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The equivalence of two optimality principles leading to Murray's law has been discussed. The first approach is based on minimization of biological work needed for maintaining the blood flow through the vessels at required level. The second…

adap-org · Physics 2007-05-23 I. A. Lubashevsky , V. V. Gafiychuk

The branching behavior of vascular trees is often characterized using Murray's law. We investigate its validity using synthetic vascular trees generated under global optimization criteria. Our synthetic tree model does not incorporate…

Biological Physics · Physics 2024-10-10 Etienne Jessen , Marc C. Steinbach , Charlotte Debbaut , Dominik Schillinger

Murray's cubic branching law ($\alpha=3$) predicts a universal diameter scaling exponent for all hierarchical transport networks, yet arterial trees yield $\alpha \sim 2.7-2.9$. We show that this discrepancy has a structural origin:…

Biological Physics · Physics 2026-05-29 Riccardo Marchesi

Murray's theory of constrained minimum-power branchings is critically reviewed in a generalised framework for a range of cases: channels with arbitrary cross-section shape, laminar flows of Newtonian and non-Newtonian fluids, and low and…

Fluid Dynamics · Physics 2018-12-27 R. Hagmeijer , C. H. Venner

We build an evolutionary scenario that explains how some crucial physiological constraints in the arterial network of mammals - i.e. hematocrit, vessels diameters and arterial pressure drops - could have been selected by evolution. We…

Biological Physics · Physics 2014-05-22 Baptiste Moreau , Benjamin Mauroy

Topology optimization offers optimal material layouts, enabling automation in the design of devices. Given the recent advances in computer technology and additive manufacturing, topology optimization is increasingly being used to design…

Fluid Dynamics · Physics 2021-07-28 T. Phatak , K. B. Nakshatrala

Trees in works of art have stirred emotions in viewers for millennia. Leonardo da Vinci described geometric proportions in trees to provide both guidelines for painting and insights into tree form and function. Da Vinci's Rule of trees…

Physics and Society · Physics 2024-02-22 Jingyi Gao , Mitchell Newberry

We numerically investigate the influence of flow development on secondary flow patterns and subsequent wall shear stress distributions in a curved artery model, and we compute vascular metrics commonly used to assess variations in blood…

Fluid Dynamics · Physics 2022-09-20 Christopher Cox , Michael W. Plesniak

The flow of power law fluids, which include shear thinning and shear thickening as well as Newtonian as a special case, in networks of interconnected elastic tubes is investigated using a residual based pore scale network modeling method…

Fluid Dynamics · Physics 2015-04-27 Taha Sochi

We demonstrate the validity of Murray's law, which represents a scaling relation for branch conductivities in a transportation network, for discrete and continuum models of biological networks. We first consider discrete networks with…

Analysis of PDEs · Mathematics 2019-08-06 Jan Haskovec , Peter Markowich , Giulia Pilli

An analogy between the fractal nature of networks of arteries and that of systems of rivers has been drawn in the previous works. However, the deep structure of the hierarchy of blood vessels has not yet been revealed. This paper is devoted…

Physics and Society · Physics 2018-12-19 Yanguang Chen

Understanding vascular adaptation, namely what drives veins to shrink or grow, is key for the self-organization of flow networks and their optimization. From the top-down principle of minimizing flow dissipation at a fixed metabolic cost…

Soft Condensed Matter · Physics 2023-03-06 Sophie Marbach , Noah Ziethen , Karen Alim

This paper is concerned with the large-time behavior of solutions to the Cauchy problem on the two-fluid Euler-Maxwell system with collisions when initial data are around a constant equilibrium state. The main goal is the rigorous…

Analysis of PDEs · Mathematics 2014-12-02 Renjun Duan , Qingqing Liu , Changjiang Zhu

We study the stationary and transient behaviors of the microemulsion phase subjected to a shear flow. The system is described by a diffusion-convective equation which generalizes the usual Cahn-Hilliard equation. Non-linear terms are…

Soft Condensed Matter · Physics 2009-11-07 Giuseppe Gonnella , Marco Ruggieri

Predicting the flow of non-Newtonian fluids in porous structure is still a challenging issue due to the interplay betwen the microscopic disorder and the non-linear rheology. In this letter, we study the case of an yield stress fluid in a…

Soft Condensed Matter · Physics 2019-06-26 Chen Liu , Andrea De Luca , Alberto Rosso , Laurent Talon

The prevailing theory for metabolic scaling is based on area-preserved, space-filling fractal vascular networks. However, it's known both theoretically and experimentally that animals' vascular systems obey Murray's cubic branching law.…

Quantitative Methods · Quantitative Biology 2022-05-31 Jinkui Zhao

Recent experiments performed on a variety of soft glassy materials have demonstrated that any imposed shear flow serves to simultaneously fluidize these systems in all spatial directions [Ovarlez \textit{et al.} (2010)]. When probed with a…

Soft Condensed Matter · Physics 2012-02-27 T. F. F. Farage , J. M. Brader

It has been shown that geometrical, structural properties vary along the length of the aortic arch. There is a scarcity of studies focus on the variation in the vessel wall thickness of aortic arch. The central premise of this study is that…

Tissues and Organs · Quantitative Biology 2018-06-21 Xiaochang Leng , Xingjian Liu , Will Toress , Tarek Shazly

Despite decades of research on blood flow, an analogue of Navier-Stokes equations that accurately describe blood flow properties has not been established yet. The reason behind this is that the properties of blood flow seem \`a priori non…

As nutrients travel through microcirculation and are absorbed, their availability continuously decreases. However, a uniform nutrient distribution is critical, as it prevents tissue death in poorly supplied areas. How, then, do vascular…

Tissues and Organs · Quantitative Biology 2024-11-18 Georgios Gounaris , Mija Jovchevska , Miguel Ruiz Garcia , Eleni Katifori
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