Related papers: Traditional aging theories: which ones are useful?
This review mainly focuses on the relation between antioxidants with cancer therapy. Antioxidants have been reported to play an essential role to reduce free radical species. Free radicals commonly cause oxidative damage which is a common…
Complex systems, in many different scientific sectors, show coarse-grain properties with simple growth laws with respect to fundamental microscopic algorithms. We propose a classification scheme of growth laws which includes human aging,…
Development combines three basic processes asymmetric --- cell division, signaling and gene regulation --- in a multitude of ways to create an overwhelming diversity of multicellular life-forms. Here, we attempt to chart this diversity…
We know that stress-factors, e.g. X-rays, have an effect on cells that is more lethal in rapid exponential growth than in stationary phase. It is this effect which makes radiotherapy effective in cancer treatment. This stress effect can be…
To explore the mechanistic relationships between ageing, frailty and mortality, we developed a computational model in which possible health attributes are represented by the nodes of a complex network. Each node can be either damaged (i.e.…
The grandmother hypothesis is the most influential account of the evolution of menopause in humans, but other theories warrant investigation. Here I use simulations to investigate two theories that ground the evolution of menopause in…
Degeneration and adaptation are two competing sides of the same coin called resilience in the progressive processes of brain aging or diseases. Degeneration accumulates during brain aging and other cerebral activities, causing structural…
Metabolic energy consumption has long been thought to play a major role in the aging process ({\it 1}). Across species, a gram of tissue on average expends about the same amount of energy during life-span ({\it 2}). Energy restriction has…
The study of immune system aging, i.e. immunosenescence, is a relatively new research topic. It deals with understanding the processes of immunodegradation that indicate signs of functionality loss possibly leading to death. Even though it…
We describe a percolation-type approach to modeling of the processes of aging and certain other properties of tissues analyzed as systems consisting of interacting cells. Tissues are considered as structures made of regular healthy,…
The problem of unicellular-multicellular transition is one of the main issues that is discussing in evolutionary biology. In [1] the fitness of a colony of cells is considered in terms of its two basic components, viability and fecundity.…
Physical aging is one of the non-equilibrium phenomena where physical properties change over time due to structural relaxation. Aging in spin glass systems has been explained by a trap model on the temperature-independent energy landscape.…
Several independent observations have suggested that catastrophe transition in microtubules is not a first-order process, as is usually assumed. Recent {\it in vitro} observations by Gardner et al.[ M. K. Gardner et al., Cell {\bf147}, 1092…
It is well established that glassy materials can undergo aging, i.e., their properties gradually change over time. There is rapidly growing evidence that dense active and living systems also exhibit many features of glassy behavior, but it…
Purpose and meaning are necessary concepts for understanding mind and culture, but appear to be absent from the physical world and are not part of the explanatory framework of the natural sciences. Understanding how meaning (in the broad…
In this paper, we address the problem of face aging: generating past or future facial images by incorporating age-related changes to the given face. Previous aging methods rely solely on human facial image datasets and are thus constrained…
Evolutionary game theory is a successful mathematical framework geared towards understanding the selective pressures that affect the evolution of the strategies of agents engaged in interactions with potential conflicts. While a…
As cell proliferation is limited due to the loss of telomere repeats in DNA of normal somatic cells during division, telomere attrition can possibly play an important role in determining the maximum life span of organisms as well as…
We present recent progress on quantitative estimation of stellar ages using ind icators such as theoretical evolutionary tracks, rotation, rotation-driven chrom ospheric and coronal activity, and lithium depletion. Our focus is on roughly…
Evolution and learning are two of the fundamental mechanisms by which life adapts in order to survive and to transcend limitations. These biological phenomena inspired successful computational methods such as evolutionary algorithms and…