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Magnetic Resonance Imaging (MRI) provides detailed structural information, while functional MRI (fMRI) captures temporal brain activity. In this work, we present a multimodal deep learning framework that integrates MRI and fMRI for…

Computer Vision and Pattern Recognition · Computer Science 2026-03-17 Anima Kujur , Zahra Monfared

The field of lung nodule detection and cancer prediction has been rapidly developing with the support of large public data archives. Previous studies have largely focused on cross-sectional (single) CT data. Herein, we consider longitudinal…

Ordinal data are quite common in applied statistics. Although some model selection and regularization techniques for categorical predictors and ordinal response models have been developed over the past few years, less work has been done…

Methodology · Statistics 2024-07-26 Aisouda Hoshiyar , Laura H. Gertheiss , Jan Gertheiss

In neuroscience, researchers seek to uncover the connectivity of neurons from large-scale neural recordings or imaging; often people employ graphical model selection and estimation techniques for this purpose. But, existing technologies can…

Machine Learning · Statistics 2021-04-14 Minjie Wang , Genevera I. Allen

Estimation and inference with modern longitudinal data from wearable devices, which consist of biological signals at high-frequency time points, is burdened by massive computational costs. We propose a distributed estimation and inference…

Methodology · Statistics 2023-09-13 Cole Manschot , Emily C. Hector

In this review paper, some applications of the mixed effect modeling in medial image processing and longitudinal analysis is studied. For this purpose, a general structure is extracted from some of the researches in the literature. This…

Medical Physics · Physics 2018-03-13 Fatemeh Nasiri , Oscar Acosta-Tamayo

We consider ``one-at-a-time'' coordinate-wise descent algorithms for a class of convex optimization problems. An algorithm of this kind has been proposed for the $L_1$-penalized regression (lasso) in the literature, but it seems to have…

Computation · Statistics 2007-12-18 Jerome Friedman , Trevor Hastie , Holger Höfling , Robert Tibshirani

Among the most popular variable selection procedures in high-dimensional regression, Lasso provides a solution path to rank the variables and determines a cut-off position on the path to select variables and estimate coefficients. In this…

Methodology · Statistics 2018-06-19 X. Jessie Jeng , Huimin Peng , Wenbin Lu

In this paper, we propose a robust estimator for the location function from multi-dimensional functional data. The proposed estimators are based on the deep neural networks with ReLU activation function. At the meanwhile, the estimators are…

Methodology · Statistics 2022-05-20 Shuoyang Wang , Guanqun Cao

We develop fixed-point algorithms for the approximation of structured matrices with rank penalties. In particular we use these fixed-point algorithms for making approximations by sums of exponentials, or frequency estimation. For the basic…

Numerical Analysis · Mathematics 2016-01-07 Fredrik Andersson , Marcus Carlsson

We propose a shrinkage procedure for simultaneous variable selection and estimation in generalized linear models (GLMs) with an explicit predictive motivation. The procedure estimates the coefficients by minimizing the Kullback-Leibler…

Methodology · Statistics 2010-09-14 Minh-Ngoc Tran , David Nott , Chenlei Leng

In this work, we consider to improve the model estimation efficiency by aggregating the neighbors' information as well as identify the subgroup membership for each node in the network. A tree-based $l_1$ penalty is proposed to save the…

Machine Learning · Statistics 2019-05-29 Xin Zhang , Jia Liu , Zhengyuan Zhu

The Lasso is a very well known penalized regression model, which adds an $L_{1}$ penalty with parameter $\lambda_{1}$ on the coefficients to the squared error loss function. The Fused Lasso extends this model by also putting an $L_{1}$…

Computation · Statistics 2009-10-06 Holger Hoefling

Interpretability is a key issue when applying deep learning models to longitudinal brain MRIs. One way to address this issue is by visualizing the high-dimensional latent spaces generated by deep learning via self-organizing maps (SOM). SOM…

Computer Vision and Pattern Recognition · Computer Science 2023-10-03 Jiahong Ouyang , Qingyu Zhao , Ehsan Adeli , Wei Peng , Greg Zaharchuk , Kilian M. Pohl

We show that the two-stage adaptive Lasso procedure (Zou, 2006) is consistent for high-dimensional model selection in linear and Gaussian graphical models. Our conditions for consistency cover more general situations than those accomplished…

Statistics Theory · Mathematics 2009-03-17 Shuheng Zhou , Sara van de Geer , Peter Bühlmann

Alzheimer's disease (AD) is a progressive and irreversible brain disorder that unfolds over the course of 30 years. Therefore, it is critical to capture the disease progression in an early stage such that intervention can be applied before…

Machine Learning · Computer Science 2024-09-02 Yipei Wang , Bing He , Shannon Risacher , Andrew Saykin , Jingwen Yan , Xiaoqian Wang

High-dimensional multivariate longitudinal data, which arise when many outcome variables are measured repeatedly over time, are becoming increasingly common in social, behavioral and health sciences. We propose a latent variable model for…

Methodology · Statistics 2025-12-09 Sze Ming Lee , Yunxiao Chen , Tony Sit

The estimation of high dimensional precision matrices has been a central topic in statistical learning. However, as the number of parameters scales quadratically with the dimension $p$, many state-of-the-art methods do not scale well to…

Computation · Statistics 2019-07-10 Cheng Wang , Binyan Jiang

Precision medicine provides customized treatments to patients based on their characteristics and is a promising approach to improving treatment efficiency. Large scale omics data are useful for patient characterization, but often their…

Machine Learning · Statistics 2023-01-24 Jianchang Hu , Silke Szymczak

In this work, we propose a high-order multiscale method for an elliptic model problem with rough and possibly highly oscillatory coefficients. Convergence rates of higher order are obtained using the regularity of the right-hand side only.…

Numerical Analysis · Mathematics 2023-04-18 Zhaonan Dong , Moritz Hauck , Roland Maier