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Related papers: Robust generation of elementary flux modes

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We cast the metabolism of interacting cells within a statistical mechanics framework considering both, the actual phenotypic capacities of each cell and its interaction with its neighbors. Reaction fluxes will be the components of…

Molecular Networks · Quantitative Biology 2020-04-08 Jorge Fernandez-de-Cossio-Diaz , Roberto Mulet

Empirical risk minimization (ERM) is sensitive to spurious correlations in the training data, which poses a significant risk when deploying systems trained under this paradigm in high-stake applications. While the existing literature…

Machine Learning · Computer Science 2023-10-31 Christos Tsirigotis , Joao Monteiro , Pau Rodriguez , David Vazquez , Aaron Courville

Recent works have established the utility of sparsity-promoting norms for extracting spatially-localized instability mechanisms in fluid flows, with possible implications for flow control. However, these prior works have focused on linear…

Fluid Dynamics · Physics 2023-11-17 A. Leonid Heide , Maziar S. Hemati

Energy-Based Models (EBMs) have proven to be a highly effective approach for modelling densities on finite-dimensional spaces. Their ability to incorporate domain-specific choices and constraints into the structure of the model through…

Machine Learning · Computer Science 2023-02-24 Jen Ning Lim , Sebastian Vollmer , Lorenz Wolf , Andrew Duncan

We propose a novel polyhedral uncertainty set for robust optimization, termed the smooth uncertainty set, which captures dependencies of uncertain parameters by constraining their pairwise differences. The bounds on these differences may be…

Optimization and Control · Mathematics 2025-10-13 Noam Goldberg , Michael Poss , Shimrit Shtern

The so-called matrix-element method (MEM) has long been used successfully as a classification tool in particle physics searches. In the presence of invisible final state particles, the traditional MEM typically assigns probabilities to an…

High Energy Physics - Phenomenology · Physics 2019-08-26 Stefan von Buddenbrock , Olivier Mattelaer , Michael Spannowsky

Background: Genome-scale metabolic network models and constraint-based modeling techniques have become important tools for analyzing cellular metabolism. Thermodynamically infeasible cy-cles (TICs) causing unbounded metabolic flux ranges…

Molecular Networks · Quantitative Biology 2017-11-15 Siu Hung Joshua Chan , Lin Wang , Satyakam Dash , Costas D. Maranas

Standard maximum likelihood or Bayesian approaches to parameter estimation for stochastic differential equations are not robust to perturbations in the continuous-in-time data. In this paper, we give a rather elementary explanation of this…

Numerical Analysis · Mathematics 2023-12-20 Sebastian Reich

We consider robust submodular maximization problems (RSMs), where given a set of $m$ monotone submodular objective functions, the robustness is with respect to the worst-case (scaled) objective function. The model we consider generalizes…

Optimization and Control · Mathematics 2023-06-12 Hsin-Yi Huang , Hao-Hsiang Wu , Simge Kucukyavuz

Accurate prediction of energy and forces for 3D molecular systems is one of fundamental challenges at the core of AI for Science applications. Many powerful and data-efficient neural networks predict molecular energies and forces from…

Chemical Physics · Physics 2026-04-23 Ali Mollahosseini , Mohammed Haroon Dupty , Wee Sun Lee

Production of chemicals from engineered organisms in a batch culture involves an inherent trade-off between productivity, yield, and titer. Existing strategies for strain design typically focus on designing mutations that achieve the…

Quantitative Methods · Quantitative Biology 2016-10-05 Peter C. St. John , Michael F. Crowley , Yannick J. Bomble

While denoising diffusion and flow matching have driven major advances in generative modeling, their application to tabular data remains limited, despite its ubiquity in real-world applications. To this end, we develop TabbyFlow, a…

Machine Learning · Computer Science 2025-10-06 Andrés Guzmán-Cordero , Floor Eijkelboom , Jan-Willem van de Meent

As a vital aspect of affective computing, Multimodal Emotion Recognition has been an active research area in the multimedia community. Despite recent progress, this field still confronts two major challenges in real-world applications: 1)…

Computer Vision and Pattern Recognition · Computer Science 2023-12-27 Chengxin Chen , Pengyuan Zhang

This paper addresses the transmission network expansion planning problem considering storage units under uncertain demand and generation capacity. A two-stage adaptive robust optimization framework is adopted whereby short- and long-term…

Optimization and Control · Mathematics 2021-01-19 Álvaro García-Cerezo , Luis Baringo , Raquel García-Bertrand

Multimodal data collected from the real world are often imperfect due to missing modalities. Therefore multimodal models that are robust against modal-incomplete data are highly preferred. Recently, Transformer models have shown great…

Computer Vision and Pattern Recognition · Computer Science 2022-04-13 Mengmeng Ma , Jian Ren , Long Zhao , Davide Testuggine , Xi Peng

Electrospray tandem mass spectrometry (ESI-MS/MS) is commonly used in high throughput metabolomics. One of the key obstacles to the effective use of this technology is the difficulty in interpreting measured spectra to accurately and…

Computational Engineering, Finance, and Science · Computer Science 2014-06-10 F. Allen , R. Greiner , D. Wishart

Neural network models have become the leading solution for a large variety of tasks, such as classification, language processing, protein folding, and others. However, their reliability is heavily plagued by adversarial inputs: small input…

Machine Learning · Computer Science 2022-10-04 Natan Levy , Guy Katz

We consider a linearly elastic composite medium, which consists of a homogeneous matrix containing a statistically homogeneous set of multimodal spherical inclusions modeling the morphology of heterogeneous solid propellants (HSP).…

Materials Science · Physics 2012-09-21 V. A. Buryachenko

In this work we study binary classification problems where we assume that our training data is subject to uncertainty, i.e. the precise data points are not known. To tackle this issue in the field of robust machine learning the aim is to…

Machine Learning · Computer Science 2022-03-04 Jannis Kurtz

The inverse design of metasurfaces faces inherent challenges due to the nonlinear and highly complex relationship between geometric configurations and their electromagnetic behavior. Traditional optimization approaches often suffer from…

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