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Computational pathology foundation models (CPathFMs) have emerged as a powerful approach for analyzing histopathological data, leveraging self-supervised learning to extract robust feature representations from unlabeled whole-slide images.…

Computer Vision and Pattern Recognition · Computer Science 2025-02-27 Dong Li , Guihong Wan , Xintao Wu , Xinyu Wu , Ajit J. Nirmal , Christine G. Lian , Peter K. Sorger , Yevgeniy R. Semenov , Chen Zhao

Asymmetric partition of fate determinants during cell division is a hallmark of cell differentiation. Recent work suggested that such a mechanism is hijacked by cancer cells to increase both their phenotypic heterogeneity and plasticity and…

Developing high-performance and energy-efficient algorithms for maximum matchings is becoming increasingly important in social network analysis, computational sciences, scheduling, and others. In this work, we propose the first maximum…

Distributed, Parallel, and Cluster Computing · Computer Science 2020-10-29 Maciej Besta , Marc Fischer , Tal Ben-Nun , Dimitri Stanojevic , Johannes De Fine Licht , Torsten Hoefler

While generative modeling has achieved remarkable success on tasks like natural language-conditioned image generation, enabling model adaptation from example data points remains a relatively underexplored and challenging problem. To this…

Machine Learning · Computer Science 2026-05-08 Tyler Ingebrand , Ruihan Zhao , Kushagra Gupta , David Fridovich-Keil , Sandeep P. Chinchali , Ufuk Topcu

Computational fluid dynamics (CFD) is increasingly used to study blood flows in patient-specific arteries for understanding certain cardiovascular diseases. The techniques work quite well for relatively simple problems, but need…

Computational Physics · Physics 2018-10-11 Fande Kong , Vitaly Kheyfets , Ender Finol , Xiao-Chuan Cai

This survey explores the transformative impact of foundation models (FMs) in artificial intelligence, focusing on their integration with federated learning (FL) for advancing biomedical research. Foundation models such as ChatGPT, LLaMa,…

Machine Learning · Computer Science 2024-05-14 Xingyu Li , Lu Peng , Yuping Wang , Weihua Zhang

A probabilistic clustering algorithm is proposed for the analysis of forensic DNA mixtures in which individual cells are isolated and short tandem repeats are amplified using the polymerase chain reaction to generate single cell…

Applications · Statistics 2025-10-14 Robert G. Cowell

In the complex landscape of hematologic samples such as peripheral blood or bone marrow, cell classification, delineating diverse populations into a hierarchical structure, presents profound challenges. This study presents LeukoGraph, a…

Machine Learning · Computer Science 2024-03-01 Fatemeh Nassajian Mojarrad , Lorenzo Bini , Thomas Matthes , Stéphane Marchand-Maillet

Functional data, i.e., smooth random functions observed over a continuous domain, are increasingly available in areas such as biomedical research, health informatics, and epidemiology. However, effective statistical analysis for functional…

Machine Learning · Statistics 2026-04-07 Jianbin Tan , Anru R. Zhang

Smart meter data is the foundation for planning and operating the distribution network. Unfortunately, such data are not always available due to privacy regulations. Meanwhile, the collected data may be corrupted due to sensor or…

Machine Learning · Computer Science 2026-02-02 Nan Lin , Yanbo Wang , Jacco Heres , Peter Palensky , Pedro P. Vergara

The advent of modern data processing has led to an increasing tendency towards interdisciplinarity, which frequently involves the importation of different technical approaches. Consequently, there is an urgent need for a unified data…

Machine Learning · Computer Science 2024-06-04 Chen Zhang , Lecheng Jia , Wei Zhang , Ning Wen

Untargeted metabolomic profiling through liquid chromatography-mass spectrometry (LC-MS) measures a vast array of metabolites within biospecimens, advancing drug development, disease diagnosis, and risk prediction. However, the low…

Quantitative Methods · Quantitative Biology 2024-05-27 Marie Breeur , George Stepaniants , Pekka Keski-Rahkonen , Philippe Rigollet , Vivian Viallon

Diffeomorphisms play a crucial role while searching for shapes with fixed topological properties, allowing for smooth deformation of template shapes. Several approaches use diffeomorphism for shape search. However, these approaches employ…

Graphics · Computer Science 2025-07-23 Aalok Gangopadhyay , Dwip Dalal , Progyan Das , Shanmuganathan Raman

Liver cirrhosis is a major global health problem causing millions of deaths annually, and timely detection with aggressive treatment can significantly improve patients' quality of life. Modelling complex diseases from biomedical data is…

Other Quantitative Biology · Quantitative Biology 2026-04-29 Xueyuan Huang , Yuheng Wang , Yuanzhi He , Siqi Gou , Lu Bai , Wenqian Wu , Peifeng Liu , Aijia Wang , Tianhui Fan , Ze Zhou , Jiayu Xu

Conditional flow matching (CFM) stands out as an efficient, simulation-free approach for training flow-based generative models, achieving remarkable performance for data generation. However, CFM is insufficient to ensure accuracy in…

Machine Learning · Computer Science 2026-02-03 Yuhao Huang , Taos Transue , Shih-Hsin Wang , William Feldman , Hong Zhang , Bao Wang

Matching two images while estimating their relative geometry is a key step in many computer vision applications. For decades, a well-established pipeline, consisting of SIFT, RANSAC, and 8-point algorithm, has been used for this task.…

Computer Vision and Pattern Recognition · Computer Science 2019-09-13 Jia-Wang Bian , Yu-Huan Wu , Ji Zhao , Yun Liu , Le Zhang , Ming-Ming Cheng , Ian Reid

The ocean is filled with microscopic microalgae called phytoplankton, which together are responsible for as much photosynthesis as all plants on land combined. Our ability to predict their response to the warming ocean relies on…

Applications · Statistics 2022-08-05 Sangwon Hyun , Mattias Rolf Cape , Francois Ribalet , Jacob Bien

The source distribution in conditional flow matching is a design parameter that can be calibrated to data, not a default isotropic prior. We exploit this in Multi-Fidelity Flow Matching (MFFM), a cascade refinement framework for parametric…

Machine Learning · Computer Science 2026-05-18 Sipeng Chen , Junliang Liu , Hewei Tang , Shibo Li

Calibrating mathematical models of biological processes is essential for achieving predictive accuracy and gaining mechanistic insight. However, this task remains challenging due to limited and noisy data, significant biological…

Quantitative Methods · Quantitative Biology 2025-12-04 Piotr Gwiazda , Alexey Kazarnikov , Anna Marciniak-Czochra , Zuzanna Szymańska

Flexible metadata pipelines are crucial for supporting the FAIR data principles. Despite this need, researchers seldom report their approaches for identifying metadata standards and protocols that support optimal flexibility. This paper…

Computer Vision and Pattern Recognition · Computer Science 2022-11-29 Dom Jebbia , Xiaojun Wang , Yasin Bakis , Henry L. Bart , Jane Greenberg