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Latent Markov (LM) models represent an important class of models for the analysis of longitudinal data (Bartolucci et. al., 2013), especially when response variables are categorical. These models have a great potential of application for…

Computation · Statistics 2015-01-20 Francesco Bartolucci , Alessio Farcomeni , Silvia Pandolfi , Fulvia Pennoni

We describe the \proglang{R} package \pkg{glmmrBase} and an extension \pkg{glmmrOptim}. \pkg{glmmrBase} provides a flexible approach to specifying, fitting, and analysing generalised linear mixed models. We use an object-orientated class…

Computation · Statistics 2024-03-15 Samuel I. Watson

The analysis of longitudinal data gives the chance to observe how unit behaviors change over time, but it also poses a series of issues. These have been the focus of an extensive literature in the context of linear and generalized linear…

Computation · Statistics 2025-10-20 Marco Alfó , Maria Francesca Marino , Maria Giovanna Ranalli , Nicola Salvati

ProfileGLMM is an R package integrating Generalised Linear Mixed Models (GLMMs) as the outcome model for Bayesian profile regression. This statistical framework simultaneously i) explains the variation in the outcome and ii) clusters the…

Methodology · Statistics 2026-04-23 Matteo Amestoy , Mark A. van de Wiel , Wessel N. van Wieringen

The R package trajmsm provides functions designed to simplify the estimation of the parameters of a model combining latent class growth analysis (LCGA), a trajectory analysis technique, and marginal structural models (MSMs) called LCGA-MSM.…

The R package merlin performs flexible joint modelling of hierarchical multi-outcome data. Increasingly, multiple longitudinal biomarker measurements, possibly censored time-to-event outcomes and baseline characteristics are available.…

Computation · Statistics 2020-07-29 Emma C. Martin , Alessandro Gasparini , Michael J. Crowther

We introduce the R package nlpsem, a comprehensive toolkit for analyzing longitudinal processes within the structural equation modeling (SEM) framework, incorporating individual measurement occasions. This package emphasizes nonlinear…

Methodology · Statistics 2025-12-02 Jin Liu

This contribution presents a guide to the R package multilevLCA, which offers a complete and innovative set of technical tools for the latent class analysis of single-level and multilevel categorical data. We describe the available model…

Computation · Statistics 2024-04-11 Johan Lyrvall , Roberto Di Mari , Zsuzsa Bakk , Jennifer Oser , Jouni Kuha

Sequence analysis is being more and more widely used for the analysis of social sequences and other multivariate categorical time series data. However, it is often complex to describe, visualize, and compare large sequence data, especially…

Computation · Statistics 2021-03-22 Satu Helske , Jouni Helske

This paper describes and illustrates the functionality of the baker R package. The package estimates a suite of nested partially-latent class models (NPLCM) for multivariate binary responses that are observed under a case-control design.…

Methodology · Statistics 2022-02-25 Irena B Chen , Qiyuan Shi , Scott L Zeger , Zhenke Wu

Joint models for longitudinal and time-to-event data constitute an attractive modeling framework that has received a lot of interest in the recent years. This paper presents the capabilities of the R package JMbayes for fitting these models…

Computation · Statistics 2014-05-01 Dimitris Rizopoulos

Datasets that exhibit non-Gaussian characteristics are common in many fields, while the current modeling framework and available software for non-Gaussian models is limited. We introduce Linear Latent Non-Gaussian Models (LLnGMs), a unified…

Methodology · Statistics 2026-03-02 David Bolin , Xiaotian Jin , Alexandre B. Simas , Jonas Wallin

Maximum likelihood or restricted maximum likelihood (REML) estimates of the parameters in linear mixed-effects models can be determined using the lmer function in the lme4 package for R. As for most model-fitting functions in R, the model…

Computation · Statistics 2014-06-24 Douglas Bates , Martin Mächler , Ben Bolker , Steve Walker

Correlation among the observations in high-dimensional regression modeling can be a major source of confounding. We present a new open-source package, plmmr, to implement penalized linear mixed models in R. This R package estimates…

Computation · Statistics 2026-05-13 Tabitha K. Peter , Anna C. Reisetter , Yujing Lu , Oscar A. Rysavy , Patrick J. Breheny

This paper introduces the R package INLAjoint, designed as a toolbox for fitting a diverse range of regression models addressing both longitudinal and survival outcomes. INLAjoint relies on the computational efficiency of the integrated…

Methodology · Statistics 2024-04-04 Denis Rustand , Janet van Niekerk , Elias Teixeira Krainski , Håvard Rue

Generalized linear mixed models (GLMMs) are widely used in research for their ability to model correlated outcomes with non-Gaussian conditional distributions. The proper selection of fixed and random effects is a critical part of the…

Computation · Statistics 2024-04-18 Hillary M. Heiling , Naim U. Rashid , Quefeng Li , Joseph G. Ibrahim

We present generalized additive latent and mixed models (GALAMMs) for analysis of clustered data with responses and latent variables depending smoothly on observed variables. A scalable maximum likelihood estimation algorithm is proposed,…

Methodology · Statistics 2023-03-29 Øystein Sørensen , Anders M. Fjell , Kristine B. Walhovd

We introduce the BMRMM package implementing Bayesian inference for a class of Markov renewal mixed models which can characterize the stochastic dynamics of a collection of sequences, each comprising alternative instances of categorical…

Methodology · Statistics 2024-09-18 Yutong Wu , Abhra Sarkar

We illustrate a class of Item Response Theory (IRT) models for binary and ordinal polythomous items and we describe an R package for dealing with these models, which is named MultiLCIRT. The models at issue extend traditional IRT models…

Applications · Statistics 2012-10-22 Francesco Bartolucci , Silvia Bacci , Michela Gnaldi

The matched case-control design, up until recently mostly pertinent to epidemiological studies, is becoming customary in biomedical applications as well. For instance, in omics studies, it is quite common to compare cancer and healthy…

Methodology · Statistics 2024-02-05 Vera Djordjilović , Erica Ponzi , Therese Haugdahl Nøst , Magne Thoresen
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