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Early diagnosis of Alzheimer's disease and its prodromal stage, also known as mild cognitive impairment (MCI), is critical since some patients with progressive MCI will develop the disease. We propose a multi-stream deep convolutional…

Image and Video Processing · Electrical Eng. & Systems 2023-08-01 Mona Ashtari-Majlan , Abbas Seifi , Mohammad Mahdi Dehshibi

Inferring the functional specificity of brain regions from functional Magnetic Resonance Images (fMRI) data is a challenging statistical problem. While the General Linear Model (GLM) remains the standard approach for brain mapping,…

Machine Learning · Computer Science 2012-07-17 Fabian Pedregosa , Alexandre Gramfort , Gaël Varoquaux , Bertrand Thirion , Christophe Pallier , Elodie Cauvet

In this work we propose a novel approach to perform segmentation by leveraging the abstraction capabilities of convolutional neural networks (CNNs). Our method is based on Hough voting, a strategy that allows for fully automatic…

In this study we propose a deformation-based framework to jointly model the influence of aging and Alzheimer's disease (AD) on the brain morphological evolution. Our approach combines a spatio-temporal description of both processes into a…

Neurons and Cognition · Quantitative Biology 2019-05-27 Raphaël Sivera , Hervé Delingette , Marco Lorenzi , Xavier Pennec , Nicholas Ayache

The improved diagnostic accuracy of ultrasound breast examinations remains an important goal. In this study, we propose a biophysical feature based machine learning method for breast cancer detection to improve the performance beyond a…

Image and Video Processing · Electrical Eng. & Systems 2022-07-15 Jihye Baek , Avice M. O'Connell , Kevin J. Parker

The differential diagnosis of neurodegenerative diseases, characterized by overlapping symptoms, may be challenging. Brain imaging coupled with artificial intelligence has been previously proposed for diagnostic support, but most of these…

Image and Video Processing · Electrical Eng. & Systems 2025-02-21 Pierrick Coupé , Boris Mansencal , José V. Manjón , Patrice Péran , Wassilios G. Meissner , Thomas Tourdias , Vincent Planche

MRI-based brain age estimation models aim to assess a subject's biological brain age based on information, such as neuroanatomical features. Various factors, including neurodegenerative diseases, can accelerate brain aging and measuring…

Computer Vision and Pattern Recognition · Computer Science 2025-12-01 Simon Joseph Clément Crête , Marta Kersten-Oertel , Yiming Xiao

Functional networks characterize the coordinated neural activity observed by functional neuroimaging. The prevalence of different networks during resting state periods provide useful features for predicting the trajectory of…

Signal Processing · Electrical Eng. & Systems 2021-11-16 Hassan Baker , Austin J. Brockmeier

Voxel-based lesion-symptom mapping (VLSM) is an important method for basic and translational human neuroscience research. VLSM leverages modern neuroimaging analysis techniques to build on the classic approach of examining the relationship…

Accurate and efficient classification of Alzheimer's disease (AD) severity from brain magnetic resonance imaging (MRI) remains a critical challenge, particularly when limited data and model interpretability are of concern. In this work, we…

Computer Vision and Pattern Recognition · Computer Science 2026-01-06 Faisal Ahmed

Smart systems that can accurately diagnose patients with mental disorders and identify effective treatments based on brain functional imaging data are of great applicability and are gaining much attention. Most previous machine learning…

Computer Vision and Pattern Recognition · Computer Science 2017-12-05 Jumana Dakka , Pouya Bashivan , Mina Gheiratmand , Irina Rish , Shantenu Jha , Russell Greiner

Background and objective Risk prediction models aim at identifying people at higher risk of developing a target disease. Feature selection is particularly important to improve the prediction model performance avoiding overfitting and to…

Machine Learning · Computer Science 2024-02-09 N. Cueto-López , M. T. García-Ordás , V. Dávila-Batista , V. Moreno , N. Aragonés , R. Alaiz-Rodríguez

The prediction and selection of lesion features are two important tasks in voxel-based neuroimage analysis. Existing multivariate learning models take two tasks equivalently and optimize simultaneously. However, in addition to lesion…

Computer Vision and Pattern Recognition · Computer Science 2020-07-20 Xinwei Sun , Wenjing Han , Lingjing Hu , Yuan Yao , Yizhou Wang

Brain age estimation from Magnetic Resonance Images (MRI) derives the difference between a subject's biological brain age and their chronological age. This is a potential biomarker for neurodegeneration, e.g. as part of Alzheimer's disease.…

Computer Vision and Pattern Recognition · Computer Science 2020-10-02 Kyriaki-Margarita Bintsi , Vasileios Baltatzis , Arinbjörn Kolbeinsson , Alexander Hammers , Daniel Rueckert

Functional magnetic resonance imaging (fMRI) is widely used for studying and diagnosing brain disorders, with functional connectivity (FC) matrices providing powerful representations of large-scale neural interactions. However, existing…

Tissues and Organs · Quantitative Biology 2026-04-17 Qianyu Chen , Shujian Yu

Tissue loss in the hippocampi has been heavily correlated with the progression of Alzheimer's Disease (AD). The shape and structure of the hippocampus are important factors in terms of early AD diagnosis and prognosis by clinicians.…

Image and Video Processing · Electrical Eng. & Systems 2022-03-03 Lukas Folle , Sulaiman Vesal , Nishant Ravikumar , Andreas Maier

Alzheimer's disease is a progressive neurodegenerative disorder that gradually deprives the patient of cognitive function and can end in death. With the advancement of technology today, it is possible to detect Alzheimer's disease through…

Image and Video Processing · Electrical Eng. & Systems 2022-07-05 Muhammad Wildan Oktavian , Novanto Yudistira , Achmad Ridok

Recent advances in experimental methods have enabled researchers to collect data on thousands of analytes simultaneously. This has led to correlational studies that associated molecular measurements with diseases such as Alzheimer's, Liver,…

Quantitative Methods · Quantitative Biology 2024-05-20 Divyagna Bavikadi , Ayushi Agarwal , Shashank Ganta , Yunro Chung , Lusheng Song , Ji Qiu , Paulo Shakarian

Alzheimer's disease detection requires expensive neuroimaging or invasive procedures, limiting accessibility. This study explores whether deep learning can enable non-invasive Alzheimer's disease detection through handwriting analysis.…

Image and Video Processing · Electrical Eng. & Systems 2025-08-19 Emanuele Nardone , Tiziana D'Alessandro , Francesco Fontanella , Claudio De Stefano

Histopathological image analysis is a reliable method for prostate cancer identification. In this paper, we present a comparative analysis of two approaches for segmenting glandular structures in prostate images to automate Gleason grading.…

Image and Video Processing · Electrical Eng. & Systems 2025-01-23 Feda Bolus Al Baqain , Omar Sultan Al-Kadi