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The computer-aided detection (CADe) systems are developed to assist pathologists in slide assessment, increasing diagnosis efficiency and reducing missing inspections. Many studies have shown such a CADe system with deep learning approaches…

Computer Vision and Pattern Recognition · Computer Science 2019-03-05 Wei-Wen Hsu , Chung-Hao Chen , Chang Hoa , Yu-Ling Hou , Xiang Gao , Yun Shao , Xueli Zhang , Jingjing Wang , Tao He , Yanghong Tai

We explore the problem of Incremental Generalized Category Discovery (IGCD). This is a challenging category incremental learning setting where the goal is to develop models that can correctly categorize images from previously seen…

Computer Vision and Pattern Recognition · Computer Science 2023-12-11 Bingchen Zhao , Oisin Mac Aodha

In this paper, we study the problem of non-adaptive group testing, in which one seeks to identify which items are defective given a set of suitably-designed tests whose outcomes indicate whether or not at least one defective item was…

Information Theory · Computer Science 2025-09-26 Lan V. Truong , Matthew Aldridge , Jonathan Scarlett

Heterogeneity is a hallmark of complex diseases. Regression-based heterogeneity analysis, which is directly concerned with outcome-feature relationships, has led to a deeper understanding of disease biology. Such an analysis identifies the…

Methodology · Statistics 2022-11-29 Ziye Luo , Xinyue Yao , Yifan Sun , Xinyan Fan

Antibodies are versatile proteins that bind to pathogens like viruses and stimulate the adaptive immune system. The specificity of antibody binding is determined by complementarity-determining regions (CDRs) at the tips of these Y-shaped…

Biomolecules · Quantitative Biology 2022-01-31 Wengong Jin , Jeremy Wohlwend , Regina Barzilay , Tommi Jaakkola

Although deep learning can provide promising results in medical image analysis, the lack of very large annotated datasets confines its full potential. Furthermore, limited positive samples also create unbalanced datasets which limit the…

Computer Vision and Pattern Recognition · Computer Science 2018-05-09 Ken C. L. Wong , Alexandros Karargyris , Tanveer Syeda-Mahmood , Mehdi Moradi

The International Classification of Diseases (ICD) serves as a definitive medical classification system encompassing a wide range of diseases and conditions. The primary objective of ICD indexing is to allocate a subset of ICD codes to a…

Computation and Language · Computer Science 2024-05-30 Xindi Wang , Robert E. Mercer , Frank Rudzicz

We consider the problem of designing an adaptive sequence of questions that optimally classify a candidate's ability into one of several categories or discriminative grades. A candidate's ability is modeled as an unknown parameter, which,…

Machine Learning · Computer Science 2020-04-14 Achal Bassamboo , Vikas Deep , Sandeep Juneja , Assaf Zeevi

Imaging-derived phenotypes (IDPs) summarize multi-organ physiology but provide only static snapshots of diseases that evolve over time. In contrast, longitudinal electronic health records encode disease trajectories through temporal…

Information Retrieval · Computer Science 2026-05-13 Zian Wang , Lizhen Lan , Guangming Wang , Haosen Zhang , Minxuan Xu , Qing Li , Tianxing He , Mo Yang , Wenyue Mao , Yajing Zhang , Yan Li , Chengyan Wang

Label distribution learning (LDL) is a novel paradigm that describe the samples by label distribution of a sample. However, acquiring LDL dataset is costly and time-consuming, which leads to the birth of incomplete label distribution…

Machine Learning · Computer Science 2025-11-18 Jiecheng Jiang , Jiawei Tang , Jiahao Jiang , Hui Liu , Junhui Hou , Yuheng Jia

In this paper we present an elaborated graph-based algorithmic technique for efficient malware detection. More precisely, we utilize the system-call dependency graphs (or, for short ScD graphs), obtained by capturing taint analysis traces…

Cryptography and Security · Computer Science 2014-12-31 Stavros D. Nikolopoulos , Iosif Polenakis

A common starting point for drug design is to find small chemical groups or "fragments" that form interactions with distinct subregions in a protein binding pocket. The subsequent challenge is to assemble these fragments into a molecule…

Quantitative Methods · Quantitative Biology 2025-05-29 Rohan V. Koodli , Alexander S. Powers , Ayush Pandit , Chiho Im , Ron O. Dror

Predicting genetic mutations from whole slide images is indispensable for cancer diagnosis. However, existing work training multiple binary classification models faces two challenges: (a) Training multiple binary classifiers is inefficient…

Computer Vision and Pattern Recognition · Computer Science 2024-06-06 Gexin Huang , Chenfei Wu , Mingjie Li , Xiaojun Chang , Ling Chen , Ying Sun , Shen Zhao , Xiaodan Liang , Liang Lin

Infectious diseases continue to pose a serious threat to public health, underscoring the urgent need for effective computational approaches to screen novel anti-infective agents. Oligopeptides have emerged as promising candidates in…

Machine Learning · Computer Science 2025-09-25 Dayu Tan , Jing Chen , Xiaoping Zhou , Yansen Su , Chunhou Zheng

In this paper we present a system for the detection of immunogold particles and a Transfer Learning (TL) framework for the recognition of these immunogold particles. Immunogold particles are part of a high-magnification method for the…

Assume that a graph $G$ models a detection system for a facility with a possible "intruder," or a multiprocessor network with a possible malfunctioning processor. We consider the problem of placing (the minimum number of) detectors at a…

Discrete Mathematics · Computer Science 2022-04-26 Devin Jean , Suk Seo

Deep learning based approaches to Computer Aided Diagnosis (CAD) typically pose the problem as an image classification (Normal or Abnormal) problem. These systems achieve high to very high accuracy in specific disease detection for which…

Computer Vision and Pattern Recognition · Computer Science 2020-10-06 Aniket Joshi , Gaurav Mishra , Jayanthi Sivaswamy

Recent advances in noiseless non-adaptive group testing have led to a precise asymptotic characterization of the number of tests required for high-probability recovery in the sublinear regime $k = n^{\theta}$ (with $\theta \in (0,1)$), with…

Data Structures and Algorithms · Computer Science 2021-12-24 Oliver Gebhard , Max Hahn-Klimroth , Olaf Parczyk , Manuel Penschuck , Maurice Rolvien , Jonathan Scarlett , Nelvin Tan

Learning invariant graph representations for out-of-distribution (OOD) generalization remains challenging because the learned representations often retain spurious components. To address this challenge, this work introduces a new tool from…

Machine Learning · Computer Science 2025-12-09 Barproda Halder , Pasan Dissanayake , Sanghamitra Dutta

Despite recent success in using the invariance principle for out-of-distribution (OOD) generalization on Euclidean data (e.g., images), studies on graph data are still limited. Different from images, the complex nature of graphs poses…

Machine Learning · Computer Science 2022-10-12 Yongqiang Chen , Yonggang Zhang , Yatao Bian , Han Yang , Kaili Ma , Binghui Xie , Tongliang Liu , Bo Han , James Cheng
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