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The fundamental problem faced in quantum chemistry is the calculation of molecular properties, which are of practical importance in fields ranging from materials science to biochemistry. Within chemical precision, the total energy of a…

Quantum chemistry simulations offer a cost-effective way for computational design of BODIPY photosensitizers with potential use in photodynamic therapy (PDT). However, accurate predictions of photophysical properties, such as excitation…

Quantum simulation of molecular electronic structure is one of the most promising applications of quantum computing. However, achieving chemically accurate predictions for strongly correlated systems requires quantum phase estimation (QPE)…

Quantum Physics · Physics 2026-03-31 Shota Kanasugi , Riki Toshio , Kazunori Maruyama , Hirotaka Oshima

The complexity of the standard hierarchy of quantum chemistry methods is not invariant to the choice of representation. This work explores how the scaling of common quantum chemistry methods can be reduced using real-space, momentum-space,…

Chemical Physics · Physics 2018-02-14 Narbe Mardirossian , James D. McClain , Garnet Kin-Lic Chan

Machine learning has enabled the prediction of quantum chemical properties with high accuracy and efficiency, allowing to bypass computationally costly ab initio calculations. Instead of training on a fixed set of properties, more recent…

Due to its favorable computational efficiency time-dependent (TD) density functional theory (DFT) enables the prediction of electronic spectra in a high-throughput manner across chemical space. Its predictions, however, can be quite…

We present a novel multi-scale embedding scheme that links conventional QM/MM embedding and bootstrap embedding (BE) to allow simulations of large chemical systems on limited quantum devices. We also propose a mixed-basis BE scheme that…

Amorphous materials are coming within reach of realistic computer simulations, but new approaches are needed to fully understand their intricate atomic structures. Here, we show how machine-learning (ML)-based techniques can give new,…

Entanglement calculations in quantum field theories are extremely challenging and typically rely on the replica trick, where the problem is rephrased in a study of defects. We demonstrate that the use of deep generative models drastically…

High Energy Physics - Lattice · Physics 2025-12-15 Andrea Bulgarelli , Elia Cellini , Karl Jansen , Stefan Kühn , Alessandro Nada , Shinichi Nakajima , Kim A. Nicoli , Marco Panero

One of the grand challenges in modern theoretical chemistry is designing and implementing approximations that expedite ab initio methods without loss of accuracy. Machine learning (ML), in particular neural networks, are emerging as a…

Chemical Physics · Physics 2018-01-10 Justin S. Smith , Olexandr Isayev , Adrian E. Roitberg

The training of molecular models of quantum mechanical properties based on statistical machine learning requires large datasets which exemplify the map from chemical structure to molecular property. Intelligent a priori selection of…

Accurately treating strong electron correlation in quantum chemistry typically requires multireference wave-function methods with steep computational scaling. The recently proposed i-DMFT method promises near configuration-interaction…

Chemical Physics · Physics 2026-04-23 Paul G. Graf , Florian Matz , Lexin Ding , Julia Liebert , Markus Penz , Christian Schilling

Silicon quantum computing has the potential to revolutionize technology with capabilities to solve real-life problems that are computationally complex or even intractable for modern computers [1] by offering sufficient high quality qubits…

Mesoscale and Nanoscale Physics · Physics 2024-09-24 Dylan H. Liang , MengKe Feng , Philip Y. Mai , Jesus D. Cifuentes , Andrew S. Dzurak , Andre Saraiva

We train convolutional neural networks to predict whether or not a set of measurements is informationally complete to uniquely reconstruct any given quantum state with no prior information. In addition, we perform fidelity benchmarking…

We present results and discuss methods for computing the melting temperature of dense molecular hydrogen using a machine learned model trained on quantum Monte Carlo data. In this newly trained model, we emphasize the importance of accurate…

Chemical Physics · Physics 2024-11-26 Shubhang Goswami , Scott Jensen , Yubo Yang , Markus Holzmann , Carlo Pierleoni , David M. Ceperley

The quantum theory of atoms in molecules (QTAIM) gives access to well-defined local atomic energies. Due to their locality, these energies are potentially interesting in fitting atomistic machine learning models as they inform about…

Soft Condensed Matter · Physics 2024-03-04 Frank Uhlig , Samuel Tovey , Christian Holm

Melting properties are critical for designing novel materials, especially for discovering high-performance, high-melting refractory materials. Experimental measurements of these properties are extremely challenging due to their high melting…

Materials Science · Physics 2024-08-19 Li-Fang Zhu , Fritz Koermann , Qing Chen , Malin Selleby , Joerg Neugebauer , and Blazej Grabowski

The electronic charge density plays a central role in determining the behavior of matter at the atomic scale, but its computational evaluation requires demanding electronic-structure calculations. We introduce an atom-centered,…

Machine learning surrogate models for quantum mechanical simulations has enabled the field to efficiently and accurately study material and molecular systems. Developed models typically rely on a substantial amount of data to make reliable…

Computational Physics · Physics 2020-12-10 Muhammed Shuaibi , Saurabh Sivakumar , Rui Qi Chen , Zachary W. Ulissi

The restricted Boltzmann machine (RBM) has been successfully applied to solve the many-electron Schr$\ddot{\text{o}}$dinger equation. In this work we propose a single-layer fully connected neural network adapted from RBM and apply it to…

Quantum Physics · Physics 2023-01-11 Yangjun Wu , Xiansong Xu , Dario Poletti , Yi Fan , Chu Guo , Honghui Shang
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