation to the sustained…

Quantitative Methods · Quantitative Biology 2007-05-23 Anna A. Chernova , Judith P. Armitage , Helen L. Packer , Philip K. Maini

This paper studies a chemotaxis system where cells move in response to a chemical signal within a confined habitat. The model includes external source terms that combine local and nonlocal growth with dampening effects. The main focus is on…

Analysis of PDEs · Mathematics 2025-11-11 Rafael Diaz Fuentes , Fatma Gamze Duzgun , Silvia Frassu , Giuseppe Viglialoro