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In standard clinical within-subject analyses of event-related fMRI data, two steps are usually performed separately: detection of brain activity and estimation of the hemodynamic response. Because these two steps are inherently linked, we…

Applications · Statistics 2012-02-08 Lotfi Chaari , Thomas Vincent , Florence Forbes , Michel Dojat , Philippe Ciuciu

Extracting activation patterns from functional Magnetic Resonance Images (fMRI) datasets remains challenging in rapid-event designs due to the inherent delay of blood oxygen level-dependent (BOLD) signal. The general linear model (GLM)…

Machine Learning · Computer Science 2013-05-14 Fabian Pedregosa , Michael Eickenberg , Bertrand Thirion , Alexandre Gramfort

In this paper we introduce a new hierarchical model for the simultaneous detection of brain activation and estimation of the shape of the hemodynamic response in multi-subject fMRI studies. The proposed approach circumvents a major…

Applications · Statistics 2015-11-13 David Degras , Martin A. Lindquist

Functional magnetic resonance imaging (fMRI) provides an indirect measurement of neuronal activity via hemodynamic responses that vary across brain regions and individuals. Ignoring this hemodynamic variability can bias downstream…

Image and Video Processing · Electrical Eng. & Systems 2026-01-26 William Consagra , Eardi Lila

We present a non-parametric joint estimation method for fMRI task activation values and the hemodynamic response function (HRF). The HRF is modeled as a Gaussian process, making continuous evaluation possible for jittered paradigms and…

Applications · Statistics 2017-09-01 Michael Eickenberg , Aina Frau-Pascual , Andrés Hoyos-Idrobo

Despite the common usage of a canonical, data-independent, hemodynamic response function (HRF), it is known that the shape of the HRF varies across brain regions and subjects. This suggests that a data-driven estimation of this function…

Computational Engineering, Finance, and Science · Computer Science 2014-11-10 Fabian Pedregosa , Michael Eickenberg , Philippe Ciuciu , Bertrand Thirion , Alexandre Gramfort

An essential premise for neuroscience brain network analysis is the successful segmentation of the cerebral cortex into functionally homogeneous regions. Resting-state functional magnetic resonance imaging (rs-fMRI), capturing the…

Neurons and Cognition · Quantitative Biology 2023-09-20 Xiaoxiao Ma , Chunzhi Yi , Zhicai Zhong , Hui Zhou , Baichun Wei , Haiqi Zhu , Feng Jiang

Functional magnetic resonance imaging (fMRI) aims to locate activated regions in human brains when specific tasks are performed. The conventional tool for analyzing fMRI data applies some variant of the linear model, which is restrictive in…

Statistics Theory · Mathematics 2008-08-08 Chunming Zhang , Tao Yu

Purpose: Functional Magnetic Resonance Imaging (fMRI) data acquired through resting-state studies have been used to obtain information about the spontaneous activations inside the brain. One of the approaches for analysis and interpretation…

Image and Video Processing · Electrical Eng. & Systems 2022-02-24 Harshit Parmar , Brian Nutter , Rodney Long , Sameer Antani , Sunanda Mitra

In the event-related functional magnetic resonance imaging (fMRI) data analysis, there is an extensive interest in accurately and robustly estimating the hemodynamic response function (HRF) and its associated statistics (e.g., the magnitude…

Applications · Statistics 2013-12-23 Jiaping Wang , Hongtu Zhu , Jianqing Fan , Kelly Giovanello , Weili Lin

Background: Inference from fMRI data faces the challenge that the hemodynamic system that relates neural activity to the observed BOLD fMRI signal is unknown. New Method: We propose a new Bayesian model for task fMRI data with the following…

Applications · Statistics 2020-06-01 Josef Wilzén , Anders Eklund , Mattias Villani

To characterize atypical brain dynamics under diseases, prevalent studies investigate functional magnetic resonance imaging (fMRI). However, most of the existing analyses compress rich spatial-temporal information as the brain functional…

Image and Video Processing · Electrical Eng. & Systems 2023-05-08 Xiaozhao Liu , Mianxin Liu , Lang Mei , Yuyao Zhang , Feng Shi , Han Zhang , Dinggang Shen

Functional ultrasound (fUS) indirectly measures brain activity by recording changes in cerebral blood volume and flow in response to neural activation. Conventional approaches model such functional neuroimaging data as the convolution…

Signal Processing · Electrical Eng. & Systems 2022-05-26 Aybuke Erol , Chagajeg Soloukey , Bastian Generowicz , Nikki Van Dorp , Sebastiaan Koekkoek , Pieter Kruizinga , Borbala Hunyadi

In the current paper, we introduce a parametric data-driven model for functional near-infrared spectroscopy that decomposes a signal into a series of independent, rescaled, time-shifted, hemodynamic basis functions. Each decomposed waveform…

Signal Processing · Electrical Eng. & Systems 2020-01-24 Marco A. Pinto-Orellana , Diego C. Nascimento , Peyman Mirtaheri , Rune Jonassen , Anis Yazidi , Hugo L. Hammer

Functional magnetic resonance imaging (fMRI) enables indirect detection of brain activity changes via the blood-oxygen-level-dependent (BOLD) signal. Conventional analysis methods mainly rely on the real-valued magnitude of these signals.…

Methodology · Statistics 2023-10-31 Zhengxin Wang , Daniel B. Rowe , Xinyi Li , D. Andrew Brown

Brain parcellations play a ubiquitous role in the analysis of magnetic resonance imaging (MRI) datasets. Over 100 years of research has been conducted in pursuit of an ideal brain parcellation. Different methods have been developed and…

Neurons and Cognition · Quantitative Biology 2021-07-09 Pantea Moghimi , Anh The Dang , Theoden I. Netoff , Kelvin O. Lim , Gowtham Atluri

Accurate brain parcellation in diffusion MRI (dMRI) space is essential for advanced neuroimaging analyses. However, most existing approaches rely on anatomical MRI for segmentation and inter-modality registration, a process that can…

Image and Video Processing · Electrical Eng. & Systems 2025-08-12 Yousef Sadegheih , Dorit Merhof

We propose a method that combines signals from many brain regions observed in functional Magnetic Resonance Imaging (fMRI) to predict the subject's behavior during a scanning session. Such predictions suffer from the huge number of brain…

Computer Vision and Pattern Recognition · Computer Science 2011-04-29 Vincent Michel , Alexandre Gramfort , Gaël Varoquaux , Evelyn Eger , Christine Keribin , Bertrand Thirion

When working with task-related fMRI data, one of the most crucial parts of the data analysis consists of determining a proper estimate of the BOLD response. The following document presents a lite model for the Hemodynamic Response Function…

Neurons and Cognition · Quantitative Biology 2020-04-29 Manuel Morante

Fractals are self-similar and scale-invariant patterns found ubiquitously in nature. A lot of evidences implying fractal properties such as 1/f power spectrums have been also observed in resting state fMRI time series. To explain the…

Applications · Statistics 2012-08-07 Wonsang You , Jörg Stadler
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