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Unsupervised learning aims at the discovery of hidden structure that drives the observations in the real world. It is essential for success in modern machine learning. Latent variable models are versatile in unsupervised learning and have…

Machine Learning · Computer Science 2016-06-13 Furong Huang

Diffusion kurtosis imaging is an extension of diffusion tensor imaging that provides scientifically and clinically valuable information about brain tissue microstructure but suffers from poor robustness to noise, especially in voxels…

Accurate spatial correspondence between medical images is essential for longitudinal analysis, lesion tracking, and image-guided interventions. Medical image registration methods rely on local intensity-based similarity measures, which fail…

Computer Vision and Pattern Recognition · Computer Science 2026-02-24 Xingyu Zhang , Anna Reithmeir , Fryderyk Kögl , Rickmer Braren , Julia A. Schnabel , Daniel M. Lang

Variable selection for high-dimensional, highly correlated data has long been a challenging problem, often yielding unstable and unreliable models. We propose a resample-aggregate framework that exploits diffusion models' ability to…

Methodology · Statistics 2025-08-20 Minjie Wang , Xiaotong Shen , Wei Pan

Tractography from high-dimensional diffusion magnetic resonance imaging (dMRI) data allows brain's structural connectivity analysis. Recent dMRI studies aim to compare connectivity patterns across subject groups and disease populations to…

We propose a multimodal latent diffusion model that jointly synthesizes volumetric magnetic resonance imaging (MRI) and tabular clinical data within a shared latent space via cross-attention. This approach enables coherent joint…

Image and Video Processing · Electrical Eng. & Systems 2026-05-11 Daniel Mensing , Jan Kapar , Jochen G. Hirsch , Matthias Günther , Horst Hahn , Marvin N. Wright

Diffusion weighted MRI (dMRI) provides a non invasive virtual reconstruction of the brain's white matter structures through tractography. Analyzing dMRI measures along the trajectory of white matter bundles can provide a more specific…

Quantitative Methods · Quantitative Biology 2019-06-21 Samuel St-Jean , Maxime Chamberland , Max A. Viergever , Alexander Leemans

Panel data allows for the modeling of unobserved heterogeneity, significantly raising the number of nuisance parameters and making high dimensionality a practical issue. Meanwhile, temporal and cross-sectional dependence in panel data…

Econometrics · Economics 2025-12-23 Kaicheng Chen

In multiple sclerosis, lesions interfere with automated magnetic resonance imaging analyses such as brain parcellation and deformable registration, while lesion segmentation models are hindered by the limited availability of annotated…

In many modern applications, a dependent functional response is observed for each subject over repeated time, leading to longitudinal functional data. In this paper, we propose a novel statistical procedure to test whether the mean function…

Methodology · Statistics 2024-01-17 Salil Koner , So Young Park , Ana-Maria Staicu

A lateral shear interferometer based digital holographic microscopy has been realized to study the morphology dynamics of Human red blood cells quantitatively. Here, a lateral shear interferometer is embedded with a conventional microscope…

Image and Video Processing · Electrical Eng. & Systems 2019-09-10 Shital Devinder , Ashish Lal , Tathagato Rai Dastidar , Satish Kumar Dubey

Diffusion MRI (dMRI) provides the ability to reconstruct neuronal fibers in the brain, $\textit{in vivo}$, by measuring water diffusion along angular gradient directions in q-space. High angular resolution diffusion imaging (HARDI) can…

Machine Learning · Statistics 2018-05-30 Evan Schwab , René Vidal , Nicolas Charon

Accurate longitudinal analysis of brain MRI is often hindered by evolving lesions, which bias automated neuroimaging pipelines. While deep generative models have shown promise in inpainting these lesions, most existing methods operate…

Image and Video Processing · Electrical Eng. & Systems 2026-03-09 Zahra Karimaghaloo , Dumitru Fetco , Haz-Edine Assemlal , Hassan Rivaz , Douglas L. Arnold

Perfusion-weighted magnetic resonance imaging (MRI) is an imaging technique that allows one to measure tissue perfusion in an organ of interest through the injection of an intravascular paramagnetic contrast agent (CA). Due to a preference…

Computer Vision and Pattern Recognition · Computer Science 2017-08-28 Cagdas Ulas , Christine Preibisch , Jonathan Sperl , Thomas Pyka , Jayashree Kalpathy-Cramer , Bjoern Menze

Understanding the complex myocardial architecture is critical for diagnosing and treating heart disease. However, existing methods often struggle to accurately capture this intricate structure from Diffusion Tensor Imaging (DTI) data,…

Image and Video Processing · Electrical Eng. & Systems 2025-05-14 Mohini Anand , Xavier Tricoche

Single-source domain generalization (SDG) aims to learn a model from a single source domain that can generalize well on unseen target domains. This is an important task in computer vision, particularly relevant to medical imaging where…

Computer Vision and Pattern Recognition · Computer Science 2024-11-11 Boqi Chen , Yuanzhi Zhu , Yunke Ao , Sebastiano Caprara , Reto Sutter , Gunnar Rätsch , Ender Konukoglu , Anna Susmelj

Due to the confined focal length of optical sensors, focusing all objects in a scene with a single sensor is a difficult task. To handle such a situation, image fusion methods are used in multi-focus environment. Discrete Cosine Transform…

Computer Vision and Pattern Recognition · Computer Science 2016-02-25 Ashutosh Mishra , Sudipta Mahapatra , Swapna Banerjee

In the realm of high-resolution (HR), fine-grained image segmentation, the primary challenge is balancing broad contextual awareness with the precision required for detailed object delineation, capturing intricate details and the finest…

Computer Vision and Pattern Recognition · Computer Science 2025-07-01 Qian Yu , Peng-Tao Jiang , Hao Zhang , Jinwei Chen , Bo Li , Lihe Zhang , Huchuan Lu

Recently, segmentation methods based on Convolutional Neural Networks (CNNs) showed promising performance in automatic Multiple Sclerosis (MS) lesions segmentation. These techniques have even outperformed human experts in controlled…

Image and Video Processing · Electrical Eng. & Systems 2021-07-26 Reda Abdellah Kamraoui , Vinh-Thong Ta , Thomas Tourdias , Boris Mansencal , José V Manjon , Pierrick Coupé