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Random Boolean networks (RBNs) are models of genetic regulatory networks. It is useful to describe RBNs as self-organizing systems to study how changes in the nodes and connections affect the global network dynamics. This article reviews…

Adaptation and Self-Organizing Systems · Physics 2010-09-24 Carlos Gershenson

Random Boolean networks (RBNs) have been a popular model of genetic regulatory networks for more than four decades. However, most RBN studies have been made with random topologies, while real regulatory networks have been found to be…

Cellular Automata and Lattice Gases · Physics 2015-03-17 Rodrigo Poblanno-Balp , Carlos Gershenson

Random Boolean networks have been used widely to explore aspects of gene regulatory networks. A modified form of the model through which to systematically explore the effects of increasing the number of gene states has previously been…

Molecular Networks · Quantitative Biology 2023-02-06 Larry Bull

In this work, several random Boolean networks (RBN) are generated and analyzed from two characteristics: their time evolution diagram and their transition diagram. For this purpose, its randomness is estimated using three measures, of which…

Information Theory · Computer Science 2024-09-04 Manuel de J. Luevano , Alejandro Puga

We study information processing in populations of Boolean networks with evolving connectivity and systematically explore the interplay between the learning capability, robustness, the network topology, and the task complexity. We solve a…

Disordered Systems and Neural Networks · Physics 2015-03-19 Alireza Goudarzi , Christof Teuscher , Natali Gulbahce , Thimo Rohlf

We provide the first classification of different types of Random Boolean Networks (RBNs). We study the differences of RBNs depending on the degree of synchronicity and determinism of their updating scheme. For doing so, we first define…

Computational Complexity · Computer Science 2007-05-23 Carlos Gershenson

It has been shown that uniform as well as non-uniform cellular automata (CA) can be evolved to perform certain computational tasks. Random Boolean networks are a generalization of two-state cellular automata, where the interconnection…

Disordered Systems and Neural Networks · Physics 2007-05-23 Bertrand Mesot , Christof Teuscher

Recent progress in experimental techniques has enabled us to quantitatively study stochastic and flexible behavior of biological systems. For example, gene regulatory networks perform stochastic information processing and their…

Statistical Mechanics · Physics 2018-06-21 Shun Otsubo , Takahiro Sagawa

Boolean networks (BNs) are widely used to model the qualitative dynamics of biological systems. Besides the logical rules determining the evolution of each component with respect to the state of its regulators, the scheduling of component…

Logic in Computer Science · Computer Science 2019-06-03 Thomas Chatain , Stefan Haar , Juraj Kolčák , Loïc Paulevé , Aalok Thakkar

The amount of mutual information contained in time series of two elements gives a measure of how well their activities are coordinated. In a large, complex network of interacting elements, such as a genetic regulatory network within a cell,…

Other Quantitative Biology · Quantitative Biology 2009-11-13 Andre S. Ribeiro , Stuart A. Kauffman , Jason Lloyd-Price , Björn Samuelsson , Joshua E. S. Socolar

The study of the response of complex dynamical social, biological, or technological networks to external perturbations has numerous applications. Random Boolean Networks (RBNs) are commonly used a simple generic model for certain dynamics…

Disordered Systems and Neural Networks · Physics 2009-04-29 Qiming Lu , Christof Teuscher

Gene regulatory networks (GRNs) play a central role in cellular decision-making. Understanding their structure and how it impacts their dynamics constitutes thus a fundamental biological question. GRNs are frequently modeled as Boolean…

Molecular Networks · Quantitative Biology 2024-01-19 Claus Kadelka , Taras-Michael Butrie , Evan Hilton , Jack Kinseth , Addison Schmidt , Haris Serdarevic

The goal of this tutorial is to promote interest in the study of random Boolean networks (RBNs). These can be very interesting models, since one does not have to assume any functionality or particular connectivity of the networks to study…

Adaptation and Self-Organizing Systems · Physics 2009-09-29 Carlos Gershenson

Diverse biological networks exhibit universal features distinguished from those of random networks, calling much attention to their origins and implications. Here we propose a minimal evolution model of Boolean regulatory networks, which…

Molecular Networks · Quantitative Biology 2014-11-26 Deok-Sun Lee

Graph Neural Networks (GNN) have emerged as a popular and standard approach for learning from graph-structured data. The literature on GNN highlights the potential of this evolving research area and its widespread adoption in real-life…

Machine Learning · Computer Science 2024-03-25 Sukhdeep Singh , Anuj Sharma , Vinod Kumar Chauhan

Heterogeneous information networks (HINs) can be used to model various real-world systems. As HINs consist of multiple types of nodes, edges, and node features, it is nontrivial to directly apply graph neural network (GNN) techniques in…

Machine Learning · Computer Science 2025-01-15 Zhaoqing Li , Maiqi Jiang , Shengyuan Chen , Bo Li , Guorong Chen , Xiao Huang

Developing interpretable models for neurodevelopmental disorders (NDDs) diagnosis presents significant challenges in effectively encoding, decoding, and integrating multimodal neuroimaging data. While many existing machine learning…

Computer Vision and Pattern Recognition · Computer Science 2026-04-24 Yueyang Li , Lei Chen , Wenhao Dong , Shengyu Gong , Zijian Kang , Boyang Wei , Weiming Zeng , Hongjie Yan , Lingbin Bian , Zhiguo Zhang , Wai Ting Siok , Nizhuan Wang

Random boolean networks are a model of genetic regulatory networks that has proven able to describe experimental data in biology. They not only reproduce important phenomena in cell dynamics, but they are also extremely interesting from a…

Dynamical Systems · Mathematics 2015-02-26 Marco Villani , Davide Campioli , Chiara Damiani , Andrea Roli , Alessandro Filisetti , Roberto Serra

Heterogeneous information network (HIN) embedding aims to embed multiple types of nodes into a low-dimensional space. Although most existing HIN embedding methods consider heterogeneous relations in HINs, they usually employ one single…

Social and Information Networks · Computer Science 2019-05-21 Yuanfu Lu , Chuan Shi , Linmei Hu , Zhiyuan Liu

Boolean networks are a valuable class of discrete dynamical systems models, but they remain fundamentally limited by their inability to capture multi-way interactions in their components. To remedy this limitation, we propose a model of…

Dynamical Systems · Mathematics 2024-09-02 Kevin M. Stoltz , Cliff A. Joslyn
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