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The dynamics of systems biological processes are usually modeled by a system of ordinary differential equations (ODEs) with many unknown parameters that need to be inferred from noisy and sparse measurements. Here, we introduce…

Quantitative Methods · Quantitative Biology 2022-02-04 Mitchell Daneker , Zhen Zhang , George Em Karniadakis , Lu Lu

We consider a problem from biological network analysis of determining regions in a parameter space over which there are multiple steady states for positive real values of variables and parameters. We describe multiple approaches to address…

Symbolic Computation · Computer Science 2019-11-25 R. Bradford , J. H. Davenport , M. England , H. Errami , V. Gerdt , D. Grigoriev , C. Hoyt , M. Kosta , O. Radulescu , T. Sturm , A. Weber

Given a graph E we define E-algebraic branching systems, show their existence and how they induce representations of the associated Leavitt path algebra. We also give sufficient conditions to guarantee faithfulness of the representations…

Rings and Algebras · Mathematics 2013-10-09 D. Gonçalves , D. Royer

Symbolic Computation algorithms and their implementation in computer algebra systems often contain choices which do not affect the correctness of the output but can significantly impact the resources required: such choices can benefit from…

Symbolic Computation · Computer Science 2024-09-12 Tereso del Río , Matthew England

In this paper we study the differential systems on Leibniz algebroids. We introduce a class of almost metriplectic manifolds as a special case of Leibniz manifolds. Also, the notion of almost metriplectic algebroid is introduced. These…

Differential Geometry · Mathematics 2007-05-23 G. Ivan , D. Opris

Recurrence is a fundamental characteristic of dynamical systems with complicated behavior. Understanding the inner structure of recurrence is challenging, especially if the system has many degrees of freedom and is subject to noise. We…

Dynamical Systems · Mathematics 2024-12-16 Ulrich Bauer , David Hien , Oliver Junge , Konstantin Mischaikow

In this paper we describe a combined combinatorial/numerical approach to studying equilibria and bifurcations in network models arising in Systems Biology. ODE models of the dynamics suffer from high dimensional parameters which presents a…

Dynamical Systems · Mathematics 2024-11-28 Shane Kepley , Konstantin Mischaikow , Elena Queirolo

Computational modeling of Wnt signaling pathway has gained prominence for its use as computer aided diagnostic tool to develop therapeutic cancer target drugs and predict of test samples as cancerous and non cancerous. This manuscript…

Molecular Networks · Quantitative Biology 2024-11-26 Shriprakash Sinha , Marcel J. T. Reinders , Wim Verhaegh

In this study, we propose a method for extracting the hidden algebraic structures of model parameters that are uniquely determined by observed time-series data and unidentifiable state-space models, explicitly and exhaustively. State-space…

Systems and Control · Electrical Eng. & Systems 2020-12-23 Mizuka Komatsu , Takaharu Yaguchi

In this review, we present some advanced algorithms and programs used in our scientific school with short description of types of astrophysical systems, which we study. However, we discuss mainly mathematical methods, which may be applied…

Instrumentation and Methods for Astrophysics · Physics 2020-11-11 Ivan L. Andronov , Vitalii V. Breus , Larysa S. Kudashkina

Accurately determining and classifying the structure of complex networks is the focus of much current research. One class of network of particular interest are metabolic pathways, which have previously been studied from a graph theoretical…

Mathematical Physics · Physics 2012-10-10 Henry Dorrian , Kieran Smallbone , Jon borresen

A novel algebraic method for finding invariant algebraic curves for a polynomial vector field in $\mathbb{C}^2$ is introduced. The structure of irreducible invariant algebraic curves for Li\'{e}nard dynamical systems $x_t=y$,…

Exactly Solvable and Integrable Systems · Physics 2018-10-03 Maria Demina

To study any dynamical system it is useful to find a partition that allows essentially faithful encoding (injective, up to a small exceptional set) into a subshift. Most topological and measure-theoretic systems can be represented by…

Dynamical Systems · Mathematics 2024-09-04 Sarah Frick , Karl Petersen , Sandi Shields

Population dynamics in systems composed of cyclically competing species has been of increasing interest recently. Here, we investigate a system with four or more species. Using mean field theory, we study in detail the trajectories in…

Populations and Evolution · Quantitative Biology 2015-05-27 C. H. Durney , S. O. Case , M. Pleimling , R. K. P. Zia

Many open problems in biology, as in the physical sciences, display nonlinear and 'chaotic' dynamics, which, to the extent possible, cannot be reasonably understood. Moreover, mathematical models which aim to predict/estimate unknown…

Subcellular Processes · Quantitative Biology 2012-06-26 Sepehr Ehsani

Linear systems under the influence of nonlinear and random linear perturbations, and with random initial and boundary conditions, are discussed. The notion of states of a system is substituted by the notion of the generating vectors for…

General Physics · Physics 2013-10-30 Jerzy Hanckowiak

In a cell or microorganism the processes that generate mass, energy, information transfer, and cell fate specification are seamlessly integrated through a complex network of various cellular constituents and reactions. However, despite the…

Statistical Mechanics · Physics 2009-10-31 H. Jeong , B. Tombor , R. Albert , Z. N. Oltvai , A. -L. Barabasi

We present in this article an algebraic approach to model and simulate road traffic networks. By defining a set of road traffic systems and adequate concatenating operators in that set, we show that large regular road networks can be easily…

Optimization and Control · Mathematics 2014-06-27 Nadir Farhi , Habib Haj-Salem , Jean-Patrick Lebacque

A phylogenetic variety is an algebraic variety parameterized by a statistical model of the evolution of biological sequences along a tree. Understanding this variety is an important problem in the area of algebraic statistics with…

Populations and Evolution · Quantitative Biology 2024-05-22 Luis David Garcia Puente , Marina Garrote-López , Elima Shehu

An external description for nonperiodically sampled multivariable linear systems has been developed. Emphasis is on the sampling period sequence, included among the variables to be handled. The computational procedure is simple and no use…

Dynamical Systems · Mathematics 2010-06-08 Amparo Fúster-Sabater