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Our brain functions as a complex communication network, and studying it from a network perspective offers valuable insights into its organizational principles and links to cognitive functions and brain disorders. However, most current…

Neurons and Cognition · Quantitative Biology 2026-01-21 Chao Cao , Tong Chen , Nan Zhao , Minheng Chen , Michael Qu , Zeyu Zhang , Xiao Shi , Xiang Li , Tianming Liu , Lu Zhang

How do different brains create unique visual experiences from identical sensory input? While neural representations vary across individuals, the fundamental architecture underlying these differences remains poorly understood. Here, we…

Neurons and Cognition · Quantitative Biology 2026-02-05 Chihye Han , Michael F. Bonner

During morphogenesis, a featureless convex cerebellum develops folds. As it does so, the cortex thickness is thinnest at the crest (gyri) and thickest at the trough (sulci) of the folds. This observation cannot be simply explained by…

Soft Condensed Matter · Physics 2021-12-24 M. C. Gandikota , J. M. Schwarz

Recent cellular-level volumetric brain reconstructions have revealed high levels of anatomic complexity. Determining which structural aspects of the brain to focus on, especially when comparing with computational models and other organisms,…

Disordered Systems and Neural Networks · Physics 2023-09-29 Helen S. Ansell , István A. Kovács

Sulci are localized furrows on the surface of soft materials that form by a compression-induced instability. We unfold this instability by breaking its natural scale and translation invariance, and compute a limiting bifurcation diagram for…

Soft Condensed Matter · Physics 2011-03-14 Evan Hohlfeld , L. Mahadevan

Current connectivity diagrams of human brain image data are either overly complex or overly simplistic. In this work we introduce simple yet accurate interactive visual representations of multiple brain image structures and the connectivity…

Graphics · Computer Science 2016-09-02 Saad Nadeem , Arie Kaufman

We investigate experimentally and model theoretically the mechanical behaviour of brain matter in torsion. Using a strain-controlled rheometer we perform torsion tests on fresh porcine brain samples. We quantify the torque and the normal…

Soft Condensed Matter · Physics 2020-01-06 Valentina Balbi , Antonia Trotta , Michel Destrade , Aisling Ní Annaidh

At large, most animal brains present two mirror-symmetric sides; but closer inspection reveals a range of asymmetries (in shape and function), that seem more salient in more cognitively complex species. Sustaining symmetric, redundant…

Neurons and Cognition · Quantitative Biology 2021-12-02 Luís F Seoane

The origin of rigidity in disordered materials is an outstanding open problem in statistical physics. Previously, a class of 2D cellular models has been shown to undergo a rigidity transition controlled by a mechanical parameter that…

Soft Condensed Matter · Physics 2023-01-18 Matthias Merkel , Lisa Manning

In this study we give a geometrical model which employs the smoothness of nerve fibers as differentiable curves. We show that a nerve fiber may encounter large curvature due to the possible helicial bending and hence it could cause the…

General Physics · Physics 2019-03-27 S. Habib Mazharimousavi , M. Halilsoy

Mammalian brains span about 4 orders of magnitude in cortical volume and have to operate in different environments that require diverse behavioral skills. Despite these geometric and behavioral diversities, the examination of cerebral…

Neurons and Cognition · Quantitative Biology 2014-05-19 Jan Karbowski

We review, systematize and discuss models of diffusion in neuronal tissue, by putting them into an overarching physical context of coarse-graining over an increasing diffusion length scale. From this perspective, we view research on…

Biological Physics · Physics 2018-04-20 Dmitry S. Novikov , Els Fieremans , Sune N. Jespersen , Valerij G. Kiselev

The cerebral cortex displays a bewildering diversity of shapes and sizes across and within species. Despite this diversity, we present a universal multi-scale description of primate cortices. We show that all cortical shapes can be…

Compression stiffening, or an increase in shear modulus with increasing compressive strain, has been observed in recent rheometry experiments on brain, liver, and fat tissues. Here, we extend the known types of biomaterials exhibiting this…

Soft Condensed Matter · Physics 2019-06-05 T. A. Engstrom , K. Pogoda , K. Cruz , P. A. Janmey , J. M. Schwarz

Background: Information processing in the brain requires large amounts of metabolic energy, the spatial distribution of which is highly heterogeneous reflecting complex activity patterns in the mammalian brain. Results: Here, it is found…

Neurons and Cognition · Quantitative Biology 2007-05-23 Jan Karbowski

It is known that the biological activity of the brain involves radiation of electric waves. These waves result from ionic currents and charges traveling among the brain's neurons. But it is obvious that these ions and charges are carried by…

General Relativity and Quantum Cosmology · Physics 2007-08-14 D. Bar

Grain growth in polycrystals is traditionally considered a capillarity-driven process, where grain boundaries (GBs) migrate toward their centers of curvature (i.e., mean curvature flow) with a velocity proportional to the local curvature…

Materials Science · Physics 2025-09-12 Caihao Qiu , David J. Srolovitz , Gregory S. Rohrer , Jian Han , Marco Salvalaglio

As an injury heals, an embryo develops, or a carcinoma spreads, epithelial cells systematically change their shape. In each of these processes cell shape is studied extensively, whereas variation of shape from cell-to-cell is dismissed most…

The human brain forms functional networks on all spatial scales. Modern fMRI scanners allow to resolve functional brain data in high resolutions, allowing to study large-scale networks that relate to cognitive processes. The analysis of…

Neurons and Cognition · Quantitative Biology 2019-05-14 Melanie Weber , Johannes Stelzer , Emil Saucan , Alexander Naitsat , Gabriele Lohmann , Jürgen Jost

Spiral waves are ubiquitous signatures of non equilibrium dynamics, appearing across chemical, biological, and active systems. Yet, in many living systems these waves unfold on curved and folded surfaces whose geometry has rarely been…

Soft Condensed Matter · Physics 2026-01-19 Varun Venkatesh , Farzan Vafa , Martin Cramer Pedersen , Amin Doostmohammadi