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In the SysLab project we develop a software engineering method based on a mathematical foundation. The SysLab system model serves as an abstract mathematical model for information systems and their components. It is used to formalize the…

Software Engineering · Computer Science 2014-09-26 Cornel Klein , Bernhard Rumpe , Manfred Broy

Cancer Biotherapy (CB), as opposed to cancer chemotherapy, is the use of macromolecular, biological agents instead of organic chemicals or drugs to treat cancer. Biological agents usually have higher selectivity and have less toxic side…

Biomolecules · Quantitative Biology 2016-02-29 Preety Priya , Vicente M. Reyes

While many good textbooks are available on Protein Structure, Molecular Simulations, Thermodynamics and Bioinformatics methods in general, there is no good introductory level book for the field of Structural Bioinformatics. This book aims…

Biomolecules · Quantitative Biology 2023-07-10 Jose Gavaldá-Garciá , Bas Stringer , Olga Ivanova , Sanne Abeln , K. Anton Feenstra , Halima Mouhib

We describe a binding schema markup language (BSML) for describing data interchange between scientific codes. Such a facility is an important constituent of scientific problem solving environments (PSEs). BSML is designed to integrate with…

Computational Engineering, Finance, and Science · Computer Science 2007-05-23 Alex Verstak , Naren Ramakrishnan , Layne T. Watson , Jian He , Clifford A. Shaffer , Kyung Kyoon Bae , Jing Jiang , William H. Tranter , Theodore S. Rappaport

While data sharing is crucial for knowledge development, privacy concerns and strict regulation (e.g., European General Data Protection Regulation (GDPR)) unfortunately limit its full effectiveness. Synthetic tabular data emerges as an…

Machine Learning · Computer Science 2021-06-02 Zilong Zhao , Aditya Kunar , Hiek Van der Scheer , Robert Birke , Lydia Y. Chen

Nowadays, information management systems deal with data originating from different sources including relational databases, NoSQL data stores, and Web data formats, varying not only in terms of data formats, but also in the underlying data…

Databases · Computer Science 2012-11-08 Michael Hausenblas , Boris Villazon-Terrazas , Richard Cyganiak

Refactoring is a change made to the internal structure of software to make it easier to understand and cheaper to modify without changing its observable behaviour. A database refactoring is a small change to the database schema which…

Software Engineering · Computer Science 2010-09-09 Patrick O'Beirne

Bioinformatics research is characterized by voluminous and incremental datasets and complex data analytics methods. The machine learning methods used in bioinformatics are iterative and parallel. These methods can be scaled to handle big…

Computational Engineering, Finance, and Science · Computer Science 2015-06-17 Hirak Kashyap , Hasin Afzal Ahmed , Nazrul Hoque , Swarup Roy , Dhruba Kumar Bhattacharyya

This is a thought piece on data-intensive science requirements for databases and science centers. It argues that peta-scale datasets will be housed by science centers that provide substantial storage and processing for scientists who access…

Databases · Computer Science 2007-05-23 Jim Gray , David T. Liu , Maria Nieto-Santisteban , Alexander S. Szalay , David DeWitt , Gerd Heber

Synthetic data generation using large language models (LLMs) demonstrates substantial promise in addressing biomedical data challenges and shows increasing adoption in biomedical research. This study systematically reviews recent advances…

Computation and Language · Computer Science 2026-02-18 Hanshu Rao , Weisi Liu , Haohan Wang , I-Chan Huang , Zhe He , Xiaolei Huang

Design patterns are generalized solutions to frequently recurring problems. They were initially developed by architects and computer scientists to create a higher level of abstraction for their designs. Here, we extend these concepts to…

Molecular Networks · Quantitative Biology 2023-10-13 Steven S. Andrews , H. Steven Wiley , Herbert M. Sauro

Tabular data is difficult to analyze and to search through, yielding for new tools and interfaces that would allow even non tech-savvy users to gain insights from open datasets without resorting to specialized data analysis tools or even…

Information Retrieval · Computer Science 2017-08-31 Svitlana Vakulenko , Vadim Savenkov

SynDiffix is a new open-source tool for structured data synthesis. It has anonymization features that allow it to generate multiple synthetic tables while maintaining strong anonymity. Compared to the more common single-table approach,…

Cryptography and Security · Computer Science 2024-03-14 Paul Francis

The explosion of scientific literature has made the efficient and accurate extraction of structured data a critical component for advancing scientific knowledge and supporting evidence-based decision-making. However, existing tools often…

Human-Computer Interaction · Computer Science 2025-11-06 Xingbo Wang , Samantha L. Huey , Rui Sheng , Saurabh Mehta , Fei Wang

Structured Query Language (SQL) has remained the standard query language for databases. SQL is highly optimized for processing structured data laid out in relations. Meanwhile, in the present application development landscape, it is highly…

Databases · Computer Science 2026-04-24 Udesh Kumarasinghe , Tyler Liu , Ahmed R. Mahmood , Chunwei Liu , Walid G. Aref

Table extraction from PDF and image documents is a ubiquitous task in the real-world. Perfect extraction quality is difficult to achieve with one single out-of-box model due to (1) the wide variety of table styles, (2) the lack of training…

Human-Computer Interaction · Computer Science 2021-02-18 Nancy Xin Ru Wang , Douglas Burdick , Yunyao Li

The information in tables can be an important complement to text, making table-based question answering (QA) systems of great value. The intrinsic complexity of handling tables often adds an extra burden to both model design and data…

Computation and Language · Computer Science 2022-07-11 Zhengbao Jiang , Yi Mao , Pengcheng He , Graham Neubig , Weizhu Chen

In this paper, we define a category DB, called the category of simplicial databases, whose objects are databases and whose morphisms are data-preserving maps. Along the way we give a precise formulation of the category of relational…

Databases · Computer Science 2009-04-15 David I. Spivak

Spreadsheets are the go-to tool for computerized calculation and modelling, but are hard to comprehend and adapt after reaching a certain complexity. In general, cognition of complex systems is facilitated by having a higher order mental…

Software Engineering · Computer Science 2018-09-11 Patrick Koch
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