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We present a first-principles molecular dynamics (MD) simulation and expound upon a mechanism of oxygen depletion hypothesis to explain the mitigation of normal tissue injury observed in ultra-high-dose-rate (UHDR) FLASH radiotherapy. We…

Medical Physics · Physics 2021-06-09 Ramin Abolfath , David Grosshans , Radhe Mohan

Recent studies suggest a potential link between the physical structure of mitochondria and neurodegenerative diseases. With advances in Electron Microscopy techniques, it has become possible to visualize the boundary and internal membrane…

Computer Vision and Pattern Recognition · Computer Science 2025-02-11 Faris Serdar Taşel , Efe Çiftci

Reconstructing visual stimuli from measured functional magnetic resonance imaging (fMRI) has been a meaningful and challenging task. Previous studies have successfully achieved reconstructions with structures similar to the original images,…

Computer Vision and Pattern Recognition · Computer Science 2023-03-27 Yizhuo Lu , Changde Du , Dianpeng Wang , Huiguang He

Advanced photonic tools may enable researchers and clinicians to visualize, track, control and manipulate biological processes at the single-cell level in space and time. Biological systems are complex and highly organized on both spatial…

Optics · Physics 2021-11-30 Alina Karabchevsky , Tal Elbaz , Aviad Katiyi , Ofer Prager , Alon Friedman

Optogenetics has emerged as an exciting tool for manipulating neural activity, which in turn, can modulate behavior in live organisms. However, detecting the response to the optical stimulation requires electrophysiology with physical…

Optical pump-probe setups are commonly used for excitation and investigation of the spin dynamics in various types of magnetic materials. However, usually the spatially homogeneous excitation is considered. In the present study we describe…

In this paper, we propose an efficient, fast, and versatile distillation method to accelerate the generation of pre-trained diffusion models: Flash Diffusion. The method reaches state-of-the-art performances in terms of FID and CLIP-Score…

Computer Vision and Pattern Recognition · Computer Science 2024-12-19 Clément Chadebec , Onur Tasar , Eyal Benaroche , Benjamin Aubin

The field of biomedical imaging has undergone a rapid growth in recent years, mostly due to the implementation of ad-hoc designed experimental setups, theoretical support methods and numerical reconstructions. Especially for biological…

Biological Physics · Physics 2017-06-30 Daniele Ancora

The photodissociation of the HD+ molecular ion in intense short- pulsed linearly polarized laser fields is studied using a time- dependent wave-packet approach where molecular rotation is fully included. We show that applying a coherent…

chem-ph · Physics 2019-04-04 Eric Charron , Annick Giusti-Suzor , Frederick Mies

FLASH radiation therapy calls for the delivery of fast bursted spills of particles with dose delivery times of the order of milliseconds. The requirements overlap with fundamental physics experimental requests that are being studied at…

Accelerator Physics · Physics 2022-08-31 Pablo A. Arrutia Sota , Philip N. Burrows , Matthew A. Fraser , Francesco M. Velotti

It is critical to characterize the carrier and instantaneous frequency distribution variation in ultrafast processes, all of which are determined by the optical phase. Nevertheless, there is no method that can single-shot record the…

Optics · Physics 2021-06-18 Wenchao Wang , Tianhao Xian , Li Zhan

Multilayer microparticles with a liquid core and a polycomposite light-absorbing shell are important components of modern bio- and medical technologies, in particular, as transport microcontainers in the system of targeted delivery of…

Optics · Physics 2023-04-05 Yury E. Geints , Ekaterina K. Panina

Recent results from animal irradiation studies have rekindled interest in the potential of ultra-high dose rate irradiation (also known as FLASH) for reducing normal tissue toxicity. However, despite mounting evidence of a "FLASH effect", a…

Medical Physics · Physics 2019-08-06 Guillem Pratx , Daniel S Kapp

Fluorescence microscopy is a quintessential tool for observing cells and understanding the underlying mechanisms of life-sustaining processes of all living organisms. The problem of extracting 3D shape of mitochondria from fluorescence…

Image and Video Processing · Electrical Eng. & Systems 2023-03-06 Abhinanda R. Punnakkal , Suyog S Jadhav , Alexander Horsch , Krishna Agarwal , Dilip K. Prasad

Morphology of mitochondria plays critical roles in mediating their physiological functions. Accurate segmentation of mitochondria from 3D electron microscopy (EM) images is essential to quantitative characterization of their morphology at…

Computer Vision and Pattern Recognition · Computer Science 2022-06-16 Yunpeng Xiao , Youpeng Zhao , Ge Yang

We have probed the fragmentation dynamics in a bent triatomic molecule, water, a non-planar molecule, methanol, and a planar ring-structured molecule, benzene, using 100 fs duration pulses of linearly and circularly polarized, infrared,…

Atomic Physics · Physics 2009-11-10 F A Rajgara , M Krishnamurthy , D Mathur

Attosecond laser pulses open the door to resolve microscopic electron dynamics in time. Experiments performed include the decay of a core hole, the time-resolved measurement of photo ionization and electron tunneling. The processes…

Atomic and Molecular Clusters · Physics 2011-11-09 Ionut Georgescu , Ulf Saalmann , Jan M. Rost

Abridged. A large fraction of stars are found in binary systems. It is therefore important for our understanding of the star formation process, to investigate the fragmentation of dense molecular cores. We study the influence of the…

Astrophysics · Physics 2009-11-13 P. Hennebelle , R. Teyssier

Short-wavelength free-electron lasers with their ultrashort pulses at high intensities have originated new approaches for tracking molecular dynamics from the vista of specific sites. X-ray pump X-ray probe schemes even allow to address…

Laser-induced modification of transparent solids by intense femtosecond laser pulses allows fast integration of nanophotonic and nanofluidic devices with controlled optical properties. So far, the local and dynamic nature of the…