English
Related papers

Related papers: A generative model for protein contact networks

200 papers

Mechanistic network models specify the mechanisms by which networks grow and change, allowing researchers to investigate complex systems using both simulation and analytical techniques. Unfortunately, it is difficult to write likelihoods…

Methodology · Statistics 2023-07-19 Jonathan Larson , Jukka-Pekka Onnela

We propose a growing network model that consists of two tunable mechanisms: growth by merging modules which are represented as complete graphs and a fitness-driven preferential attachment. Our model exhibits the three prominent statistical…

Molecular Networks · Quantitative Biology 2007-07-31 Kazuhiro Takemoto , Chikoo Oosawa

Robust and efficient design of networks on a realistic geographical space is one of the important issues for the realization of dependable communication systems. In this paper, based on a percolation theory and a geometric graph property,…

Data Analysis, Statistics and Probability · Physics 2011-11-04 Yukio Hayashi

We introduce a principled generative framework for graph signals that enables explicit control of feature heterophily, a key property underlying the effectiveness of graph learning methods. Our model combines a Lipschitz graphon-based…

Machine Learning · Statistics 2025-09-30 Haoyu Wang , Renyuan Ma , Gonzalo Mateos , Luana Ruiz

We propose a structure-preserving model-reduction methodology for large-scale dynamic networks with tightly-connected components. First, the coherent groups are identified by a spectral clustering algorithm on the graph Laplacian matrix…

Systems and Control · Electrical Eng. & Systems 2023-05-15 Hancheng Min , Enrique Mallada

Proteins are the basic building blocks of life. They usually perform functions by folding to a particular structure. Understanding the folding process could help the researchers to understand the functions of proteins and could also help to…

Computational Engineering, Finance, and Science · Computer Science 2015-10-21 Jianzhu Ma

Graphs with diverse structural characteristics play a central role in modelling and optimization tasks. The ability to generate different types of graphs that exhibit shared properties is likewise essential for algorithm selection and…

Neural and Evolutionary Computing · Computer Science 2026-03-31 Hendrik Richter , Frank Neumann

Recent years have seen tremendous growth of many online social networks such as Facebook, LinkedIn and MySpace. People connect to each other through these networks forming large social communities providing researchers rich datasets to…

Social and Information Networks · Computer Science 2017-02-07 Muhammad Qasim Pasta , Faraz Zaidi , Céline Rozenblat

Network theorists have developed methods to characterize the complex interactions in natural phenomena. The structure of the network of interactions between proteins is important in the field of proteomics, and has been subject to intensive…

Molecular Networks · Quantitative Biology 2016-09-07 Allan A. Zea , Antonio Rueda-Toicen

Graph neural networks (GNNs) have emerged as powerful tools for learning protein structures by capturing spatial relationships at the residue level. However, existing GNN-based methods often face challenges in learning multiscale…

Machine Learning · Computer Science 2026-02-03 Shih-Hsin Wang , Yuhao Huang , Taos Transue , Justin Baker , Jonathan Forstater , Thomas Strohmer , Bao Wang

Tuning curves characterizing the response selectivities of biological neurons often exhibit large degrees of irregularity and diversity across neurons. Theoretical network models that feature heterogeneous cell populations or random…

Quantitative Methods · Quantitative Biology 2017-07-20 Takafumi Arakaki , G. Barello , Yashar Ahmadian

Community detection is considered as a fundamental task in analyzing social networks. Even though many techniques have been proposed for community detection, most of them are based exclusively on the connectivity structures. However, there…

Social and Information Networks · Computer Science 2019-12-25 Hadi Zare , Mahdi Hajiabadi , Mahdi Jalili

Complex networks theory has commonly been used for modelling and understanding the interactions taking place between the elements composing complex systems. More recently, the use of generative models has gained momentum, as they allow…

Physics and Society · Physics 2016-05-19 Massimiliano Zanin , Marco Correia , Pedro A. C. Sousa , Jorge Cruz

Protein contacts provide key information for the understanding of protein structure and function, and therefore contact prediction from sequences is an important problem. Recent research shows that some correctly predicted long-range…

Quantitative Methods · Quantitative Biology 2020-09-02 Siqi Sun

This paper presents the foundation for a decomposition theory for Boolean networks, a type of discrete dynamical system that has found a wide range of applications in the life sciences, engineering, and physics. Given a Boolean network…

Dynamical Systems · Mathematics 2022-06-10 Claus Kadelka , Reinhard Laubenbacher , David Murrugarra , Alan Veliz-Cuba , Matthew Wheeler

Mean field theory models of percolation on networks provide analytic estimates of network robustness under node or edge removal. We introduce a new mean field theory model based on generating functions that includes information about the…

Physics and Society · Physics 2023-08-01 Chris Jones , Karoline Wiesner

The ability to computationally generate novel yet physically foldable protein structures could lead to new biological discoveries and new treatments targeting yet incurable diseases. Despite recent advances in protein structure prediction,…

Biomolecules · Quantitative Biology 2022-11-28 Kevin E. Wu , Kevin K. Yang , Rianne van den Berg , James Y. Zou , Alex X. Lu , Ava P. Amini

Network neuroscience is the emerging discipline concerned with investigating the complex patterns of interconnections found in neural systems, and to identify principles with which to understand them. Within this discipline, one…

Neurons and Cognition · Quantitative Biology 2017-08-29 Richard F. Betzel , Danielle S. Bassett

An efficient structural identifiability analysis algorithm is developed in this study for a broad range of network structures. The proposed method adopts the Wright's path coefficient method to generate identifiability equations in forms of…

Molecular Networks · Quantitative Biology 2017-08-25 Yulin Wang , Na Lu , Hongyu Miao

We study structure, eigenvalue spectra and diffusion dynamics in a wide class of networks with subgraphs (modules) at mesoscopic scale. The networks are grown within the model with three parameters controlling the number of modules, their…

Statistical Mechanics · Physics 2009-08-25 Marija Mitrović , Bosiljka Tadić