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This paper is concerned with a phase field system of Cahn-Hilliard type that is related to a tumor growth model and consists of three equations in terms of the variables order parameter, chemical potential and nutrient concentration. This…

Analysis of PDEs · Mathematics 2015-03-04 Pierluigi Colli , Gianni Gilardi , Elisabetta Rocca , Jürgen Sprekels

The paper deals with a phase field system of Cahn-Hilliard type. For positive viscosity coefficients, the authors prove an existence and uniqueness result and study the long time behavior of the solution by assuming the nonlinearities to be…

Analysis of PDEs · Mathematics 2014-03-24 Pierluigi Colli , Gianni Gilardi , Danielle Hilhorst

A distributed optimal control problem for a phase field system which physical context is that of tumor growth is discussed. The system we are going to take into account consists of a Cahn-Hilliard equation for the phase variable (relative…

Analysis of PDEs · Mathematics 2021-01-20 Andrea Signori

We consider a particular phase field system which physical context is that of tumor growth dynamics. The model we deal with consists of a Cahn-Hilliard type equation governing the evolution of the phase variable which takes into account the…

Analysis of PDEs · Mathematics 2019-08-30 Andrea Signori

We introduce a new diffuse interface model for tumour growth in the presence of a nutrient, in which we take into account mechanical effects and reversible tissue damage. The highly nonlinear PDEs system mainly consists of a Cahn-Hilliard…

Analysis of PDEs · Mathematics 2025-10-09 Giulia Cavalleri

In this paper, we study a phase field model for a tumor growth model of Cahn--Hilliard type in which the often assumed parabolic relaxation of the chemical potential is replaced by a hyperbolic one. We show that the resulting…

Analysis of PDEs · Mathematics 2026-02-16 Pierluigi Colli , Elisabetta Rocca , Jürgen Sprekels

This article considers a limit system by passing to the limit in the following Cahn--Hilliard type phase field system related to tumor growth as $\beta\searrow0$: \begin{equation*} \begin{cases} \alpha\partial_{t} \mu_{\beta} + \partial_{t}…

Analysis of PDEs · Mathematics 2019-05-01 Shunsuke Kurima

This paper is concerned with a diffusion model of phase-field type, consisting of a parabolic system of two partial differential equations, interpreted as balances of microforces and microenergy, for two unknowns: the problem's order…

Analysis of PDEs · Mathematics 2011-09-16 Pierluigi Colli , Gianni Gilardi , Paolo Podio-Guidugli , Jürgen Sprekels

In this paper, we study a system of three evolutionary operator equations involving fractional powers of selfadjoint, monotone, unbounded, linear operators having compact resolvents. This system constitutes a generalized and relaxed version…

Analysis of PDEs · Mathematics 2019-08-29 Pierluigi Colli , Gianni Gilardi , Jürgen Sprekels

We analyze a phase field model for tumor growth consisting of a Cahn-Hilliard-Brinkman system, ruling the evolution of the tumor mass, coupled with an advection-reaction-diffusion equation for a chemical species acting as a nutrient. The…

Analysis of PDEs · Mathematics 2023-07-26 Pierluigi Colli , Gianni Gilardi , Andrea Signori , Jürgen Sprekels

Mechanical effects have mostly been neglected so far in phase field tumour models that are based on a Cahn-Hilliard approach. In this paper we study a macroscopic mechanical model for tumour growth in which cell-cell adhesion effects are…

Analysis of PDEs · Mathematics 2021-01-20 Harald Garcke , Kei Fong Lam , Andrea Signori

In this work, we study a model consisting of a Cahn-Hilliard-type equation for the concentration of tumour cells coupled to a reaction-diffusion type equation for the nutrient density and a Brinkman-type equation for the velocity. We equip…

Analysis of PDEs · Mathematics 2018-11-19 Matthias Ebenbeck , Harald Garcke

In this paper we study nonlocal-to-local asymptotics for a tumor-growth model coupling a viscous Cahn-Hilliard equation describing the tumor proportion with a reaction-diffusion equation for the nutrient phase parameter. First, we prove…

Analysis of PDEs · Mathematics 2023-11-20 Elisa Davoli , Elisabetta Rocca , Luca Scarpa , Lara Trussardi

We consider an evolutionary PDE system coupling the Cahn-Hilliard equation with singular potential, mass source and transport effects, to a Brinkman-type relation for the macroscopic velocity field and to a further equation describing the…

Analysis of PDEs · Mathematics 2024-11-20 Giulio Schimperna

We introduce a new phase field model for tumour growth where viscoelastic effects are taken into account. The model is derived from basic thermodynamical principles and consists of a convected Cahn--Hilliard equation with source terms for…

Numerical Analysis · Mathematics 2024-06-21 Harald Garcke , Balázs Kovács , Dennis Trautwein

We introduce the problem of parameter identification for a coupled nonlocal Cahn-Hilliard-reaction-diffusion PDE system stemming from a recently introduced tumor growth model. The inverse problem of identifying relevant parameters is…

Analysis of PDEs · Mathematics 2020-09-24 Elisabetta Rocca , Luca Scarpa , Andrea Signori

We are concerned with a nonstandard phase field model of Cahn-Hilliard type. The model, which was introduced by Podio-Guidugli (Ric. Mat. 2006), describes two-species phase segregation and consists of a system of two highly nonlinearly…

Analysis of PDEs · Mathematics 2012-12-18 Pierluigi Colli , Gianni Gilardi , Pavel Krejčí , Jürgen Sprekels

We investigate the dynamics of a nonlinear system modeling tumor growth with drug application. The tumor is viewed as a mixture consisting of proliferating, quiescent and dead cells as well as a nutrient in the presence of a drug. The…

Analysis of PDEs · Mathematics 2017-05-23 Donatella Donatelli , Konstantina Trivisa

A phase field model for tumour growth is introduced that is based on a Brinkman law for convective velocity fields. The model couples a convective Cahn-Hilliard equation for the evolution of the tumour to a reaction-diffusion-advection…

Analysis of PDEs · Mathematics 2021-09-07 Matthias Ebenbeck , Harald Garcke , Robert Nürnberg

We investigate a multiphase Cahn-Hilliard model for tumor growth with general source terms. The multiphase approach allows us to consider multiple cell types and multiple chemical species (oxygen and/or nutrients) that are consumed by the…

Analysis of PDEs · Mathematics 2022-06-22 Patrik Knopf , Andrea Signori
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