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The study's objective is to explore the distinctions in the functional brain network connectivity between Alzheimer's Disease (AD) patients and normal controls using Functional Magnetic Resonance Imaging (fMRI). The study included 590…

Neurons and Cognition · Quantitative Biology 2023-05-17 Yongcheng Yao

We analyze functional magnetic resonance imaging (fMRI) data from the Human Connectome Project (HCP) to match brain activities during a range of cognitive tasks. Our findings demonstrate that even basic linear machine learning models can…

Neurons and Cognition · Quantitative Biology 2025-10-08 Valeriya Kirova , Dzerassa Kadieva , Daniil Vlasenko , Isak B. Blank , Fedor Ratnikov

Functional connectomes capture brain interactions via synchronized fluctuations in the functional magnetic resonance imaging signal. If measured during rest, they map the intrinsic functional architecture of the brain. With task-driven…

Neurons and Cognition · Quantitative Biology 2013-04-16 Gaël Varoquaux , R. C. Craddock

Predicting brain maturity using noninvasive magnetic resonance images (MRI) can distinguish different age groups and help to assess neurodevelopmental disorders. However, group-wise differences are often less informative for assessing…

Neurons and Cognition · Quantitative Biology 2014-12-17 Cheol E. Han , Luis R. Peraza , John-Paul Taylor , Marcus Kaiser

Evaluating the functional relationships between brain regions measured with neuroimaging provides insight into how the brain is sharing information at a macro scale. Many functional connectivity methods have been developed for dynamic…

Applications · Statistics 2015-10-30 David B. Keator , Alexander Ihler

This paper presents a comprehensive and quality collection of functional human brain network data for potential research in the intersection of neuroscience, machine learning, and graph analytics. Anatomical and functional MRI images have…

Functional connectivity, as estimated using resting state fMRI, has shown potential in bridging the gap between pathophysiology and cognition. However, clinical use of functional connectivity biomarkers is impeded by unreliable estimates of…

Evaluating the causal effect of an intervention on multivariate outcomes is challenging when the outcomes are interdependent and derived rather than directly observed. Effective connectivity, which summarizes the directional neural…

Methodology · Statistics 2026-04-02 Haiyue Song , Ani Eloyan , Youjin Lee

With distinct advantages in power over behavioral phenotypes, brain imaging traits have become emerging endophenotypes to dissect molecular contributions to behaviors and neuropsychiatric illnesses. Among different imaging features, brain…

Applications · Statistics 2022-12-05 Yize Zhao , Changgee Chang , Jingwen Zhang , Zhengwu Zhang

Machine Learning (ML) is increasingly being used for computer aided diagnosis of brain related disorders based on structural magnetic resonance imaging (MRI) data. Most of such work employs biologically and medically meaningful hand-crafted…

Machine Learning · Computer Science 2018-05-04 Ayush Jaiswal , Dong Guo , Cauligi S. Raghavendra , Paul Thompson

The field of neuroimaging has truly become data rich, and novel analytical methods capable of gleaning meaningful information from large stores of imaging data are in high demand. Those methods that might also be applicable on the level of…

Human cognition is supported by brain structural connectivity wherein weak connectivity with weights several orders of magnitude smaller than those of strong connectivity, has been treated as noise and ignored from analysis over a long…

Neurons and Cognition · Quantitative Biology 2026-03-20 Rong Wang , Zhao Chang , Xuechun Liu , Daniel Kristanto , Étienne Gérard Guy Gartner , Xinyang Liu , Mianxin Liu , Ying Wu , Ming Lui , Changsong Zhou

One of the crucial questions in neuroscience is how a rich functional repertoire of brain states relates to its underlying structural organization. How to study the associations between these structural and functional layers is an open…

Neurons and Cognition · Quantitative Biology 2018-02-22 Enrico Amico , Joaquín Goñi

Over the last years, increasing evidence has fuelled the hypothesis that Autism Spectrum Disorder (ASD) is a condition of altered brain functional connectivity. The great majority of these empirical studies rely on functional magnetic…

Neurons and Cognition · Quantitative Biology 2010-08-02 Pablo Barttfeld , Bruno Wicker , Sebastián Cukier , Silvana Navarta , Sergio Lew , Mariano Sigman

The brain is often studied from a network perspective, where functional activity is assessed using functional Magnetic Resonance Imaging (fMRI) to estimate connectivity between predefined neuronal regions. Functional connectivity can be…

Applications · Statistics 2025-07-22 Olivier Bisson , Yanis Aeschlimann , Samuel Deslauriers-Gauthier , Xavier Pennec

Resting-state functional MRI (rs-fMRI) scans hold the potential to serve as a diagnostic or prognostic tool for a wide variety of conditions, such as autism, Alzheimer's disease, and stroke. While a growing number of studies have…

Computer Vision and Pattern Recognition · Computer Science 2018-06-14 Meenakshi Khosla , Keith Jamison , Amy Kuceyeski , Mert Sabuncu

Knowledge of functional groupings of neurons can shed light on structures of neural circuits and is valuable in many types of neuroimaging studies. However, accurately determining which neurons carry out similar neurological tasks via…

Machine Learning · Statistics 2019-06-03 Tianyi Yao , Genevera I. Allen

Recent advances in neuroimaging along with algorithmic innovations in statistical learning from network data offer a unique pathway to integrate brain structure and function, and thus facilitate revealing some of the brain's organizing…

Signal Processing · Electrical Eng. & Systems 2021-12-21 Yang Li , Gonzalo Mateos , Zhengwu Zhang

In the high-dimensional landscape, addressing the challenges of covariance regression with high-dimensional covariates has posed difficulties for conventional methodologies. This paper addresses these hurdles by presenting a novel approach…

Methodology · Statistics 2024-04-11 Yuheng He , Changliang Zou , Yi Zhao

We present a statistical framework that jointly models brain shape and functional connectivity, which are two complex aspects of the brain that have been classically studied independently. We adopt a Riemannian modeling approach to account…

Methodology · Statistics 2024-04-26 Eardi Lila , John A. D. Aston