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Standard approaches to analysing data in genome-wide association studies (GWAS) ignore any potential functional relationships between genetic markers. In contrast gene pathways analysis uses prior information on functional structure within…

Methodology · Statistics 2013-02-26 M. Silver , P. Chen , L. Ruoying , C. Y. Cheng , T. Y. Wong , E. Tai , Y. Y. Teo , G. Montana

Real-world relations among entities can often be observed and determined by different perspectives/views. For example, the decision made by a user on whether to adopt an item relies on multiple aspects such as the contextual information of…

Machine Learning · Computer Science 2018-02-16 Chun-Ta Lu , Lifang He , Hao Ding , Bokai Cao , Philip S. Yu

Discovering genes with similar functions across diverse biomedical contexts poses a significant challenge in gene representation learning due to data heterogeneity. In this study, we resolve this problem by introducing a novel model called…

Machine Learning · Computer Science 2023-10-05 Tianyu Liu , Yuge Wang , Rex Ying , Hongyu Zhao

Tailoring treatment assignment to specific individuals can improve the health outcomes, but a single study may offer inadequate information for this purpose. The ability to leverage information from an auxiliary data source deemed to be…

Methodology · Statistics 2025-02-05 Ashwini Venkatasubramaniam , Julian Wolfson

In this paper, we present a new variable selection method for regression and classification purposes. Our method, called Subsampling Ranking Forward selection (SuRF), is based on LASSO penalised regression, subsampling and forward-selection…

Methodology · Statistics 2021-05-25 Lihui Liu , Hong Gu , Johan Van Limbergen , Toby Kenney

The relationships between objects in a network are typically diverse and complex, leading to the heterogeneous edges with different semantic information. In this paper, we focus on exploring the heterogeneous edges for network…

Social and Information Networks · Computer Science 2021-10-22 Hong Huang , Yu Song , Fanghua Ye , Xing Xie , Xuanhua Shi , Hai Jin

We propose a unified framework to speed up the existing stochastic matrix factorization (SMF) algorithms via variance reduction. Our framework is general and it subsumes several well-known SMF formulations in the literature. We perform a…

Machine Learning · Statistics 2017-05-23 Renbo Zhao , William B. Haskell , Jiashi Feng

Despite significant progress, previous multi-view unsupervised feature selection methods mostly suffer from two limitations. First, they generally utilize either cluster structure or similarity structure to guide the feature selection,…

Computer Vision and Pattern Recognition · Computer Science 2023-08-14 Si-Guo Fang , Dong Huang , Chang-Dong Wang , Yong Tang

Hyperspectral unmixing aims at estimating material signatures (known as endmembers) and the corresponding proportions (referred to abundances), which is a critical preprocessing step in various hyperspectral imagery applications. This study…

Computer Vision and Pattern Recognition · Computer Science 2025-08-06 Gang Yang

Single-cell gene expression data are often characterized by large matrices, where the number of cells may be lower than the number of genes of interest. Factorization models have emerged as powerful tools to condense the available…

Methodology · Statistics 2023-05-22 Antonio Canale , Luisa Galtarossa , Davide Risso , Lorenzo Schiavon , Giovanni Toto

We present Supervised Deep Multimodal Matrix Factorization (SD3MF), an interpretable framework for integrative brain network analysis that generalizes Symmetric Nonnegative Matrix Tri-Factorization (SNMTF) from unsupervised single-graph…

Machine Learning · Computer Science 2026-05-14 Amjad Seyedi , Lifang He , Songlin Zhao , Akwum Onwunta , Nicolas Gillis

This paper presents a new modeling strategy for joint unsupervised analysis of multiple high-throughput biological studies. As in Multi-study Factor Analysis, our goals are to identify both common factors shared across studies and…

Applications · Statistics 2018-06-27 Roberta De Vito , Ruggero Bellio , Lorenzo Trippa , Giovanni Parmigiani

Bayesian Non-negative Matrix Factorization (NMF) is a promising approach for understanding uncertainty and structure in matrix data. However, a large volume of applied work optimizes traditional non-Bayesian NMF objectives that fail to…

Machine Learning · Statistics 2018-03-19 M. Arjumand Masood , Finale Doshi-Velez

Factor analysis provides a canonical framework for imposing lower-dimensional structure such as sparse covariance in high-dimensional data. High-dimensional data on the same set of variables are often collected under different conditions,…

Methodology · Statistics 2024-08-27 Noirrit Kiran Chandra , David B. Dunson , Jason Xu

We develop a feature allocation model for inference on genetic tumor variation using next-generation sequencing data. Specifically, we record single nucleotide variants (SNVs) based on short reads mapped to human reference genome and…

Applications · Statistics 2015-09-15 Juhee Lee , Peter Müller , Kamalakar Gulukota , Yuan Ji

Learning by integrating multiple heterogeneous data sources is a common requirement in many tasks. Collective Matrix Factorization (CMF) is a technique to learn shared latent representations from arbitrary collections of matrices. It can be…

Machine Learning · Computer Science 2021-09-29 Ragunathan Mariappan , Vaibhav Rajan

Software fault prediction (SFP) is a critical task in software engineering, enabling early identification of faults in modules to improve software quality and reduce maintenance costs. This research investigates the combined effects of…

Software Engineering · Computer Science 2026-05-19 Ahmad Nauman Ghazi , Nagajyothi Devarapalli , Ashir Javeed , Sadi Alawadi , Fahed Alkhabbas , Khalid AlKharabsheh

Gene expression datasets are usually of high dimensionality and therefore require efficient and effective methods for identifying the relative importance of their attributes. Due to the huge size of the search space of the possible…

Machine Learning · Computer Science 2022-06-10 Fernando Jiménez , Gracia Sánchez , José Palma , Luis Miralles-Pechuán , Juan Botía

Feature selection is a widely used dimension reduction technique to select feature subsets because of its interpretability. Many methods have been proposed and achieved good results, in which the relationships between adjacent data points…

Machine Learning · Computer Science 2020-06-01 Yan Min , Mao Ye , Liang Tian , Yulin Jian , Ce Zhu , Shangming Yang

Spatial transcriptomics enables genome-wide expression analysis within native tissue context, yet identifying spatial domains remains challenging due to complex gene-spatial interactions. Existing methods typically process spatial and…

Machine Learning · Computer Science 2025-12-19 Jianping Mei , Siqi Ai , Ye Yuan