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Phylogenetic trees canonically arise as embeddings of phylogenetic networks. We recently showed that the problem of deciding if two phylogenetic networks embed the same sets of phylogenetic trees is computationally hard, \blue{in…

Combinatorics · Mathematics 2021-04-13 Janosch Doecker , Simone Linz , Charles Semple

We analyze the bit complexity of efficient algorithms for fundamental optimization problems, such as linear regression, $p$-norm regression, and linear programming (LP). State-of-the-art algorithms are iterative, and in terms of the number…

Data Structures and Algorithms · Computer Science 2023-04-06 Mehrdad Ghadiri , Richard Peng , Santosh S. Vempala

Phylogenetic networks are a generalization of phylogenetic trees to leaf-labeled directed acyclic graphs that represent ancestral relationships between species whose past includes non-tree-like events such as hybridization and horizontal…

Combinatorics · Mathematics 2021-04-13 Janosch Döcker , Simone Linz , Charles Semple

We show that two important problems that have applications in computational biology are ASP-complete, which implies that, given a solution to a problem, it is NP-complete to decide if another solution exists. We show first that a variation…

Populations and Evolution · Quantitative Biology 2015-03-17 Maria Luisa Bonet , Simone Linz , Katherine St. John

What makes a computational problem easy (e.g., in P, that is, solvable in polynomial time) or hard (e.g., NP-hard)? This fundamental question now has a satisfactory answer for a quite broad class of computational problems, so called…

Computational Complexity · Computer Science 2019-09-12 Libor Barto

Tree Containment is a fundamental problem in phylogenetics useful for verifying a proposed phylogenetic network, representing the evolutionary history of certain species. Tree Containment asks whether the given phylogenetic tree (for…

Populations and Evolution · Quantitative Biology 2024-06-14 Arkadiy Dushatskiy , Esther Julien , Leen Stougie , Leo van Iersel

Phylogenetic (evolutionary) trees and networks are leaf-labeled graphs that are widely used to represent the evolutionary relationships between entities such as species, languages, cancer cells, and viruses. To reconstruct and analyze…

Data Structures and Algorithms · Computer Science 2023-08-21 Michael J. Dinneen , Pankaj S. Ghodla , Simone Linz

We consider the NP-hard Tree Containment problem that has important applications in phylogenetics. The problem asks if a given leaf-labeled network contains a subdivision of a given leaf-labeled tree. We develop a fast algorithm for the…

Computational Complexity · Computer Science 2017-02-22 Mathias Weller

Attempting to recognize a tree inside a phylogenetic network is a fundamental undertaking in evolutionary analysis. In the last few years, therefore, tree-based phylogenetic networks, which are defined by a spanning tree called a…

Combinatorics · Mathematics 2020-09-29 Momoko Hayamizu

Rooted phylogenetic networks are often used to represent conflicting phylogenetic signals. Given a set of clusters, a network is said to represent these clusters in the "softwired" sense if, for each cluster in the input set, at least one…

Populations and Evolution · Quantitative Biology 2011-03-10 Steven Kelk , Celine Scornavacca , Leo van Iersel

Deciding whether a graph can be embedded in a grid using only unit-length edges is NP-complete, even when restricted to binary trees. However, it is not difficult to devise a number of graph classes for which the problem is polynomial, even…

Data Structures and Algorithms · Computer Science 2012-04-13 Vinícius G. P. de Sá , Guilherme D. da Fonseca , Raphael Machado , Celina M. H. de Figueiredo

Genetic and comparative genomic studies indicate that extant genomes are more properly considered to be a fusion product of random mutations over generations and genomic material transfers between individuals of different lineages. This has…

Quantitative Methods · Quantitative Biology 2018-01-16 Andreas D. M. Gunawan , Bingxin Lu , Louxin Zhang

Tree containment problem is a fundamental problem in phylogenetic study, as it is used to verify a network model. It asks whether a given network contain a subtree that resembles a binary tree. The problem is NP-complete in general, even in…

Populations and Evolution · Quantitative Biology 2017-02-15 Andreas Gunawan

Comparative analyses of phylogenetic trees typically require identical taxon sets, however, in practice, trees often include distinct but overlapping taxa. Pruning non-shared leaves discards phylogenetic signal, whereas tree completion can…

Populations and Evolution · Quantitative Biology 2026-04-28 Aleksandr Koshkarov , Nadia Tahiri

A chief problem in phylogenetics and database theory is the computation of a maximum consistent tree from a set of rooted or unrooted trees. A standard input are triplets, rooted binary trees on three leaves, or quartets, unrooted binary…

Discrete Mathematics · Computer Science 2010-05-31 Leo van Iersel , Matthias Mnich

Schaefer's theorem is a complexity classification result for so-called Boolean constraint satisfaction problems: it states that every Boolean constraint satisfaction problem is either contained in one out of six classes and can be solved in…

Computational Complexity · Computer Science 2015-05-19 Manuel Bodirsky , Michael Pinsker

We present a first theoretical analysis of the power of polynomial-time preprocessing for important combinatorial problems from various areas in AI. We consider problems from Constraint Satisfaction, Global Constraints, Satisfiability,…

Artificial Intelligence · Computer Science 2014-06-13 Serge Gaspers , Stefan Szeider

We prove a complexity dichotomy theorem for a class of Holant problems on planar 3-regular bipartite graphs. The complexity dichotomy states that for every weighted constraint function $f$ defining the problem (the weights can even be…

Computational Complexity · Computer Science 2023-03-30 Jin-Yi Cai , Austen Z. Fan

We study complexity of rearrangement problems in the generalized breakpoint model and settle several open questions. The model was introduced by Tannier et al. (2009) who showed that the median problem is solvable in polynomial time in the…

Discrete Mathematics · Computer Science 2013-01-11 Jakub Kovac

The maximum parsimony phylogenetic tree reconstruction problem is NP-hard, presenting a computational bottleneck for classical computing and motivating the exploration of emerging paradigms like quantum computing. To this end, we design…

Quantum Physics · Physics 2026-04-20 Jiawei Zhang , Yibo Chen , Yang Zhou , Jun-Han Huang