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This paper describes a novel system for automatic classification of images obtained from Anti-Nuclear Antibody (ANA) pathology tests on Human Epithelial type 2 (HEp-2) cells using the Indirect Immunofluorescence (IIF) protocol. The IIF…

Cell Behavior · Quantitative Biology 2014-04-15 Arnold Wiliem , Conrad Sanderson , Yongkang Wong , Peter Hobson , Rodney F. Minchin , Brian C. Lovell

Classification of HEp-2 cell patterns plays a significant role in the indirect immunofluorescence test for identifying autoimmune diseases in the human body. Many automatic HEp-2 cell classification methods have been proposed in recent…

Computer Vision and Pattern Recognition · Computer Science 2020-08-07 Saimunur Rahman , Lei Wang , Changming Sun , Luping Zhou

Efficient Human Epithelial-2 (HEp-2) cell image classification can facilitate the diagnosis of many autoimmune diseases. This paper presents an automatic framework for this classification task, by utilizing the deep convolutional neural…

Computer Vision and Pattern Recognition · Computer Science 2015-05-19 Zhimin Gao , Lei Wang , Luping Zhou , Jianjia Zhang

In the diagnosis of autoimmune diseases, an important task is to classify images of slides containing several HEp-2 cells. All cells from one slide share the same label, and by classifying cells from one slide independently, some…

Computer Vision and Pattern Recognition · Computer Science 2014-02-07 David M. J. Tax , Veronika Cheplygina , Marco Loog

The Anti-Nuclear Antibody (ANA) clinical pathology test is commonly used to identify the existence of various diseases. A hallmark method for identifying the presence of ANAs is the Indirect Immunofluorescence method on Human Epithelial…

Cell Behavior · Quantitative Biology 2013-04-05 Arnold Wiliem , Yongkang Wong , Conrad Sanderson , Peter Hobson , Shaokang Chen , Brian C. Lovell

\textit{Indirect Immunofluorescence Imaging of Human Epithelial Type 2} (HEp-2) cells is an effective way to identify the presence of Anti-Nuclear Antibody (ANA). Most existing works on HEp-2 cell classification mainly focus on feature…

Computer Vision and Pattern Recognition · Computer Science 2015-09-09 Xianbiao Qi , Guoying Zhao , Jie Chen , Matti Pietikäinen

Automatic classification of Human Epithelial Type-2 (HEp-2) cells staining patterns is an important and yet a challenging problem. Although both shallow and deep methods have been applied, the study of deep convolutional networks (CNNs) on…

Computer Vision and Pattern Recognition · Computer Science 2018-02-15 Hongwei Li , Wei-Shi Zheng , Jianguo Zhang

Recently, there has been a growing interest in developing Computer Aided Diagnostic (CAD) systems for improving the reliability and consistency of pathology test results. This paper describes a novel CAD system for the Anti-Nuclear Antibody…

Computer Vision and Pattern Recognition · Computer Science 2016-11-15 Arnold Wiliem , Peter Hobson , Brian C. Lovell

The popular use of histopathology images, such as hematoxylin and eosin (H&E), has proven to be useful in detecting tumors. However, moving such cancer cases forward for treatment requires accurate on the amount of the human epidermal…

Computer Vision and Pattern Recognition · Computer Science 2025-12-30 Olaide N. Oyelade , Oliver Hoxey , Yulia Humrye

We present a method for automatic cell classification in tissue samples using an automated training set from multiplexed immunofluorescence images. The method utilizes multiple markers stained in situ on a single tissue section on a robust…

Image and Video Processing · Electrical Eng. & Systems 2020-07-21 Alberto Santamaria-Pang , Anup Sood , Dan Meyer , Aritra Chowdhury , Fiona Ginty

Human epidermal growth factor receptor 2 (HER2) is a critical protein in cancer cell growth that signifies the aggressiveness of breast cancer (BC) and helps predict its prognosis. Accurate assessment of immunohistochemically (IHC) stained…

The antinuclear antibody detection with human epithelial cells is a popular approach for autoimmune diseases diagnosis. The manual evaluation demands time, effort and capital, and automation in screening can greatly aid the physicians in…

Computer Vision and Pattern Recognition · Computer Science 2018-10-31 Vibha Gupta , Arnav Bhavsar

High-quality whole-slide scanning is expensive, complex, and time-consuming, thus limiting the acquisition and utilization of high-resolution histopathology images in daily clinical work. Deep learning-based single-image super-resolution…

Image and Video Processing · Electrical Eng. & Systems 2024-11-08 Minghong Duan , Linhao Qu , Zhiwei Yang , Manning Wang , Chenxi Zhang , Zhijian Song

Immunohistochemistry (IHC) staining plays a significant role in the evaluation of diseases such as breast cancer. The H&E-to-IHC transformation based on generative models provides a simple and cost-effective method for obtaining IHC images.…

Computer Vision and Pattern Recognition · Computer Science 2025-02-28 Yifan Jia , Xingda Yu , Zhengyang Ji , Songning Lai , Yutao Yue

To realize high-accuracy classification of high spatial resolution (HSR) images, this letter proposes a new multi-feature fusion-based scene classification framework (MF2SCF) by fusing local, global, and color features of HSR images.…

Image and Video Processing · Electrical Eng. & Systems 2021-05-25 Zhengrui Huang

We present an image-conditioned point cloud completion approach that treats images as the primary geometric source rather than a secondary guide. To this end, we introduce an Image-to-Point (I2P) module that can reconstruct complete point…

Computer Vision and Pattern Recognition · Computer Science 2026-05-27 Azhar Hussian , Marina Ritthaler , André Kaup , Vasileios Belagiannis

The overexpression of the human epidermal growth factor receptor 2 (HER2) in breast cells is a key driver of HER2-positive breast cancer, a highly aggressive subtype requiring precise diagnosis and targeted therapy. Immunohistochemistry…

Image and Video Processing · Electrical Eng. & Systems 2026-03-10 Sara Rehmat , Hafeez Ur Rehman , Byeong-Gwon Kang , Sarra Ayouni , Yunyoung Nam

Image-to-point-cloud (I2P) registration aims to align 2D images with 3D point clouds by establishing reliable 2D-3D correspondences. The drastic modality gap between images and point clouds makes it challenging to learn features that are…

Computer Vision and Pattern Recognition · Computer Science 2026-03-31 Pei An , Junfeng Ding , Jiaqi Yang , Yulong Wang , Jie Ma , Liangliang Nan

While Electrical Impedance Tomography (EIT) has found many biomedicine applications, a better resolution is needed to provide quantitative analysis for tissue engineering and regenerative medicine. This paper proposes an impedance-optical…

Image and Video Processing · Electrical Eng. & Systems 2021-12-09 Zhe Liu , Pierre Bagnaninchi , Yunjie Yang

Histology imaging is an essential diagnosis method to finalize the grade and stage of cancer of different tissues, especially for breast cancer diagnosis. Specialists often disagree on the final diagnosis on biopsy tissue due to the complex…

Computer Vision and Pattern Recognition · Computer Science 2019-09-17 Yongxiang Huang , Albert Chi-shing Chung
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