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Early stage drug discovery and molecular design projects often follow iterative design-make-test cycles. The selection of which compounds to synthesize from all possible candidate compounds is a complex decision inherent to these design…

Quantitative Methods · Quantitative Biology 2025-03-19 Jenna C. Fromer , Alexandra D. Volkova , Connor W. Coley

We propose the algorithm that solves the symmetric cone programs (SCPs) by iteratively calling the projection and rescaling methods the algorithms for solving exceptional cases of SCP. Although our algorithm can solve SCPs by itself, we…

Optimization and Control · Mathematics 2024-01-22 Shin-ichi Kanoh , Akiko Yoshise

We introduce a new generic Archetype technique for source classification and identification, based on the NP-complete set cover problem (SCP) in computer science and operations research (OR). We have developed a new heuristic SCP solver, by…

Instrumentation and Methods for Astrophysics · Physics 2016-06-24 Guangtun Zhu

This paper presents the design and analysis of a Hybrid High-Order (HHO) approximation for a distributed optimal control problem governed by the Poisson equation. We propose three distinct schemes to address unconstrained control problems…

Numerical Analysis · Mathematics 2025-01-14 Gouranga Mallik , Ramesh Chandra Sau

We focus on a simulation-based optimization problem of choosing the best design from the feasible space. Although the simulation model can be queried with finite samples, its internal processing rule cannot be utilized in the optimization…

Machine Learning · Computer Science 2021-11-02 Kuo Li , Qing-Shan Jia , Jiaqi Yan

Several constrained optimization problems have been adequately solved over the years thanks to advances in the metaheuristics area. In this paper, we evaluate a novel self-adaptive and auto-constructive metaheuristic called Drone Squadron…

Neural and Evolutionary Computing · Computer Science 2017-08-07 Vinícius Veloso de Melo

In this paper, we present approximation algorithms for combinatorial optimization problems under probabilistic constraints. Specifically, we focus on stochastic variants of two important combinatorial optimization problems: the k-center…

Data Structures and Algorithms · Computer Science 2008-09-03 Shipra Agrawal , Amin Saberi , Yinyu Ye

This paper proposes distributed algorithms to solve robust convex optimization (RCO) when the constraints are affected by nonlinear uncertainty. We adopt a scenario approach by randomly sampling the uncertainty set. To facilitate the…

Distributed, Parallel, and Cluster Computing · Computer Science 2018-01-16 Keyou You , Roberto Tempo , Pei Xie

In this work we focus on efficient heuristics for solving a class of stochastic planning problems that arise in a variety of business, investment, and industrial applications. The problem is best described in terms of future buy and sell…

Artificial Intelligence · Computer Science 2013-01-14 Milos Hauskrecht , Eli Upfal

This paper proposes a problem-independent GRASP metaheuristic using the random-key optimizer (RKO) paradigm. GRASP (greedy randomized adaptive search procedure) is a metaheuristic for combinatorial optimization that repeatedly applies a…

Neural and Evolutionary Computing · Computer Science 2024-11-08 Antonio A. Chaves , Mauricio G. C. Resende , Ricardo M. A. Silva

We introduce and study a novel generalization of the classical Knapsack Problem (KP), called the Colored Knapsack Problem (CKP). In this problem, the items are partitioned into classes of colors and the packed items need to be ordered such…

Optimization and Control · Mathematics 2026-02-13 Fabio Ciccarelli , Alexander Helber , Erik Mühmer

In this paper, we present a novel approach for conformal prediction (CP), in which we aim to identify a set of promising prediction candidates -- in place of a single prediction. This set is guaranteed to contain a correct answer with high…

Machine Learning · Computer Science 2021-02-03 Adam Fisch , Tal Schuster , Tommi Jaakkola , Regina Barzilay

Astrochemical simulations are a powerful tool for revealing chemical evolution in the interstellar medium. Astrochemical calculations require efficient processing of large matrices for the chemical networks. The large chemical reaction…

Instrumentation and Methods for Astrophysics · Physics 2023-12-11 Kazutaka Motoyama , Ruben Krasnopolsky , Hsien Shang , Kento Aida , Eisaku Sakane

This paper presents the Firefighter Optimization (FFO) algorithm as a new hybrid metaheuristic for optimization problems. This algorithm stems inspiration from the collaborative strategies often deployed by firefighters in firefighting…

Neural and Evolutionary Computing · Computer Science 2024-06-04 M. Z. Naser , A. Z. Naser

In model predictive control (MPC) an optimization problem has to be solved at each time step, which in real-time applications makes it important to solve these optimization problems efficiently and to have good upper bounds on worst-case…

Optimization and Control · Mathematics 2020-04-13 Daniel Arnström , Daniel Axehill

The probability distribution describing the state of a Stochastic Reaction Network evolves according to the Chemical Master Equation (CME). It is common to estimated its solution using Monte Carlo methods such as the Stochastic Simulation…

Quantitative Methods · Quantitative Biology 2015-06-18 Benjamin Hepp , Ankit Gupta , Mustafa Khammash

Chemical reaction networks (CRNs) are fundamental computational models used to study the behavior of chemical reactions in well-mixed solutions. They have been used extensively to model a broad range of biological systems, and are primarily…

Molecular Networks · Quantitative Biology 2021-05-13 J. N. Mueller , J. N. Corcoran

With huge design spaces for unique chemical and mechanical properties, we remove a roadblock to computational design of {high-entropy alloys} using a metaheuristic hybrid Cuckoo Search (CS) for "on-the-fly" construction of Super-Cell Random…

Materials Science · Physics 2021-01-19 Rahul Singh , Aayush Sharma , Prashant Singh , Ganesh Balasubramanian , Duane D. Johnson

The surge of explainable artificial intelligence methods seeks to enhance transparency and explainability in machine learning models. At the same time, there is a growing demand for explaining decisions taken through complex algorithms used…

Optimization and Control · Mathematics 2025-06-19 Daan Otto , Jannis Kurtz , S. Ilker Birbil

In the dynamic set cover (SC) problem, the input is a dynamic universe of at most $n$ elements and a fixed collection of $m$ sets, where each element belongs to at most $f$ sets and each set has cost in $[1/C, 1]$. The objective is to…

Data Structures and Algorithms · Computer Science 2025-11-11 Shay Solomon , Amitai Uzrad
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