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Graph Neural Networks (GNNs) are the dominant architecture for molecular machine learning, particularly for molecular property prediction and machine learning interatomic potentials (MLIPs). GNNs perform message passing on predefined graphs…

Machine Learning · Computer Science 2025-10-03 Tobias Kreiman , Yutong Bai , Fadi Atieh , Elizabeth Weaver , Eric Qu , Aditi S. Krishnapriyan

We derived an approximate non-linear interference (NLI) closed-form model (CFM), capable of handling a very broad range of optical WDM system scenarios. We tested the CFM over 8500 randomized C-band WDM systems, of which 6250 were…

Signal Processing · Electrical Eng. & Systems 2023-07-19 Mahdi Ranjbar Zefreh , Fabrizio Forghieri , Stefano Piciaccia , Pierluigi Poggiolini

Recommender systems (RS) serve as a fundamental tool for navigating the vast expanse of online information, with deep learning advancements playing an increasingly important role in improving ranking accuracy. Among these, graph neural…

Information Retrieval · Computer Science 2025-02-18 Bin Wu , Yihang Wang , Yuanhao Zeng , Jiawei Liu , Jiashu Zhao , Cheng Yang , Yawen Li , Long Xia , Dawei Yin , Chuan Shi

The generalized Gauss-Newton (GGN) approximation is often used to make practical Bayesian deep learning approaches scalable by replacing a second order derivative with a product of first order derivatives. In this paper we argue that the…

Machine Learning · Statistics 2021-02-26 Alexander Immer , Maciej Korzepa , Matthias Bauer

This paper shows that the Levenberg-Marquardt Algorithms (LMA) algorithms can be merged into the Gauss Newton Filters (GNF) to track difficult, non-linear trajectories, without divergence. The GNF discusssed in this paper is an iterative…

Adaptation and Self-Organizing Systems · Physics 2011-10-25 Roaldje Nadjiasngar , Michael Inggs

In genome-wide prediction, independence of marker allele substitution effects is typically assumed; however, since early stages of this technology it has been known that nature points to correlated effects. In statistics, graphical models…

Quantitative Methods · Quantitative Biology 2017-09-21 Carlos Alberto Martínez , Kshitij Khare , Syed Rahman , Mauricio A. Elzo

We provide a generalization of the Gaussian Kinematic Formula (GKF) in Taylor(2006) for multivariate, heterogeneous Gaussian-related fields. The fields under consideration are non-Gaussian fields built out of smooth, independent Gaussian…

Probability · Mathematics 2017-05-15 Snigdha Panigrahi , Jonathan Taylor , Sreekar Vadlamani

Quantum mechanical methods like Density Functional Theory (DFT) are used with great success alongside efficient search algorithms for studying kinetics of reactive systems. However, DFT is prohibitively expensive for large scale…

Computational Physics · Physics 2022-09-02 Mathias Schreiner , Arghya Bhowmik , Tejs Vegge , Peter Bjørn Jørgensen , Ole Winther

Explainable artificial intelligence (XAI) approaches have been increasingly applied in drug discovery to learn molecular representations and identify substructures driving property predictions. However, building end-to-end explainable…

Machine Learning · Computer Science 2026-05-29 Zanyu Shi , Yang Wang , Pathum Weerawarna , Jie Zhang , Timothy Richardson , Yijie Wang , Kun Huang

Protein-nucleic acid complexes are important for many cellular processes including the most essential function such as transcription and translation. For many protein-nucleic acid complexes, flexibility of both macromolecules has been shown…

Biomolecules · Quantitative Biology 2015-10-28 Kristopher Opron , Kelin Xia , Zachary F. Burton , Guo-Wei Wei

The recent emergence of deep learning has led to a great deal of work on designing supervised deep semantic segmentation algorithms. As in many tasks sufficient pixel-level labels are very difficult to obtain, we propose a method which…

Computer Vision and Pattern Recognition · Computer Science 2024-04-19 Matthias Schwab , Agnes Mayr , Markus Haltmeier

Physical interactions between proteins are often difficult to decipher. The aim of this paper is to present an algorithm designed to recognize binding patches and supporting structural scaffolds of interacting heterodimer protein chains…

Biomolecules · Quantitative Biology 2016-09-22 Ognjen Perišić

We propose the Gaussian Gated Linear Network (G-GLN), an extension to the recently proposed GLN family of deep neural networks. Instead of using backpropagation to learn features, GLNs have a distributed and local credit assignment…

Machine Learning · Computer Science 2020-10-22 David Budden , Adam Marblestone , Eren Sezener , Tor Lattimore , Greg Wayne , Joel Veness

Network theory has proven invaluable in unraveling complex protein interactions. Previous studies have employed statistical methods rooted in network theory, including the Gaussian graphical model, to infer networks among proteins,…

Methodology · Statistics 2026-05-07 Seungjun Ahn , Eun Jeong Oh

We introduce a novel equivariant graph neural network (GNN) architecture designed to predict the tensorial response properties of molecules. Unlike traditional frameworks that focus on regressing scalar quantities and derive tensorial…

Machine Learning · Computer Science 2025-11-11 Jean Philip Filling , Felix Post , Michael Wand , Denis Andrienko

Large-eddy simulations (LES) require closures for filtered production rates because the resolved fields do not contain all correlations that govern chemical source terms. We develop a graph neural network (GNN) that predicts filtered…

Fluid Dynamics · Physics 2026-03-23 Priyabrat Dash , Mathis Bode , Konduri Aditya

Heterogeneous molecular entities and their interactions, commonly depicted as a network, are crucial for advancing our systems-level understanding of biology. With recent advancements in high-throughput data generation and a significant…

Quantitative Methods · Quantitative Biology 2026-03-18 Kishan KC , Rui Li , Paribesh Regmi , Anne R. Haake

Graph convolutional networks (GCNs) have recently enabled a popular class of algorithms for collaborative filtering (CF). Nevertheless, the theoretical underpinnings of their empirical successes remain elusive. In this paper, we endeavor to…

Information Retrieval · Computer Science 2021-08-18 Yifei Shen , Yongji Wu , Yao Zhang , Caihua Shan , Jun Zhang , Khaled B. Letaief , Dongsheng Li

We introduce a probabilistic model with implicit norm regularization for learning nonnegative matrix factorization (NMF) that is commonly used for predicting missing values and finding hidden patterns in the data, in which the matrix…

Machine Learning · Computer Science 2022-08-23 Jun Lu , Christine P. Chai

Deep Gaussian processes (DGPs), a hierarchical composition of GP models, have successfully boosted the expressive power of their single-layer counterpart. However, it is impossible to perform exact inference in DGPs, which has motivated the…

Machine Learning · Computer Science 2021-05-27 Haibin Yu , Dapeng Liu , Yizhou Chen , Bryan Kian Hsiang Low , Patrick Jaillet